| Id: | acc0551 |
| Group: | 1sens |
| Protein: | UVRAG |
| Gene Symbol: | UVRAG |
| Protein Id: | Q9P2Y5 |
| Protein Name: | UVRAG_HUMAN |
| PTM: | ubiquitination |
| Site: | Lys517 |
| Site Sequence: | SSENERLQYKTPPPSYNSALA |
| Disease Category: | Cancer |
| Disease: | Hepatocellular Carcinoma |
| Disease Subtype: | |
| Disease Cellline: | HuH-7 |
| Disease Info: | |
| Drug: | D4476 |
| Drug Info: | "D4476 is a potent, selective, and cell-permeable casein kinase 1 (CK1) inhibitor with an IC50 value of 0.3 μM in vitro." |
| Effect: | modulate |
| Effect Info: | "SMURF1-mediated ubiquitination of UVRAG at lysine residues 517 and 559 or the D4476 compound, which blocks phosphorylation at Ser522, enhances the lysosomal degradation of EGFR, thereby significantly inhibiting HCC." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 30686098 |
| Sentence Index: | 30686098_8 |
| Sentence: | "Importantly, we provide in vitro and in vivo evidence that UVRAG ubiquitination at lysine residues 517 and 559 or prevention of Ser522 phosphorylation by D4476, a CSNK1A1 inhibitor, enhances the lysosomal degradation of EGFR, which significantly inhibits hepatocellular carcinoma (HCC) growth." |
Sequence & Structure:
MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHKQQIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETERKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQAEEIIGLEATGFASGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSSFRRPRRSSDK
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
