| Id: | acc0595 |
| Group: | 1sens |
| Protein: | TBK1 |
| Gene Symbol: | Tbk1 |
| Protein Id: | Q9WUN2 |
| Protein Name: | TBK1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser172 |
| Site Sequence: | ELEDDEQFVSLYGTEEYLHPD |
| Disease Category: | Cancer |
| Disease: | Colorectal Cancer |
| Disease Subtype: | Colon Cancer |
| Disease Cellline: | MC38 |
| Disease Info: | |
| Drug: | ionizing radiation |
| Drug Info: | - |
| Effect: | increase |
| Effect Info: | "Vancomycin reduces the level of butyric acid by decreasing butyric acid-producing bacteria, relieves its inhibition on the phosphorylation of TBK1 and IRF3, thereby enhancing the expression of type I interferon (IFN-I) mediated by the STING pathway, promoting the anti-tumor immune response of CD8+ T cells, and improving the efficacy of ionizing radiation (IR) therapy." |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 33496784 |
| Sentence Index: | 33496784_6 |
| Sentence: | "Local butyrate inhibited STING-activated type I IFN expression in dendritic cells (DCs) through blockade of TBK1 and IRF3 phosphorylation, which abrogated IR-induced tumor-specific cytotoxic T cell immune responses without directly protecting tumor cells from radiation." |
Sequence & Structure:
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLVLELGRLAQHFPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDGDASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVELVKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSHFSEECVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQKMLAASGGVKHAMAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
