Id: | acc0057 |
Group: | 1sens |
Protein: | JNK |
Gene Symbol: | Mapk8 |
Protein Id: | P49185 |
Protein Name: | MK08_RAT |
PTM: | phosphorylation |
Site: | Thr183 |
Site Sequence: | RTAGTSFMMTPYVVTRYYRAP |
Disease Category: | Endocrine and metabolic diseases |
Disease: | Insulinoma |
Disease Subtype: | RINm5F |
Disease Cellline: | RINm5F |
Disease Info: | |
Drug: | hypericin |
Drug Info: | - |
Effect: | modulate |
Effect Info: | Photoactivated hypericin inhibits the proliferation of RINm5F insulinoma cells by downregulating the phosphorylation of JNK and ERK. |
Note: | site unclear |
Score: | 4.0 |
Pubmed(PMID): | 26182357 |
Sentence Index: | 26182357_0 |
Sentence: | Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio. |
Sequence & Structure:
MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
T | 183 | D | Alzheimer's disease | Phosphorylation | 23474850 |
T | 183 | D | Short-term oestrogen deprivation | Phosphorylation | 23474850 |
T | 183 | U | Alzheimer's disease | Phosphorylation | 23474850 |
T | 183 | U | Short-term oestrogen deprivation | Phosphorylation | 23474850 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.