| Id: | acc0728 |
| Group: | 2sens |
| Protein: | CCAR2 |
| Gene Symbol: | CCAR2 |
| Protein Id: | Q8N163 |
| Protein Name: | CCAR2_HUMAN |
| PTM: | acetylation |
| Site: | Lys |
| Site Sequence: | |
| Disease Category: | Cancer |
| Disease: | Colorectal Cancer |
| Disease Subtype: | |
| Disease Cellline: | HCT116 |
| Disease Info: | |
| Drug: | sulforaphane |
| Drug Info: | "Sulforaphane is an isothiocyanate compound derived from cruciferous vegetables like broccoli, recognized for its antioxidant and chemopreventive properties, including potential anti-cancer activity through modulation of detoxification enzymes and cellular signaling pathways." |
| Effect: | modulate |
| Effect Info: | "SFN induces novel N-terminal acetylation of CCAR2, reduces its interaction with histone deacetylase 3 and beta-catenin, interferes with the Wnt co-activator function of CCAR2, and thus inhibits tumors." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 30643017 |
| Sentence Index: | 30643017_3-4 |
| Sentence: | "Here we identify cell cycle and apoptosis regulator 2 (CCAR2) as an early target for acetylation in colon cancer cells treated with sulforaphane. N-terminal acetylation of CCAR2 diminished its interactions with histone deacetylase 3 and beta-catenin, interfering with Wnt coactivator functions of CCAR2, including in cells harboring genetically encoded CCAR2 acetylation." |
Sequence & Structure:
MSQFKRQRINPLPGGRNFSGTASTSLLGPPPGLLTPPVATELSQNARHLQGGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFPQKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPRHDLPPYRVHLTPYTVDSPICDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLSQPFSLHHPSRIQVSSEKEAAPDAGAEPITADSDPAYSSKVLLLSSPGLEELYRCCMLFVDDMAEPRETPEHPLKQIKFLLGRKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQTGIDLSGCTKWWRFAEFQYLQPGPPRRLQTVVVYLPDVWTIMPTLEEWEALCQQKAAEAAPPTQEAQGETEPTEQAPDALEQAADTSRRNAETPEATTQQETDTDLPEAPPPPLEPAVIARPGCVNLSLHGIVEDRRPKERISFEVMVLAELFLEMLQRDFGYRVYKMLLSLPEKVVSPPEPEKEEAAKEEATKEEEAIKEEVVKEPKDEAQNEGPATESEAPLKEDGLLPKPLSSGGEEEEKPRGEASEDLCEMALDPELLLLRDDGEEEFAGAKLEDSEVRSVASNQSEMEFSSLQDMPKELDPSAVLPLDCLLAFVFFDANWCGYLHRRDLERILLTLGIRLSAEQAKQLVSRVVTQNICQYRSLQYSRQEGLDGGLPEEVLFGNLDLLPPPGKSTKPGAAPTEHKALVSHNGSLINVGSLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTLAAEMQELRVRLAEAEETARTAERQKSQLQRLLQELRRRLTPLQLEIQRVVEKADSWVEKEEPAPSN
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| CCAR2-Lys215 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.148 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.685 |
| LUSC | 0.462 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CCAR2-Lys216 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.821 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 1.114 |
| LUSC | -0.292 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CCAR2-Lys344 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.901 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | 1.076 |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.176 |
| CCAR2-Lys54 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.405 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.734 |
| HNSC | |
| LUAD | |
| LUSC | 1.139 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CCAR2-Lys790 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| CCAR2-Lys908 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.413 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.486 |
| LUSC | 1.102 |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.174 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
