Id: acc0671
Group: 1sens
Protein: DRP1
Gene Symbol: DNM1L
Protein Id: O00429
Protein Name: DNM1L_HUMAN
PTM: phosphorylation
Site: Ser616
Site Sequence: SKPIPIMPASPQKGHAVNLLD
Disease Category: Cancer
Disease: Oral Cancer
Disease Subtype: SCC
Disease Cellline: CAL27
Disease Info:
Drug: alantolactone
Drug Info: "Alantolactone is a sesquiterpene lactone derived from the roots of *Inula helenium* (elecampane), traditionally used in herbal medicine for its anti-inflammatory and antimicrobial properties."
Effect: modulate
Effect Info: "Adamantanone lactone downregulates the phosphorylation of Drp1, thereby inhibiting the proliferation and promoting the apoptosis of OSCC."
Note:
Score: 4.0
Pubmed(PMID): 37198593
Sentence Index:
Sentence:

Sequence & Structure:

MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
DNM1L-Ser616
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 616 P Huntington's disease Phosphorylation 29397067
S 616 U Alzheimer's disease Phosphorylation 37174687
S 616 U Kidney cancer Phosphorylation 35927303
S 616 U Nasopharyngeal carcinoma Phosphorylation 32433544
S 616 U Parkinson's disease Phosphorylation 31308800
S 616 U Pulmonary hypertension Phosphorylation 37442283
S 616 U Heart failure Phosphorylation 27739424
S 616 U Pancreatic cancer Phosphorylation 25658205
S 616 U Oral cancer Phosphorylation 36779631

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: