Id: acc0350
Group: 1sens
Protein: p27
Gene Symbol: CDKN1B
Protein Id: P46527
Protein Name: CDN1B_HUMAN
PTM: phosphorylation
Site: Thr187
Site Sequence: SPNAGSVEQTPKKPGLRRRQT
Disease Category: Cancer
Disease: Hepatocellular Carcinoma
Disease Subtype:
Disease Cellline: HuH-7
Disease Info:
Drug: MIF4GD OV
Drug Info: -
Effect: modulate
Effect Info: "In hepatocellular carcinoma (HCC) cells, MIF4GD binds to p27 and inhibits the phosphorylation of p27, thereby stabilizing p27. Overexpression of MIF4GD leads to an increase in p27 levels and a reduction in cell proliferation."
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 24336329
Sentence Index:
Sentence:

Sequence & Structure:

MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
CDKN1B-Thr187
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 187 P Breast cancer/tumor/carcinoma Phosphorylation 23769441
T 187 U Lymphoma Phosphorylation 22492278
T 187 U B-cell lymphoma Phosphorylation 21338280
T 187 U Hepatocellular carcinoma Phosphorylation 33574916
T 187 U Prostate cancer/carcinoma/adenocarcinoma Phosphorylation 23707764
T 187 U T-cell acute lymphoblastic leukemia Phosphorylation 34407842

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: