Id: acc0445
Group: 1sens
Protein: AMPK
Gene Symbol: PRKAB1
Protein Id: Q9Y478
Protein Name: AAKB1_HUMAN
PTM: phosphorylation
Site: Thr180
Site Sequence: QKCSDVSELSSSPPGPYHQEP
Disease Category: Cancer
Disease: Colorectal Cancer
Disease Subtype:
Disease Cellline: HT29
Disease Info:
Drug: TPA
Drug Info: -
Effect: modulate
Effect Info: "After TPA treatment, the expression of MMP-7 in low-invasive cells increased, and the phosphorylation of AMPK decreased."
Note:
Score: 4.0
Pubmed(PMID): 26116564
Sentence Index:
Sentence:

Sequence & Structure:

MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
PRKAB1 ACADESINE AMP-activated protein kinase, AMPK activator 3 - cardiovascular disease ATC
PRKAB1 ACADESINE AMP-activated protein kinase, AMPK activator 1 Completed chronic lymphocytic leukemia ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

PRKAB1-Ser101
Cancer Intensity
BRCA
COAD 0.707
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC -0.707
PDAC
UCEC
PRKAB1-Ser108
Cancer Intensity
BRCA -1.494
COAD -0.808
HGSC 2.404
ccRCC -0.429
GBM 0.568
HNSC 0.662
LUAD -0.23
LUSC -0.269
non_ccRCC -0.464
PDAC -0.124
UCEC 0.184
PRKAB1-Ser181
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
PRKAB1-Ser182
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
PRKAB1-Ser24
Cancer Intensity
BRCA
COAD -0.484
HGSC 1.485
ccRCC
GBM
HNSC
LUAD -0.33
LUSC
non_ccRCC
PDAC
UCEC -0.672
PRKAB1-Ser40
Cancer Intensity
BRCA 0.814
COAD
HGSC
ccRCC -0.613
GBM -1.812
HNSC 1.42
LUAD 0.127
LUSC 0.046
non_ccRCC -0.974
PDAC 0.177
UCEC 0.815
PRKAB1-Ser49
Cancer Intensity
BRCA 2.169
COAD
HGSC
ccRCC -0.183
GBM -0.211
HNSC 0.744
LUAD -0.979
LUSC -0.771
non_ccRCC 0.02
PDAC -1.027
UCEC 0.238
PRKAB1-Ser94
Cancer Intensity
BRCA
COAD
HGSC
ccRCC 0.707
GBM
HNSC -0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC
PRKAB1-Ser96
Cancer Intensity
BRCA 0.532
COAD 0.368
HGSC -2.188
ccRCC 0.625
GBM
HNSC -1.177
LUAD 0.495
LUSC 0.195
non_ccRCC
PDAC 0.382
UCEC 0.769
PRKAB1-Tyr187
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: