Id: acc0525
Group: 1sens
Protein: GFAT1
Gene Symbol: GFPT1
Protein Id: Q06210
Protein Name: GFPT1_HUMAN
PTM: phosphorylation
Site: Ser243
Site Sequence: GSKFTRWGSQGERGKDKKGSC
Disease Category: Cancer
Disease: Pancreas Cancer
Disease Subtype:
Disease Cellline: MIA PaCa-2
Disease Info:
Drug: 2-Deoxy-d-glucose
Drug Info: "2-Deoxy-D-glucose (2-DG) is a glucose analog that inhibits glycolysis by interfering with glucose metabolism, and it has been investigated for its potential in cancer therapy, viral infections, and metabolic diseases due to its ability to disrupt energy production in rapidly proliferating cells."
Effect: modulate
Effect Info: "2-Deoxy-d-glucose increases the phosphorylation of GFAT1 and AMPK, leading to endoplasmic reticulum-related apoptosis."
Note:
Score: 4.0
Pubmed(PMID): 29753740
Sentence Index:
Sentence:

Sequence & Structure:

MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRWGSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

GFPT1-Ser103
Cancer Intensity
BRCA 1.143
COAD
HGSC
ccRCC
GBM
HNSC -1.521
LUAD -0.687
LUSC 0.634
non_ccRCC
PDAC 0.671
UCEC -0.24
GFPT1-Ser205
Cancer Intensity
BRCA 0.083
COAD -0.261
HGSC 2.009
ccRCC
GBM
HNSC 0.106
LUAD -0.771
LUSC 0.552
non_ccRCC -1.669
PDAC 0.287
UCEC -0.335
GFPT1-Ser253
Cancer Intensity
BRCA -0.828
COAD -1.535
HGSC
ccRCC -0.048
GBM
HNSC -0.162
LUAD -0.463
LUSC 0.078
non_ccRCC 1.359
PDAC 1.69
UCEC -0.091
GFPT1-Ser257
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
GFPT1-Ser261
Cancer Intensity
BRCA -0.899
COAD 0.92
HGSC 0.98
ccRCC -1.551
GBM
HNSC 0.432
LUAD -0.633
LUSC 0
non_ccRCC
PDAC -0.652
UCEC 1.403
GFPT1-Thr262
Cancer Intensity
BRCA
COAD 0.819
HGSC 0.296
ccRCC -1.114
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
GFPT1-Thr263
Cancer Intensity
BRCA -1.334
COAD 0.998
HGSC 0.458
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC -0.121
PDAC
UCEC

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: