Id: acc0035
Group: 1sens
Protein: eIF4E histone H3
Gene Symbol: H3C1
Protein Id: P68431
Protein Name: H31_HUMAN
PTM: methylation
Site: Arg8
Site Sequence: --MARTKQTARKSTGGKAPRK
Disease Category: Cancer
Disease: Colorectal Cancer
Disease Subtype:
Disease Cellline: HCT116
Disease Info:
Drug: PRMT5 KO
Drug Info: -
Effect: modulate
Effect Info: "Knockdown of AMI-1 or inhibition of PRMT5 leads to the downregulation of FGFR3 and eIF4E, thereby inhibiting colorectal cancer. PRMT5 regulates the methylation of H3R8 and H4R3 on the promoters of FGFR3 and eIF4E."
Note: "histone, Non-conventional drugs"
Score: 3.0
Pubmed(PMID): 26078354
Sentence Index:
Sentence:

Sequence & Structure:

MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
K 27 A Oligodendroglioma Methylation 34020723
K 4 D Breast cancer Methylation 19943104
K 27 D Cervical intraepithelial neoplasia Acetylation 28716899
K 27 D Ovarian cancer Methylation 20053926
K 27 D Malignant peripheral nerve sheath tumor Methylation 28752843
K 27 D Autism spectrum disorder Methylation 23423141
K 4 D Lung cancer Methylation 26301496
K 4 D Liver cancer Methylation 26301496
K 4 D Breast cancer Methylation 26301496
K 27 D Acute myelogenous leukemia Methylation 22897849
K 4 D Fragile X syndrome Methylation 18628788
K 4 D Oral squamous cell carcinoma Methylation 19753335
K 4 D Prostate cancer Methylation 19739128
K 18 D Pancreatic carcinoma Methylation 20142597
K 18 D Hepatocellular carcinoma Acetylation 25613642
K 9 D Prostate cancer Methylation 19739128
K 9 D Pancreatic carcinoma Methylation 20142597
K 4 D Pancreatic carcinoma Methylation 20142597
K 27 D Systemic lupus erythematosus Methylation 36165173
K 9 D Diabetes mellitus Acetylation 23423566
K 9 D Friedreich's ataxia Acetylation 18045775
K 9 D Prostate cancer Acetylation 19885564
K 9 D Systemic lupus erythematosus Acetylation 36165173
S 10 D Breast cancer Phosphorylation 21146603
K 14 D Cervical intraepithelial neoplasia Acetylation 28716899
K 14 D Prostate cancer Acetylation 19885564
K 18 D Prostate cancer Acetylation 19885564
K 14 D Systemic lupus erythematosus Acetylation 36165173
K 23 D Prostate cancer Acetylation 19885564
K 27 U Follicular lymphoma Methylation 35661922
T 11 U Prostate cancer Phosphorylation 18066052
K 4 U Bile duct cancer Methylation 19896696
K 4 U Gastric cancer Methylation 19896696
K 4 U Neuroendocrine cancer Methylation 19896696
K 4 U Pancreatic ductal adenocarcinoma Methylation 19896696
T 6 U Prostate cancer Phosphorylation 20228790
K 9 U Friedreich's ataxia Methylation 18045775
K 4 U Oral squamous cell carcinoma Methylation 19753335
S 10 U Breast adenocarcinoma Phosphorylation 16461563
K 27 U Pediatric-type follicular lymphoma Methylation 35661922
K 27 U Primary cutaneous follicle center cell lymphoma Methylation 35661922
K 79 U Leukemia Methylation 23361907
K 9 U Friedreich's ataxia Methylation 18045775
K 4 U Autism spectrum disorder Methylation 23423141
K 56 U Colorectal cancer Acetylation 19270680
K 9 U Prostate cancer Acetylation 19935671
K 4 U Marfan syndrome Acetylation 20829218
K 9 U Diabetes mellitus Acetylation 23423566
K 9 U Gastric adenocarcinoma Acetylation 18470569
K 9 U Type 2 diabetes Acetylation 34944721
K 14 U Marfan syndrome Acetylation 20829218
K 18 U Colorectal cancer Acetylation 19057998
K 18 U Esophageal carcinoma Acetylation 20142251
K 27 U Anaplastic large cell lymphoma Acetylation 22899583
K 27 U Melanoma Acetylation 32079144
K 27 U Merkel cell carcinoma Acetylation 25941994
K 56 U Astrocytoma Acetylation 19270680
K 4 U Prostate cancer Methylation 19935671
K 56 U Glioma Acetylation 19270680
K 56 U Laryngeal cancer Acetylation 19270680
K 56 U Oligodendroglioma Acetylation 19270680
K 56 U Testicular cancer Acetylation 19270680
K 56 U Thyroid cancer Acetylation 19270680
K 36 U Acute myelogenous leukemia Methylation 17589499
K 4 U Marfan syndrome Methylation 20829218
K 9 U Breast cancer Methylation 19943104
K 27 U Fragile X syndrome Methylation 18628788
K 36 U Clear cell kidney cancer Methylation 28754676
K 79 U Acute lymphocytic leukemia Methylation 18977325
K 79 U Lung cancer Methylation 22190683

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: