| Id: | acc0387 |
| Group: | 1sens |
| Protein: | VASP |
| Gene Symbol: | Vasp |
| Protein Id: | P70460 |
| Protein Name: | VASP_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser157 |
| Site Sequence: | MERRVSNAGGPPAPPAGGPPP |
| Disease Category: | Cancer |
| Disease: | Colorectal Cancer |
| Disease Subtype: | |
| Disease Cellline: | CT26 |
| Disease Info: | |
| Drug: | Baicalein |
| Drug Info: | - |
| Effect: | modulate |
| Effect Info: | The drug inhibits tumor metastasis and enhances protein phosphorylation. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 25268843 |
| Sentence Index: | 25268843_0 |
| Sentence: | Baicalein inhibits agonist- and tumor cell-induced platelet aggregation while suppressing pulmonary tumor metastasis via cAMP-mediated VASP phosphorylation along with impaired MAPKs and PI3K-Akt activation. |
Sequence & Structure:
MSETVICSSRATVMLYDDSNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIIRGVKYNQATPIFHQWRDARQVWGLNFGSKEDAIQFATGMANALEALEGGGPPPAPAPPAWSAQNGPSPEELEQQKRQPEHMERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPSSGVSGAGHGAGAAPPPAPPLPTAQGPNSGGSGAPGLAAAIAGAKLRKVSKQEEASGGPLAPKAENSRSTGGGLMEEMNAMLARRRKATQVGEKPPKDESASEESEARLPAQSEPVRRPWEKNSTTLPRMKSSSSVTTSEAHPSTPCSSDDSDLERVKQELLEEVRKELQKMKEEIIEVFVQELRKRGSP
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 239 | U | Marfan syndrome | Phosphorylation | 33976159 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
