Welcome to PMADS: Protein Modification and Drug Sensitivity

PMADS is a freely accessible database that catalogs experimentally supported and computationally inferred associations between protein post-translational modifications (PTMs), drugs, and disease contexts. It enables researchers to explore both how PTMs regulate drug sensitivity and how drugs modulate PTM states in disease-relevant settings.


To ensure clarity and transparency, PMADS organizes its content into two distinct datasets:

Curated Dataset (Reviewed): A high-confidence collection of PTM–drug–disease associations manually extracted from biomedical literature.    👉 Search the curated dataset

Inferred Dataset (Unreviewed): A computationally predicted associations derived from statistical analysis of proteomics data.    👉 Search the inferred dataset

Statistical information

Curated Inferred
Records 4775 43888
PTM types 19 4
PTM sites 1047 22360
Proteins 536 6080
Drugs 1011 39
Diseases 18 1
Diseases (sub) 298 18

Current release: August 10, 2025

Records

PTMs
Disease
Species

Updates

  • 2025-07: Added PRIDE inferred terms.
  • 2025-06: Added non-cancer-related terms.
  • 2025-03: Added cross-references to external DBs.
  • 2025-02: Update PTM site information.
  • 2024-06: Added 3D structure.
  • 2024-04: Initial release of the database.