Id: acc0058
Group: 1sens
Protein: JNK
Gene Symbol: Mapk8
Protein Id: P49185
Protein Name: MK08_RAT
PTM: phosphorylation
Site: Tyr185
Site Sequence: AGTSFMMTPYVVTRYYRAPEV
Disease Category: Endocrine and metabolic diseases
Disease: Insulinoma
Disease Subtype: RINm5F
Disease Cellline: RINm5F
Disease Info:
Drug: hypericin
Drug Info: -
Effect: modulate
Effect Info: Photoactivated hypericin inhibits the proliferation of RINm5F insulinoma cells by downregulating the phosphorylation of JNK and ERK.
Note: site unclear
Score: 4.0
Pubmed(PMID): 26182357
Sentence Index:
Sentence:

Sequence & Structure:

MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
Y 185 D Alzheimer's disease Phosphorylation 23474850
Y 185 D Short-term oestrogen deprivation Phosphorylation 23474850
Y 185 U Alzheimer's disease Phosphorylation 23474850
Y 185 U Short-term oestrogen deprivation Phosphorylation 23474850

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: