| Id: | acc0258 |
| Group: | 1sens |
| Protein: | IkappaBalpha |
| Gene Symbol: | Ikbkb |
| Protein Id: | A0A1U7QI43 |
| Protein Name: | A0A1U7QI43_MESAU |
| PTM: | phosphorylation |
| Site: | Ser36 |
| Site Sequence: | GNVIRWHNQATGEQIAIKQCR |
| Disease Category: | Cancer |
| Disease: | Oral Cancer |
| Disease Subtype: | SCC |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Andrographolide |
| Drug Info: | "Andrographolide is a diterpenoid lactone derived from the plant *Andrographis paniculata*, known for its anti-inflammatory, antiviral, and immunomodulatory properties." |
| Effect: | modulate |
| Effect Info: | "Drugs reduce protein phosphorylation, thereby inhibiting tumors." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 21841043 |
| Sentence Index: | 21841043_4 |
| Sentence: | "Compared with 4H-Andro, Andro reduced phosphorylation of p65 (Ser536) and IkappaBalpha (Ser32/36) for inhibiting aberrant NF-kappaB activation, suppressed c-Myc and cyclin D1 expression and attenuated neoplastic cell proliferation, promoted cancerous cell apoptosis, and mitigated tumor-induced angiogenesis." |
Sequence & Structure:
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRDRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHILNMVTGTVHTYPVTEDESLQSLKSRIREDTGILENDQELLQEAGLVLLPDKPATQCISDSKPNEGVTLDMDLVFLFDNSKITYETQITPRPQPESVSCILQEPKRNLSFFQLRKVWGQVWHSIRTLKEDGNRLQQGQRAAMMNLLRNNSCLSKMKNVMASMAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSEKLLLAWKEMEQAVEQCGREDDVKRLVEKMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRERPRDQRTDGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPCSACDSLPDSAKKSGELVAEAHALCTRLESMLQSTVKEQDHSFTTLDWSWLQMEDEERGSLEQACD
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
