Id: | acc0744 |
Group: | 2sens |
Protein: | AR |
Gene Symbol: | AR |
Protein Id: | P10275 |
Protein Name: | ANDR_HUMAN |
PTM: | phosphorylation |
Site: | Tyr267 |
Site Sequence: | SPGEQLRGDCMYAPLLGVPPA |
Disease Category: | Cancer |
Disease: | Prostate Cancer |
Disease Subtype: | castration-resistant prostate cancer |
Disease Cellline: | C4-2B |
Disease Info: | |
Drug: | (R)-9b |
Drug Info: | "(R)-9b is a small-molecule inhibitor targeting the tyrosine kinase ACK1 (also known as TNK2), which regulates androgen receptor expression, and has demonstrated efficacy in suppressing the proliferation of prostate, breast, and lung cancer cells in preclinical studies. " |
Effect: | modulate |
Effect Info: | "Oral administration and subcutaneous injection of the ACK1 small molecule inhibitor (R)-9b can not only inhibit the phosphorylation of AR at Y267 and the subsequent acetylation at K609, but also suppress the growth of enzalutamide-resistant CRPC xenograft tumors in mice." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 35704598 |
Sentence Index: | 35704598_7-8 |
Sentence: | "ACK1 kinase-mediated AR Y267 phosphorylation was a prerequisite for AR K609 acetylation, which spawned positive feedback loops at both the transcriptional and posttranslational level that regenerated and sustained high AR and ACK1 expression. Consistent with these findings, oral and subcutaneous treatment with ACK1 small-molecule inhibitor, (R)-9b, not only curbed AR Y267 phosphorylation and subsequent K609 acetylation but also compromised enzalutamide-resistant CRPC xenograft tumor growth in mice." |
Sequence & Structure:
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
Select PDB:
Target | Drug name | MOA | Phase | Status | Disease | Source |
---|---|---|---|---|---|---|
AR | ENZALUTAMIDE | Androgen Receptor antagonist | 4 | Unknown status | metastatic prostate cancer | ClinicalTrials |
AR | FLUTAMIDE | Androgen Receptor antagonist | 4 | - | carcinoma | DailyMed |
AR | BICALUTAMIDE | Androgen Receptor antagonist | 4 | - | carcinoma | DailyMed |
AR | ENZALUTAMIDE | Androgen Receptor antagonist | 4 | - | neoplasm | ATC |
AR | TESTOSTERONE ENANTHATE | Androgen Receptor agonist | 4 | - | neoplasm | DailyMed DailyMed |
AR | TESTOSTERONE CYPIONATE | Androgen Receptor agonist | 4 | - | neoplasm | DailyMed |
AR | TESTOSTERONE UNDECANOATE | Androgen Receptor agonist | 4 | - | neoplasm | DailyMed DailyMed |
AR | NILUTAMIDE | Androgen Receptor antagonist | 4 | - | neoplasm | ATC |
AR | FLUOXYMESTERONE | Androgen Receptor agonist | 4 | - | neoplasm | DailyMed |
AR | DAROLUTAMIDE | Androgen Receptor antagonist | 4 | - | neoplasm | ATC |
AR | BICALUTAMIDE | Androgen Receptor antagonist | 4 | - | neoplasm | ATC |
AR | ABIRATERONE | Androgen Receptor antagonist | 4 | - | neoplasm | ATC |
AR | APALUTAMIDE | Androgen Receptor antagonist | 4 | - | neoplasm | ATC |
AR | TESTOSTERONE | Androgen Receptor agonist | 4 | - | neoplasm | DailyMed DailyMed DailyMed |
AR | ENZALUTAMIDE | Androgen Receptor antagonist | 4 | Completed | prostate adenocarcinoma | ClinicalTrials |
AR | FLUTAMIDE | Androgen Receptor antagonist | 4 | - | neoplasm | ATC |
AR | FLUTAMIDE | Androgen Receptor antagonist | 4 | Recruiting | prostate adenocarcinoma | ClinicalTrials |
AR | APALUTAMIDE | Androgen Receptor antagonist | 4 | Active, not recruiting | prostate adenocarcinoma | ClinicalTrials |
AR | DANAZOL | Androgen Receptor agonist | 4 | - | endometriosis | DailyMed DailyMed |
AR | FLUTAMIDE | Androgen Receptor antagonist | 4 | - | prostate carcinoma | DailyMed DailyMed |
AR | ENZALUTAMIDE | Androgen Receptor antagonist | 4 | - | prostate carcinoma | DailyMed |
AR | APALUTAMIDE | Androgen Receptor antagonist | 4 | - | prostate carcinoma | FDA |
AR | DANAZOL | Androgen Receptor agonist | 4 | - | breast fibrocystic disease | DailyMed |
AR | CLASCOTERONE | Androgen Receptor antagonist | 4 | - | acne | ATC |
AR | CLASCOTERONE | Androgen Receptor antagonist | 4 | Active, not recruiting | acne | ClinicalTrials ClinicalTrials |
Note: Only show clinically investigational or approved drugs with protein targets.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
AARS-Ser249 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.741 |
GBM | -0.982 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | 0.85 |
PDAC | |
UCEC | 0.873 |
AARS-Ser399 | |
---|---|
Cancer | Intensity |
BRCA | 0.047 |
COAD | 0.159 |
HGSC | 2.547 |
ccRCC | -0.52 |
GBM | -0.373 |
HNSC | -0.391 |
LUAD | 0.374 |
LUSC | 0.041 |
non_ccRCC | -0.999 |
PDAC | -0.885 |
UCEC |
AARS-Ser555 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -0.707 |
HGSC | 0.707 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
AARSD1-Ser174 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | -0.707 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.707 |
ADAR-Ser1110 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | 0.707 |
non_ccRCC | |
PDAC | |
UCEC | -0.707 |
ADAR-Ser316 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.887 |
HGSC | |
ccRCC | 0.197 |
GBM | |
HNSC | -1.084 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ADAR-Ser319 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.563 |
HGSC | |
ccRCC | 1.271 |
GBM | -0.317 |
HNSC | -1.707 |
LUAD | |
LUSC | |
non_ccRCC | 0.229 |
PDAC | -0.04 |
UCEC |
ADAR-Ser334 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.574 |
HGSC | |
ccRCC | -0.869 |
GBM | -0.079 |
HNSC | 1.703 |
LUAD | |
LUSC | |
non_ccRCC | -0.913 |
PDAC | -0.416 |
UCEC |
ADAR-Ser35 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.707 |
ADAR-Ser519 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.799 |
GBM | 0.064 |
HNSC | 1.565 |
LUAD | |
LUSC | |
non_ccRCC | 0.116 |
PDAC | -0.946 |
UCEC |
ADAR-Ser528 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 0.707 |
GBM | |
HNSC | -0.707 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ADAR-Ser530 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -0.958 |
HGSC | |
ccRCC | 1.629 |
GBM | 0.131 |
HNSC | -1.094 |
LUAD | |
LUSC | |
non_ccRCC | -0.147 |
PDAC | 0.438 |
UCEC |
ADAR-Ser605 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | 0.707 |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ADAR-Ser611 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.707 |
ADAR-Ser614 | |
---|---|
Cancer | Intensity |
BRCA | -0.924 |
COAD | |
HGSC | 1.53 |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.38 |
LUSC | -0.677 |
non_ccRCC | |
PDAC | |
UCEC | 0.451 |
ADAR-Ser629 | |
---|---|
Cancer | Intensity |
BRCA | -0.492 |
COAD | |
HGSC | 1.776 |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.586 |
LUSC | -0.252 |
non_ccRCC | |
PDAC | |
UCEC | -0.446 |
ADAR-Ser814 | |
---|---|
Cancer | Intensity |
BRCA | 0.311 |
COAD | |
HGSC | 1.499 |
ccRCC | |
GBM | |
HNSC | |
LUAD | -1.152 |
LUSC | -0.091 |
non_ccRCC | |
PDAC | |
UCEC | -0.567 |
ADAR-Ser815 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 0.964 |
GBM | 0.57 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | -1.301 |
PDAC | -0.233 |
UCEC |
ADAR-Ser825 | |
---|---|
Cancer | Intensity |
BRCA | -1.184 |
COAD | |
HGSC | 1.531 |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.145 |
LUSC | -0.426 |
non_ccRCC | |
PDAC | |
UCEC | 0.224 |
ADAR-Thr191 | |
---|---|
Cancer | Intensity |
BRCA | -1.152 |
COAD | |
HGSC | 0.509 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.643 |
ADAR-Thr306 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -1.153 |
HGSC | |
ccRCC | |
GBM | |
HNSC | 0.636 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | 0.516 |
UCEC |
ADAR-Thr308 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -0.04 |
HGSC | |
ccRCC | |
GBM | -0.98 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | 1.019 |
UCEC |
ADAR-Thr322 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -1.119 |
HGSC | |
ccRCC | 0.807 |
GBM | |
HNSC | 0.312 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ADAR-Thr516 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.215 |
HGSC | |
ccRCC | -1.09 |
GBM | |
HNSC | 0.875 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ADAR-Thr601 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | 0.707 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -0.707 |
ADAR-Thr603 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | -0.83 |
ccRCC | |
GBM | |
HNSC | |
LUAD | 1.11 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -0.281 |
ADAR-Thr617 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | 0.707 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -0.707 |
ADAR-Thr808 | |
---|---|
Cancer | Intensity |
BRCA | 0.409 |
COAD | |
HGSC | -1.648 |
ccRCC | |
GBM | |
HNSC | |
LUAD | 1.037 |
LUSC | 0.002 |
non_ccRCC | |
PDAC | |
UCEC | 0.201 |
ADAR-Thr811 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | 1.129 |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.774 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -0.355 |
ADARB1-Ser26 | |
---|---|
Cancer | Intensity |
BRCA | 0.758 |
COAD | |
HGSC | |
ccRCC | 0.249 |
GBM | |
HNSC | -1.731 |
LUAD | 1.131 |
LUSC | -0.166 |
non_ccRCC | |
PDAC | -0.242 |
UCEC |
AP1AR-Ser153 | |
---|---|
Cancer | Intensity |
BRCA | -1.56 |
COAD | -0.18 |
HGSC | |
ccRCC | |
GBM | 0.026 |
HNSC | 1.734 |
LUAD | 0.78 |
LUSC | 0.087 |
non_ccRCC | 0.752 |
PDAC | -0.783 |
UCEC | -0.856 |
AP1AR-Ser193 | |
---|---|
Cancer | Intensity |
BRCA | -0.446 |
COAD | 0.814 |
HGSC | |
ccRCC | -1.016 |
GBM | |
HNSC | |
LUAD | 1.297 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -0.65 |
AP1AR-Thr151 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.832 |
HGSC | |
ccRCC | -0.908 |
GBM | -1.18 |
HNSC | -0.602 |
LUAD | 0.874 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.984 |
AP1AR-Thr195 | |
---|---|
Cancer | Intensity |
BRCA | -1.46 |
COAD | 0.595 |
HGSC | |
ccRCC | -0.203 |
GBM | |
HNSC | -1.059 |
LUAD | 0.8 |
LUSC | 1.445 |
non_ccRCC | |
PDAC | 0.497 |
UCEC | -0.614 |
AR-Ser516 | |
---|---|
Cancer | Intensity |
BRCA | 1.057 |
COAD | |
HGSC | -0.931 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -0.125 |
AR-Ser96 | |
---|---|
Cancer | Intensity |
BRCA | -0.231 |
COAD | 0.453 |
HGSC | 2.44 |
ccRCC | -0.211 |
GBM | 0.341 |
HNSC | |
LUAD | -0.467 |
LUSC | -0.214 |
non_ccRCC | -1.286 |
PDAC | 0.018 |
UCEC | -0.842 |
AR-Thr861 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.707 |
GBM | |
HNSC | |
LUAD | 0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
AR-Tyr858 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.707 |
GBM | |
HNSC | |
LUAD | 0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAF-Ser157 | |
---|---|
Cancer | Intensity |
BRCA | -0.198 |
COAD | -0.131 |
HGSC | 2.957 |
ccRCC | -0.508 |
GBM | -0.144 |
HNSC | -0.195 |
LUAD | -0.366 |
LUSC | -0.445 |
non_ccRCC | 0.022 |
PDAC | -0.323 |
UCEC | -0.669 |
ARAF-Ser162 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.395 |
HGSC | 0.742 |
ccRCC | |
GBM | -1.137 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAF-Ser165 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -0.707 |
HGSC | 0.707 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAF-Ser172 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.232 |
GBM | 0.47 |
HNSC | -0.478 |
LUAD | -1.197 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 1.437 |
ARAF-Ser186 | |
---|---|
Cancer | Intensity |
BRCA | 0.61 |
COAD | -0.34 |
HGSC | 2.004 |
ccRCC | -0.916 |
GBM | 1.069 |
HNSC | -0.511 |
LUAD | -0.695 |
LUSC | 0.172 |
non_ccRCC | -1.639 |
PDAC | 0.021 |
UCEC | 0.226 |
ARAF-Ser212 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -1.223 |
GBM | 0.978 |
HNSC | 0.949 |
LUAD | -0.799 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.094 |
ARAF-Ser214 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.878 |
GBM | 1.004 |
HNSC | 0.973 |
LUAD | -1.128 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.029 |
ARAF-Ser222 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.528 |
GBM | 0.518 |
HNSC | -1.192 |
LUAD | -0.208 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 1.41 |
ARAF-Ser250 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.204 |
GBM | |
HNSC | |
LUAD | -0.882 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 1.086 |
ARAF-Ser257 | |
---|---|
Cancer | Intensity |
BRCA | -1.598 |
COAD | 0.549 |
HGSC | 1.327 |
ccRCC | -1.03 |
GBM | 1.33 |
HNSC | 0.553 |
LUAD | -0.577 |
LUSC | 0.174 |
non_ccRCC | -1.177 |
PDAC | -0.222 |
UCEC | 0.671 |
ARAF-Ser259 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -0.98 |
HGSC | 1.368 |
ccRCC | 0.731 |
GBM | |
HNSC | -0.623 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -0.495 |
ARAF-Ser264 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -0.707 |
HGSC | 0.707 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAF-Ser269 | |
---|---|
Cancer | Intensity |
BRCA | 0.519 |
COAD | |
HGSC | 0.874 |
ccRCC | -1.087 |
GBM | -1.442 |
HNSC | |
LUAD | 0.743 |
LUSC | |
non_ccRCC | |
PDAC | 0.394 |
UCEC |
ARAF-Ser272 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.419 |
GBM | -0.722 |
HNSC | |
LUAD | 1.141 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAF-Ser274 | |
---|---|
Cancer | Intensity |
BRCA | 1.153 |
COAD | |
HGSC | -0.524 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | -0.629 |
UCEC |
ARAF-Ser283 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | -0.241 |
HNSC | |
LUAD | -1.169 |
LUSC | 0.166 |
non_ccRCC | |
PDAC | |
UCEC | 1.244 |
ARAF-Ser458 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.707 |
LUSC | 0.707 |
non_ccRCC | |
PDAC | |
UCEC |
ARAF-Ser547 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 1.409 |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | -0.606 |
PDAC | 0.002 |
UCEC | -0.805 |
ARAF-Ser580 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | 0.842 |
HNSC | 0.264 |
LUAD | -1.105 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAF-Ser582 | |
---|---|
Cancer | Intensity |
BRCA | 0.196 |
COAD | -0.451 |
HGSC | 2.4 |
ccRCC | -0.101 |
GBM | 0.193 |
HNSC | -0.933 |
LUAD | -0.697 |
LUSC | 1.024 |
non_ccRCC | -1.173 |
PDAC | -0.414 |
UCEC | -0.045 |
ARAF-Ser600 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | 0.338 |
ccRCC | 0.231 |
GBM | 0.87 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -1.44 |
ARAF-Thr181 | |
---|---|
Cancer | Intensity |
BRCA | 0.887 |
COAD | 0.325 |
HGSC | -0.678 |
ccRCC | -0.188 |
GBM | 0.162 |
HNSC | 1.575 |
LUAD | -0.864 |
LUSC | 0.403 |
non_ccRCC | -2.079 |
PDAC | -0.392 |
UCEC | 0.849 |
ARAF-Thr213 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -1.154 |
GBM | 0.977 |
HNSC | 0.949 |
LUAD | -0.894 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.121 |
ARAF-Thr215 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -1.034 |
GBM | 1.27 |
HNSC | 0.525 |
LUAD | -0.995 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.234 |
ARAF-Thr223 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.517 |
GBM | 0.609 |
HNSC | -1.231 |
LUAD | -0.204 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 1.343 |
ARAF-Thr224 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 0.119 |
GBM | 1.417 |
HNSC | -0.603 |
LUAD | 0.301 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -1.235 |
ARAF-Thr253 | |
---|---|
Cancer | Intensity |
BRCA | -1.576 |
COAD | 0.667 |
HGSC | |
ccRCC | -0.843 |
GBM | |
HNSC | |
LUAD | -0.208 |
LUSC | |
non_ccRCC | 1.19 |
PDAC | 0.935 |
UCEC | -0.165 |
ARAF-Thr318 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | 1.045 |
ccRCC | 0.759 |
GBM | |
HNSC | |
LUAD | -0.637 |
LUSC | 0.206 |
non_ccRCC | |
PDAC | |
UCEC | -1.372 |
ARAF-Tyr155 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 0.707 |
GBM | |
HNSC | |
LUAD | -0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP1-Ser1007 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.707 |
GBM | |
HNSC | |
LUAD | 0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP1-Ser1324 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | -0.707 |
LUAD | |
LUSC | 0.707 |
non_ccRCC | |
PDAC | |
UCEC |
ARAP1-Ser1419 | |
---|---|
Cancer | Intensity |
BRCA | 0.148 |
COAD | 0.484 |
HGSC | 2.421 |
ccRCC | -0.604 |
GBM | -0.3 |
HNSC | 0.102 |
LUAD | 0.081 |
LUSC | 0.369 |
non_ccRCC | -0.426 |
PDAC | -1.64 |
UCEC | -0.636 |
ARAP1-Ser1428 | |
---|---|
Cancer | Intensity |
BRCA | 0.076 |
COAD | -0.204 |
HGSC | 1.446 |
ccRCC | 0.081 |
GBM | -0.118 |
HNSC | -0.211 |
LUAD | -0.402 |
LUSC | 0.173 |
non_ccRCC | 1.475 |
PDAC | -2.33 |
UCEC | 0.014 |
ARAP1-Ser1435 | |
---|---|
Cancer | Intensity |
BRCA | 0.397 |
COAD | 0.211 |
HGSC | 1.641 |
ccRCC | -0.145 |
GBM | 0.654 |
HNSC | -0.014 |
LUAD | -0.019 |
LUSC | -0.596 |
non_ccRCC | 0.91 |
PDAC | -0.864 |
UCEC | -2.174 |
ARAP1-Ser229 | |
---|---|
Cancer | Intensity |
BRCA | 1.066 |
COAD | 0.407 |
HGSC | -1.974 |
ccRCC | 0.24 |
GBM | -0.32 |
HNSC | 0.445 |
LUAD | 0.121 |
LUSC | 0.436 |
non_ccRCC | 0.172 |
PDAC | 1.123 |
UCEC | -1.717 |
ARAP1-Ser428 | |
---|---|
Cancer | Intensity |
BRCA | -0.645 |
COAD | -0.507 |
HGSC | 1.152 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP1-Ser497 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 0.108 |
GBM | |
HNSC | |
LUAD | 0.195 |
LUSC | 1.144 |
non_ccRCC | -1.617 |
PDAC | |
UCEC | 0.169 |
ARAP1-Ser630 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.595 |
HGSC | -1.155 |
ccRCC | |
GBM | |
HNSC | 0.56 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP1-Ser632 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | -0.707 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | 0.707 |
non_ccRCC | |
PDAC | |
UCEC |
ARAP1-Ser729 | |
---|---|
Cancer | Intensity |
BRCA | -0.407 |
COAD | 0.161 |
HGSC | 2.592 |
ccRCC | -0.435 |
GBM | -0.083 |
HNSC | -1.225 |
LUAD | -0.188 |
LUSC | 0.385 |
non_ccRCC | 0.428 |
PDAC | -0.248 |
UCEC | -0.981 |
ARAP1-Ser738 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -0.707 |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | 0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP1-Thr78 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 0.707 |
GBM | |
HNSC | |
LUAD | -0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP1-Thr791 | |
---|---|
Cancer | Intensity |
BRCA | 0.233 |
COAD | |
HGSC | 0.742 |
ccRCC | -1.874 |
GBM | |
HNSC | 1.261 |
LUAD | -0.432 |
LUSC | 0.264 |
non_ccRCC | |
PDAC | |
UCEC | -0.195 |
ARAP1-Thr931 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -1.099 |
GBM | |
HNSC | |
LUAD | |
LUSC | 0.857 |
non_ccRCC | |
PDAC | 0.241 |
UCEC |
ARAP1-Tyr231 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.407 |
HGSC | -1.545 |
ccRCC | |
GBM | |
HNSC | 1.177 |
LUAD | -0.192 |
LUSC | 0.153 |
non_ccRCC | |
PDAC | |
UCEC |
ARAP2-Ser1632 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.784 |
HGSC | |
ccRCC | |
GBM | 0.343 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | -1.126 |
PDAC | |
UCEC |
ARAP2-Ser261 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | 0.707 |
LUAD | -0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP2-Ser262 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | -0.931 |
HNSC | 1.47 |
LUAD | -0.742 |
LUSC | -0.346 |
non_ccRCC | 0.549 |
PDAC | |
UCEC |
ARAP2-Ser658 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | 1.138 |
HNSC | -0.738 |
LUAD | |
LUSC | |
non_ccRCC | -0.401 |
PDAC | |
UCEC |
ARAP2-Ser781 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | 0.707 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -0.707 |
ARAP2-Thr1639 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | 0.707 |
HNSC | -0.707 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP2-Tyr258 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | -1.469 |
HNSC | 0.761 |
LUAD | 0.427 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.281 |
ARAP2-Tyr77 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | -0.707 |
HNSC | |
LUAD | |
LUSC | 0.707 |
non_ccRCC | |
PDAC | |
UCEC |
ARAP3-Ser1337 | |
---|---|
Cancer | Intensity |
BRCA | 0.365 |
COAD | -0.438 |
HGSC | 1.581 |
ccRCC | |
GBM | -0.944 |
HNSC | -1.095 |
LUAD | -0.421 |
LUSC | 0.952 |
non_ccRCC | |
PDAC | |
UCEC |
ARAP3-Ser1338 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | -0.707 |
ccRCC | |
GBM | 0.707 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP3-Ser1380 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 1.143 |
HGSC | |
ccRCC | -0.712 |
GBM | -0.431 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP3-Ser1444 | |
---|---|
Cancer | Intensity |
BRCA | 1.722 |
COAD | 1.186 |
HGSC | -0.978 |
ccRCC | 0.047 |
GBM | -1.069 |
HNSC | 0.089 |
LUAD | 0.679 |
LUSC | 0.44 |
non_ccRCC | -1.659 |
PDAC | -0.159 |
UCEC | -0.298 |
ARAP3-Ser1480 | |
---|---|
Cancer | Intensity |
BRCA | -2.26 |
COAD | 0.246 |
HGSC | |
ccRCC | 0.314 |
GBM | 0.405 |
HNSC | 0.355 |
LUAD | 0.431 |
LUSC | 0.509 |
non_ccRCC | |
PDAC | |
UCEC |
ARAP3-Ser235 | |
---|---|
Cancer | Intensity |
BRCA | -0.151 |
COAD | -0.523 |
HGSC | 2.452 |
ccRCC | -0.029 |
GBM | -1.083 |
HNSC | |
LUAD | -0.164 |
LUSC | -0.046 |
non_ccRCC | -0.666 |
PDAC | 0.21 |
UCEC |
ARAP3-Ser462 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 0.641 |
GBM | -1.276 |
HNSC | |
LUAD | 1.306 |
LUSC | -0.46 |
non_ccRCC | -0.211 |
PDAC | |
UCEC |
ARAP3-Ser695 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | 0.707 |
HNSC | -0.707 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARAP3-Thr1348 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 1.607 |
HGSC | -1.019 |
ccRCC | 0.242 |
GBM | |
HNSC | |
LUAD | 0.416 |
LUSC | -0.191 |
non_ccRCC | |
PDAC | |
UCEC | -1.054 |
ARCN1-Ser132 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | 0.707 |
ccRCC | -0.707 |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARCN1-Ser220 | |
---|---|
Cancer | Intensity |
BRCA | -0.069 |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.558 |
LUSC | -0.841 |
non_ccRCC | |
PDAC | -0.24 |
UCEC | 1.708 |
ARCN1-Ser244 | |
---|---|
Cancer | Intensity |
BRCA | 1.294 |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | -0.98 |
LUAD | -0.338 |
LUSC | -0.778 |
non_ccRCC | |
PDAC | 0.803 |
UCEC |
ARCN1-Ser252 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | -0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.707 |
ARCN1-Ser253 | |
---|---|
Cancer | Intensity |
BRCA | -0.086 |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | 0.254 |
LUSC | 1.123 |
non_ccRCC | |
PDAC | |
UCEC | -1.291 |
ARCN1-Ser405 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | -0.272 |
HGSC | -0.836 |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | 1.108 |
PDAC | |
UCEC |
ARCN1-Ser493 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | -0.939 |
HNSC | |
LUAD | |
LUSC | 0.116 |
non_ccRCC | |
PDAC | 1.351 |
UCEC | -0.528 |
ARCN1-Ser74 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | 0.707 |
LUSC | -0.707 |
non_ccRCC | |
PDAC | |
UCEC |
ARCN1-Ser87 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | 0.707 |
LUSC | -0.707 |
non_ccRCC | |
PDAC | |
UCEC |
ARCN1-Thr248 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | 0.775 |
LUAD | 0.354 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -1.129 |
ARCN1-Thr349 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.707 |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | 0.707 |
PDAC | |
UCEC |
ARCN1-Thr437 | |
---|---|
Cancer | Intensity |
BRCA | 0.97 |
COAD | |
HGSC | |
ccRCC | |
GBM | -1.264 |
HNSC | 0.462 |
LUAD | 0.633 |
LUSC | 0.338 |
non_ccRCC | |
PDAC | 0.452 |
UCEC | -1.59 |
ARCN1-Thr487 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | 0.707 |
LUAD | -0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARCN1-Thr82 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | 0.707 |
LUSC | -0.707 |
non_ccRCC | |
PDAC | |
UCEC |
ARF4-Ser137 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | -0.475 |
HNSC | |
LUAD | -0.674 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 1.149 |
ARF5-Ser137 | |
---|---|
Cancer | Intensity |
BRCA | -0.707 |
COAD | |
HGSC | |
ccRCC | |
GBM | |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.707 |
ARFGAP1-Ser102 | |
---|---|
Cancer | Intensity |
BRCA | 1.887 |
COAD | |
HGSC | |
ccRCC | -1.042 |
GBM | -0.645 |
HNSC | 0.53 |
LUAD | 0.268 |
LUSC | -0.19 |
non_ccRCC | -1.187 |
PDAC | |
UCEC | 0.378 |
ARFGAP1-Ser106 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | |
GBM | -0.707 |
HNSC | |
LUAD | 0.707 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
ARFGAP1-Ser107 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 0.459 |
GBM | -0.435 |
HNSC | 1.619 |
LUAD | -1.312 |
LUSC | -0.703 |
non_ccRCC | -0.404 |
PDAC | |
UCEC | 0.776 |
ARFGAP1-Ser121 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 0.486 |
HGSC | |
ccRCC | -1.15 |
GBM | |
HNSC | |
LUAD | |
LUSC | 0.664 |
non_ccRCC | |
PDAC | |
UCEC |
ARFGAP1-Ser181 | |
---|---|
Cancer | Intensity |
BRCA | 1.686 |
COAD | |
HGSC | |
ccRCC | -0.814 |
GBM | 0.232 |
HNSC | -0.497 |
LUAD | 0.406 |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | -1.014 |
ARFGAP1-Ser184 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | 1.109 |
HGSC | -1.822 |
ccRCC | -0.145 |
GBM | 0.349 |
HNSC | -0.045 |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC | 0.554 |
ARFGAP1-Ser298 | |
---|---|
Cancer | Intensity |
BRCA | -0.445 |
COAD | -0.369 |
HGSC | -1.206 |
ccRCC | 0.871 |
GBM | -1.667 |
HNSC | 1.399 |
LUAD | 0.504 |
LUSC | 0.712 |
non_ccRCC | -0.584 |
PDAC | |
UCEC | 0.784 |
ARFGAP1-Ser300 | |
---|---|
Cancer | Intensity |
BRCA | -1.869 |
COAD | -0.187 |
HGSC | 1.015 |
ccRCC | 0.83 |
GBM | -0.102 |
HNSC | |
LUAD | 0.638 |
LUSC | |
non_ccRCC | -0.964 |
PDAC | |
UCEC | 0.638 |