| Id: | acc0699 |
| Group: | 1sens |
| Protein: | IGF2BP3 |
| Gene Symbol: | IGF2BP3 |
| Protein Id: | O00425 |
| Protein Name: | IF2B3_HUMAN |
| PTM: | ubiquitination |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cancer |
| Disease: | Colorectal Cancer |
| Disease Subtype: | |
| Disease Cellline: | HCT116 |
| Disease Info: | |
| Drug: | Berberine |
| Drug Info: | "Berberine is a bioactive alkaloid derived from plants such as *Berberis vulgaris*, with demonstrated hypoglycemic, lipid-lowering, and antimicrobial effects, primarily mediated through AMP-activated protein kinase (AMPK) activation and gut microbiota modulation." |
| Effect: | modulate |
| Effect Info: | "Berberine promotes the ubiquitination of IGF2BP3 through TRIM21, thereby inducing G1/S phase arrest in colorectal cancer cells." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 36822301 |
| Sentence Index: | 36822301_0 |
| Sentence: | Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells. |
Sequence & Structure:
MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
