| Id: | acc0029 |
| Group: | 1sens |
| Protein: | FGFR3 hisone H4 |
| Gene Symbol: | H4C1 |
| Protein Id: | P62805 |
| Protein Name: | H4_HUMAN |
| PTM: | methylation |
| Site: | Arg8 |
| Site Sequence: | --MSGRGKGGKGLGKGGAKRH |
| Disease Category: | Cancer |
| Disease: | Colorectal Cancer |
| Disease Subtype: | |
| Disease Cellline: | SW620 |
| Disease Info: | |
| Drug: | PRMT5 KO |
| Drug Info: | - |
| Effect: | modulate |
| Effect Info: | "Knockdown of AMI-1 or inhibition of PRMT5 leads to the downregulation of FGFR3 and eIF4E, thereby inhibiting colorectal cancer. PRMT5 regulates the methylation of H3R8 and H4R3 on the promoters of FGFR3 and eIF4E." |
| Note: | "histone, Non-conventional drugs" |
| Score: | 3.0 |
| Pubmed(PMID): | 26078354 |
| Sentence Index: | 26078354_0 |
| Sentence: | Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. |
Sequence & Structure:
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| K | 8 | D | Breast cancer | Acetylation | 21146603 |
| K | 8 | D | Friedreich's ataxia | Acetylation | 18045775 |
| K | 8 | D | Fragile X syndrome | Methylation | 18628788 |
| K | 8 | U | Systemic lupus erythematosus | Acetylation | 17530637 ; 25611806 |
| K | 8 | U | Non-small cell lung cancer | Methylation | 18974389 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
