| Id: | acc0538 |
| Group: | 1sens |
| Protein: | SMAD3 |
| Gene Symbol: | Smad3 |
| Protein Id: | P84025 |
| Protein Name: | SMAD3_RAT |
| PTM: | phosphorylation |
| Site: | Ser425 |
| Site Sequence: | SPSIRCSSVS----------- |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Pituitary Tumor |
| Disease Subtype: | |
| Disease Cellline: | GH3 |
| Disease Info: | |
| Drug: | trastuzumab + TGFB1 |
| Drug Info: | "Trastuzumab is a recombinant humanized monoclonal antibody targeting HER2 (human epidermal growth factor receptor 2), used for the treatment of HER2-positive breast cancer and gastric cancer. TGFB1: - " |
| Effect: | modulate |
| Effect Info: | "Incubation of trastuzumab with TGFB1 induces a significant increase in the expression of p-Smad2/3 and a significant decrease in the phosphorylation of ERK1/2, thereby inhibiting tumor proliferation." |
| Note: | drug comb |
| Score: | 4.0 |
| Pubmed(PMID): | 29875136 |
| Sentence Index: | 29875136_6 |
| Sentence: | "In tumoral GH3 cells, co-incubation with trastuzumab and TGFB1 significantly decreased cell proliferation, an effect accompanied by a reduction in ERK1/2 phosphorylation, an increase of SMAD2/3 activation." |
Sequence & Structure:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
