Id: acc0481
Group: 1sens
Protein: CCND1
Gene Symbol: CCND1
Protein Id: P24385
Protein Name: CCND1_HUMAN
PTM: phosphorylation
Site: Thr286
Site Sequence: EEEEVDLACTPTDVRDVDI--
Disease Category: Cancer
Disease: Colorectal Cancer
Disease Subtype:
Disease Cellline: SW480
Disease Info:
Drug: kahweol
Drug Info: "Kahweol is a coffee-specific diterpene found in coffee beans, exhibiting anti-inflammatory and hepatoprotective effects. "
Effect: modulate
Effect Info: "Kahweol rapidly phosphorylates cyclin D1 at the Thr286 site, thereby inducing the proteasomal degradation of cyclin D1."
Note:
Score: 4.0
Pubmed(PMID): 27424123
Sentence Index:
Sentence:

Sequence & Structure:

MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
CCND1 BRICICLIB G1/S-specific cyclin D1 inhibitor 1 Terminated acute lymphoblastic leukemia ClinicalTrials
CCND1 BRICICLIB G1/S-specific cyclin D1 inhibitor 1 Terminated lymphoma ClinicalTrials
CCND1 BRICICLIB G1/S-specific cyclin D1 inhibitor 1 Terminated neoplasm ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
CCND1-Thr286
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 286 D Breast cancer Phosphorylation 32944401
T 286 U Breast cancer Phosphorylation 36797347

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: