Id: | acc0827 |
Group: | 2sens |
Protein: | S6 |
Gene Symbol: | RPS6 |
Protein Id: | P62753 |
Protein Name: | RS6_HUMAN |
PTM: | phosphorylation |
Site: | Thr389 |
Site Sequence: | ------------------------------------------------------------------------------------------------------------------------------------------------------- |
Disease Category: | Cancer |
Disease: | Colorectal Cancer |
Disease Subtype: | Colon Cancer |
Disease Cellline: | COLO205 |
Disease Info: | |
Drug: | trametinib |
Drug Info: | "Trametinib is a reversible inhibitor of mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2, used for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, either as a single agent or in combination with dabrafenib. " |
Effect: | inhibit |
Effect Info: | SHR8443 inhibits the phosphorylation of AKT and S6 in tumor tissues and overcomes the resistance to RAF/MEK inhibitors. |
Note: | |
Score: | 5.0 |
Pubmed(PMID): | 29296217 |
Sentence Index: | 29296217_6-7 |
Sentence: | "Compared with the well-known PI3K/mTOR inhibitor BEZ235, SHR8443 showed broader and stronger efficacy against carcinoma xenografts, including those resistant to anti-HER2 antibody trastuzumab, in association with the inhibition of AKT and S6 phosphorylation in tumor tissues, and also caused no noticeable toxicity. Thus, our preclinical data show that SHR8443 is a dual PI3K/mTOR inhibitor with pharmaceutical properties favorable for use as an anticancer agent." |
Sequence & Structure:
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK
Select PDB:
Target | Drug name | MOA | Phase | Status | Disease | Source |
---|---|---|---|---|---|---|
RPS6 | ATALUREN | 80S Ribosome modulator | 4 | - | Duchenne muscular dystrophy | EMA |
RPS6 | ATALUREN | 80S Ribosome modulator | 3 | Completed | Duchenne muscular dystrophy | ClinicalTrials ClinicalTrials ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 3 | Completed | cystic fibrosis | ClinicalTrials ClinicalTrials ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 3 | Terminated | cystic fibrosis | ClinicalTrials ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 3 | Completed | Becker muscular dystrophy | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 3 | Completed | qualitative or quantitative defects of dystrophin | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 3 | Enrolling by invitation | Duchenne muscular dystrophy | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 3 | Terminated | Duchenne muscular dystrophy | ClinicalTrials |
RPS6 | MT-3724 | 80S Ribosome inhibitor | 2 | Terminated | diffuse large B-cell lymphoma | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Completed | epilepsy | ClinicalTrials |
RPS6 | MT-3724 | 80S Ribosome inhibitor | 2 | Terminated | non-Hodgkins lymphoma | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Terminated | hemophilia A | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Completed | Duchenne muscular dystrophy | ClinicalTrials ClinicalTrials ClinicalTrials ClinicalTrials ClinicalTrials ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Terminated | Duchenne muscular dystrophy | ClinicalTrials ClinicalTrials ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Completed | cystic fibrosis | ClinicalTrials ClinicalTrials ClinicalTrials ClinicalTrials |
RPS6 | ELX-02 | 80S Ribosome modulator | 2 | Completed | cystic fibrosis | ClinicalTrials ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Terminated | Becker muscular dystrophy | ClinicalTrials ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Completed | Becker muscular dystrophy | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Terminated | hemophilia B | ClinicalTrials |
RPS6 | ELX-02 | 80S Ribosome modulator | 2 | Recruiting | Alport syndrome | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Completed | aniridia | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Withdrawn | aniridia | ClinicalTrials |
RPS6 | ELX-02 | 80S Ribosome modulator | 2 | Terminated | cystinosis | ClinicalTrials |
RPS6 | ATALUREN | 80S Ribosome modulator | 2 | Terminated | Disorder of amino acid and other organic acid metabolism | ClinicalTrials |
RPS6 | MT-3724 | 80S Ribosome inhibitor | 1 | Terminated | neoplasm of mature B-cells | ClinicalTrials |
Note: Only show clinically investigational or approved drugs with protein targets.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
RPS6-Ser148 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | 0.707 | ||||
HGSC | -0.707 | ||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6-Ser235 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.184 | ||||
COAD | |||||
HGSC | |||||
ccRCC | -0.383 | ||||
GBM | 0.073 | ||||
HNSC | 0.382 | ||||
LUAD | 0.449 | ||||
LUSC | 0.94 | ||||
non_ccRCC | -2.268 | ||||
PDAC | -0.16 | ||||
UCEC | -0.215 |
RPS6-Ser236 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.399 | ||||
COAD | 0.214 | ||||
HGSC | |||||
ccRCC | -0.441 | ||||
GBM | 0.023 | ||||
HNSC | 0.338 | ||||
LUAD | 0.407 | ||||
LUSC | 0.907 | ||||
non_ccRCC | -2.362 | ||||
PDAC | -0.214 | ||||
UCEC | -0.27 |
RPS6-Ser240 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.329 | ||||
COAD | -0.99 | ||||
HGSC | 0.145 | ||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | -0.484 | ||||
UCEC |
RPS6-Ser242 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.542 | ||||
HGSC | 1.154 | ||||
ccRCC | |||||
GBM | |||||
HNSC | -0.612 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6-Ser82 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | -0.321 | ||||
HNSC | -0.485 | ||||
LUAD | -0.564 | ||||
LUSC | 2.03 | ||||
non_ccRCC | |||||
PDAC | -0.381 | ||||
UCEC | -0.278 |
RPS6-Tyr84 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.503 | ||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | -0.443 | ||||
LUSC | 1.498 | ||||
non_ccRCC | |||||
PDAC | -0.552 | ||||
UCEC |
RPS6KA1-Ser218 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | 0.707 | ||||
UCEC | -0.707 |
RPS6KA1-Ser230 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | 0.199 | ||||
HGSC | 1.332 | ||||
ccRCC | |||||
GBM | |||||
HNSC | -0.855 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -0.676 |
RPS6KA1-Ser28 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.311 | ||||
GBM | |||||
HNSC | |||||
LUAD | -0.05 | ||||
LUSC | -1.328 | ||||
non_ccRCC | |||||
PDAC | 1.067 | ||||
UCEC |
RPS6KA1-Ser372 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.233 | ||||
COAD | -0.684 | ||||
HGSC | 2.371 | ||||
ccRCC | -0.505 | ||||
GBM | 0.694 | ||||
HNSC | -0.745 | ||||
LUAD | -0.088 | ||||
LUSC | 0.644 | ||||
non_ccRCC | -1.42 | ||||
PDAC | -0.202 | ||||
UCEC | -0.296 |
RPS6KA1-Ser378 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.001 | ||||
COAD | -1.356 | ||||
HGSC | |||||
ccRCC | -1.574 | ||||
GBM | 1.362 | ||||
HNSC | 1.141 | ||||
LUAD | 0.66 | ||||
LUSC | 0.113 | ||||
non_ccRCC | -0.073 | ||||
PDAC | |||||
UCEC | -0.27 |
RPS6KA1-Ser389 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.926 | ||||
COAD | -0.393 | ||||
HGSC | 2.613 | ||||
ccRCC | -0.217 | ||||
GBM | -0.311 | ||||
HNSC | -0.007 | ||||
LUAD | -0.099 | ||||
LUSC | 0.478 | ||||
non_ccRCC | -1.325 | ||||
PDAC | 0.04 | ||||
UCEC | 0.147 |
RPS6KA1-Ser522 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | -0.791 | ||||
LUSC | |||||
non_ccRCC | 1.124 | ||||
PDAC | |||||
UCEC | -0.333 |
RPS6KA1-Ser54 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.476 | ||||
GBM | |||||
HNSC | -1.836 | ||||
LUAD | 0.264 | ||||
LUSC | 0.576 | ||||
non_ccRCC | -0.041 | ||||
PDAC | -0.68 | ||||
UCEC | 1.24 |
RPS6KA1-Ser693 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.707 | ||||
GBM | |||||
HNSC | -0.707 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA1-Ser696 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.042 | ||||
COAD | -1.377 | ||||
HGSC | |||||
ccRCC | -0.299 | ||||
GBM | 2.161 | ||||
HNSC | -0.573 | ||||
LUAD | -0.925 | ||||
LUSC | -0.023 | ||||
non_ccRCC | 1.027 | ||||
PDAC | 0.212 | ||||
UCEC | -0.244 |
RPS6KA1-Ser81 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.665 | ||||
GBM | |||||
HNSC | |||||
LUAD | 0.358 | ||||
LUSC | 0.464 | ||||
non_ccRCC | -1.488 | ||||
PDAC | |||||
UCEC |
RPS6KA1-Thr234 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.481 | ||||
COAD | -0.141 | ||||
HGSC | 2.489 | ||||
ccRCC | -0.603 | ||||
GBM | -0.123 | ||||
HNSC | 0.098 | ||||
LUAD | -0.085 | ||||
LUSC | 0.818 | ||||
non_ccRCC | -1.463 | ||||
PDAC | -0.584 | ||||
UCEC | 0.076 |
RPS6KA1-Thr368 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -1.456 | ||||
COAD | 0.005 | ||||
HGSC | |||||
ccRCC | -0.039 | ||||
GBM | 0.705 | ||||
HNSC | -1.287 | ||||
LUAD | -0.001 | ||||
LUSC | 1.758 | ||||
non_ccRCC | -0.385 | ||||
PDAC | |||||
UCEC | 0.7 |
RPS6KA1-Thr393 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.738 | ||||
HGSC | 0.361 | ||||
ccRCC | -0.874 | ||||
GBM | |||||
HNSC | 1.25 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA1-Thr582 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.952 | ||||
COAD | 0.136 | ||||
HGSC | 0.538 | ||||
ccRCC | -0.595 | ||||
GBM | 2.708 | ||||
HNSC | -0.471 | ||||
LUAD | -0.299 | ||||
LUSC | 0.054 | ||||
non_ccRCC | -0.367 | ||||
PDAC | -0.806 | ||||
UCEC | 0.054 |
RPS6KA1-Thr586 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.066 | ||||
HGSC | 1.854 | ||||
ccRCC | -0.583 | ||||
GBM | |||||
HNSC | 0.095 | ||||
LUAD | -0.224 | ||||
LUSC | |||||
non_ccRCC | -1.076 | ||||
PDAC | |||||
UCEC |
RPS6KA1-Tyr237 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | 0.707 | ||||
HGSC | -0.707 | ||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA1-Tyr585 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.524 | ||||
HGSC | 1.411 | ||||
ccRCC | -0.489 | ||||
GBM | 0.03 | ||||
HNSC | 0.273 | ||||
LUAD | 0.909 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -1.61 |
RPS6KA2-Ser214 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | 0.707 | ||||
UCEC | -0.707 |
RPS6KA2-Ser385 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.65 | ||||
HGSC | |||||
ccRCC | |||||
GBM | -0.116 | ||||
HNSC | |||||
LUAD | 0.488 | ||||
LUSC | -1.143 | ||||
non_ccRCC | 1.421 | ||||
PDAC | |||||
UCEC |
RPS6KA2-Ser389 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | 0.707 | ||||
LUAD | -0.707 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA2-Thr230 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | 0.596 | ||||
HNSC | |||||
LUAD | -0.205 | ||||
LUSC | 0.928 | ||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -1.319 |
RPS6KA2-Thr578 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.881 | ||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | 1.087 | ||||
LUSC | |||||
non_ccRCC | -0.205 | ||||
PDAC | |||||
UCEC |
RPS6KA2-Tyr685 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | -0.707 | ||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | 0.707 |
RPS6KA3-Ser19 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.707 | ||||
HGSC | |||||
ccRCC | 0.707 | ||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA3-Ser215 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | 0.707 | ||||
UCEC | -0.707 |
RPS6KA3-Ser227 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | 0.199 | ||||
HGSC | 1.332 | ||||
ccRCC | |||||
GBM | |||||
HNSC | -0.855 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -0.676 |
RPS6KA3-Ser369 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.255 | ||||
COAD | -0.304 | ||||
HGSC | 2.077 | ||||
ccRCC | -0.493 | ||||
GBM | 0.043 | ||||
HNSC | -0.148 | ||||
LUAD | -0.202 | ||||
LUSC | 1.061 | ||||
non_ccRCC | -2.014 | ||||
PDAC | 0.193 | ||||
UCEC | 0.044 |
RPS6KA3-Ser375 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -2.039 | ||||
COAD | 0.872 | ||||
HGSC | |||||
ccRCC | 0.187 | ||||
GBM | -0.227 | ||||
HNSC | 0.737 | ||||
LUAD | 0.914 | ||||
LUSC | 0.448 | ||||
non_ccRCC | -1.469 | ||||
PDAC | 0.502 | ||||
UCEC | 0.074 |
RPS6KA3-Ser386 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.989 | ||||
COAD | -0.384 | ||||
HGSC | |||||
ccRCC | -0.448 | ||||
GBM | -0.368 | ||||
HNSC | 0.525 | ||||
LUAD | 0.047 | ||||
LUSC | 0.227 | ||||
non_ccRCC | -0.822 | ||||
PDAC | -0.324 | ||||
UCEC | 2.535 |
RPS6KA3-Ser396 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | -0.707 | ||||
LUAD | 0.707 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA3-Ser415 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -2.52 | ||||
COAD | 0.206 | ||||
HGSC | 1.033 | ||||
ccRCC | 0.431 | ||||
GBM | 0.057 | ||||
HNSC | 0.342 | ||||
LUAD | 0.285 | ||||
LUSC | 0.06 | ||||
non_ccRCC | 0.766 | ||||
PDAC | 0.491 | ||||
UCEC | -1.15 |
RPS6KA3-Ser715 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.161 | ||||
COAD | 0.129 | ||||
HGSC | 1.234 | ||||
ccRCC | 0.088 | ||||
GBM | -0.371 | ||||
HNSC | 1.479 | ||||
LUAD | -2.181 | ||||
LUSC | 0.783 | ||||
non_ccRCC | 0.161 | ||||
PDAC | -0.452 | ||||
UCEC | -0.709 |
RPS6KA3-Ser78 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.665 | ||||
GBM | |||||
HNSC | |||||
LUAD | 0.358 | ||||
LUSC | 0.464 | ||||
non_ccRCC | -1.488 | ||||
PDAC | |||||
UCEC |
RPS6KA3-Thr231 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.48 | ||||
COAD | -0.14 | ||||
HGSC | 2.49 | ||||
ccRCC | -0.603 | ||||
GBM | -0.122 | ||||
HNSC | 0.09 | ||||
LUAD | -0.084 | ||||
LUSC | 0.819 | ||||
non_ccRCC | -1.463 | ||||
PDAC | -0.583 | ||||
UCEC | 0.077 |
RPS6KA3-Thr365 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.677 | ||||
COAD | -0.279 | ||||
HGSC | 2.645 | ||||
ccRCC | -0.354 | ||||
GBM | -0.114 | ||||
HNSC | -0.074 | ||||
LUAD | -0.24 | ||||
LUSC | 0.427 | ||||
non_ccRCC | -1.44 | ||||
PDAC | -0.006 | ||||
UCEC | 0.112 |
RPS6KA3-Thr577 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.952 | ||||
COAD | 0.136 | ||||
HGSC | 0.538 | ||||
ccRCC | -0.595 | ||||
GBM | 2.708 | ||||
HNSC | -0.471 | ||||
LUAD | -0.299 | ||||
LUSC | 0.054 | ||||
non_ccRCC | -0.367 | ||||
PDAC | -0.806 | ||||
UCEC | 0.054 |
RPS6KA3-Thr581 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.066 | ||||
HGSC | 1.854 | ||||
ccRCC | -0.583 | ||||
GBM | |||||
HNSC | 0.095 | ||||
LUAD | -0.224 | ||||
LUSC | |||||
non_ccRCC | -1.076 | ||||
PDAC | |||||
UCEC |
RPS6KA3-Tyr234 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.971 | ||||
COAD | 0.41 | ||||
HGSC | -0.822 | ||||
ccRCC | 0.314 | ||||
GBM | |||||
HNSC | 0.834 | ||||
LUAD | 0.151 | ||||
LUSC | -0.301 | ||||
non_ccRCC | -2.209 | ||||
PDAC | 0.653 | ||||
UCEC |
RPS6KA3-Tyr580 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.524 | ||||
HGSC | 1.411 | ||||
ccRCC | -0.489 | ||||
GBM | 0.03 | ||||
HNSC | 0.273 | ||||
LUAD | 0.909 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -1.61 |
RPS6KA4-Ser196 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | 0.707 | ||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | -0.707 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA4-Ser324 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | 0.707 | ||||
LUSC | |||||
non_ccRCC | -0.707 | ||||
PDAC | |||||
UCEC |
RPS6KA4-Ser343 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.444 | ||||
HGSC | -0.405 | ||||
ccRCC | -0.939 | ||||
GBM | |||||
HNSC | |||||
LUAD | 1.655 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | 0.133 |
RPS6KA4-Ser347 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -1.576 | ||||
COAD | -0.393 | ||||
HGSC | -1.669 | ||||
ccRCC | 0.108 | ||||
GBM | 0.057 | ||||
HNSC | 0.923 | ||||
LUAD | 0.922 | ||||
LUSC | 1.571 | ||||
non_ccRCC | -0.416 | ||||
PDAC | 0.466 | ||||
UCEC | 0.008 |
RPS6KA4-Ser360 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | 0.371 | ||||
HGSC | |||||
ccRCC | 0.761 | ||||
GBM | |||||
HNSC | |||||
LUAD | -1.132 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA4-Ser427 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.084 | ||||
GBM | |||||
HNSC | -0.889 | ||||
LUAD | -0.799 | ||||
LUSC | 1.602 | ||||
non_ccRCC | |||||
PDAC | 0.002 | ||||
UCEC |
RPS6KA4-Ser628 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.139 | ||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | -0.541 | ||||
LUAD | 0.271 | ||||
LUSC | 0.457 | ||||
non_ccRCC | 0.397 | ||||
PDAC | -1.723 | ||||
UCEC |
RPS6KA4-Ser666 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.707 | ||||
GBM | |||||
HNSC | -0.707 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA4-Ser672 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.511 | ||||
HGSC | 1.497 | ||||
ccRCC | -0.415 | ||||
GBM | |||||
HNSC | -0.571 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA4-Ser675 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.151 | ||||
GBM | |||||
HNSC | -1.067 | ||||
LUAD | 0.916 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA4-Ser676 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.555 | ||||
HGSC | 2.167 | ||||
ccRCC | -0.537 | ||||
GBM | 0.178 | ||||
HNSC | -0.397 | ||||
LUAD | -0.149 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -0.707 |
RPS6KA4-Ser715 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 2.005 | ||||
COAD | 0.871 | ||||
HGSC | |||||
ccRCC | 0.372 | ||||
GBM | 0.047 | ||||
HNSC | -0.041 | ||||
LUAD | -0.146 | ||||
LUSC | -0.063 | ||||
non_ccRCC | -0.639 | ||||
PDAC | -0.59 | ||||
UCEC | -1.816 |
RPS6KA4-Ser731 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.181 | ||||
COAD | |||||
HGSC | 2.352 | ||||
ccRCC | -0.05 | ||||
GBM | |||||
HNSC | -0.665 | ||||
LUAD | -0.521 | ||||
LUSC | |||||
non_ccRCC | -0.303 | ||||
PDAC | -0.24 | ||||
UCEC | -0.754 |
RPS6KA4-Ser739 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.305 | ||||
COAD | -0.318 | ||||
HGSC | 2.006 | ||||
ccRCC | -0.002 | ||||
GBM | -1.495 | ||||
HNSC | -0.449 | ||||
LUAD | -0.039 | ||||
LUSC | 0.281 | ||||
non_ccRCC | 1.522 | ||||
PDAC | -0.26 | ||||
UCEC | -0.939 |
RPS6KA4-Thr22 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.583 | ||||
COAD | 0.096 | ||||
HGSC | 2.1 | ||||
ccRCC | 0.142 | ||||
GBM | |||||
HNSC | -0.848 | ||||
LUAD | -0.29 | ||||
LUSC | -0.293 | ||||
non_ccRCC | |||||
PDAC | 0.036 | ||||
UCEC | -1.526 |
RPS6KA4-Thr681 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.185 | ||||
COAD | -0.107 | ||||
HGSC | 2.543 | ||||
ccRCC | -0.339 | ||||
GBM | 0.659 | ||||
HNSC | -0.152 | ||||
LUAD | -0.452 | ||||
LUSC | -0.578 | ||||
non_ccRCC | 0.101 | ||||
PDAC | -1.494 | ||||
UCEC | -0.366 |
RPS6KA4-Thr733 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.707 | ||||
HGSC | 0.707 | ||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA4-Tyr532 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | 0.707 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -0.707 |
RPS6KA5-Ser176 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.707 | ||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | 0.707 |
RPS6KA5-Ser340 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.707 | ||||
HGSC | 0.707 | ||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA5-Ser448 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.483 | ||||
COAD | |||||
HGSC | |||||
ccRCC | -0.363 | ||||
GBM | |||||
HNSC | |||||
LUAD | -0.413 | ||||
LUSC | -0.707 | ||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA5-Thr216 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.791 | ||||
GBM | |||||
HNSC | |||||
LUAD | -1.124 | ||||
LUSC | 0.333 | ||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KA5-Thr38 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.5 | ||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | 0.303 | ||||
HNSC | |||||
LUAD | 1.047 | ||||
LUSC | -0.272 | ||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -1.578 |
RPS6KB1-Ser371 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.707 | ||||
HGSC | |||||
ccRCC | 0.707 | ||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KB1-Ser375 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.707 | ||||
GBM | |||||
HNSC | -0.707 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KB1-Ser418 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.189 | ||||
COAD | 0.616 | ||||
HGSC | 1.605 | ||||
ccRCC | -2.354 | ||||
GBM | -0.189 | ||||
HNSC | 0.25 | ||||
LUAD | 0.135 | ||||
LUSC | 0.115 | ||||
non_ccRCC | |||||
PDAC | -0.404 | ||||
UCEC | 0.416 |
RPS6KB1-Ser424 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.557 | ||||
COAD | 1.149 | ||||
HGSC | 1.838 | ||||
ccRCC | -1.833 | ||||
GBM | 0.084 | ||||
HNSC | 0.253 | ||||
LUAD | -0.453 | ||||
LUSC | -0.048 | ||||
non_ccRCC | |||||
PDAC | -0.577 | ||||
UCEC | 0.145 |
RPS6KB1-Ser429 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.199 | ||||
COAD | |||||
HGSC | 1.767 | ||||
ccRCC | |||||
GBM | -0.531 | ||||
HNSC | |||||
LUAD | |||||
LUSC | -0.418 | ||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -0.618 |
RPS6KB1-Thr376 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.707 | ||||
GBM | |||||
HNSC | -0.707 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KB1-Thr389 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.707 | ||||
GBM | -0.707 | ||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KB1-Thr421 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -1.122 | ||||
COAD | 1.552 | ||||
HGSC | |||||
ccRCC | -1.395 | ||||
GBM | -0.379 | ||||
HNSC | 0.47 | ||||
LUAD | -0.284 | ||||
LUSC | 0.124 | ||||
non_ccRCC | |||||
PDAC | -0.319 | ||||
UCEC | 1.351 |
RPS6KB2-Ser370 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.707 | ||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | 0.707 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KB2-Ser416 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -2.003 | ||||
COAD | |||||
HGSC | |||||
ccRCC | 0.431 | ||||
GBM | |||||
HNSC | 0.572 | ||||
LUAD | -0.371 | ||||
LUSC | 0.898 | ||||
non_ccRCC | |||||
PDAC | -0.221 | ||||
UCEC | 0.694 |
RPS6KB2-Ser417 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -2.069 | ||||
COAD | -0.427 | ||||
HGSC | |||||
ccRCC | 0.592 | ||||
GBM | |||||
HNSC | 0.653 | ||||
LUAD | -0.343 | ||||
LUSC | 0.998 | ||||
non_ccRCC | |||||
PDAC | -0.185 | ||||
UCEC | 0.782 |
RPS6KB2-Ser423 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -1.811 | ||||
COAD | 1.399 | ||||
HGSC | |||||
ccRCC | -0.01 | ||||
GBM | |||||
HNSC | 0.155 | ||||
LUAD | 0.098 | ||||
LUSC | 1.125 | ||||
non_ccRCC | |||||
PDAC | -0.534 | ||||
UCEC | -0.421 |
RPS6KC1-Ser189 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | -0.707 | ||||
GBM | |||||
HNSC | |||||
LUAD | 0.707 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KC1-Ser190 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | -0.727 | ||||
GBM | |||||
HNSC | 1.14 | ||||
LUAD | -0.414 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KC1-Ser197 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | -0.509 | ||||
GBM | -0.406 | ||||
HNSC | 0.951 | ||||
LUAD | 1.622 | ||||
LUSC | 0.186 | ||||
non_ccRCC | -1.313 | ||||
PDAC | |||||
UCEC | -0.53 |
RPS6KC1-Ser269 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.144 | ||||
HGSC | 0.582 | ||||
ccRCC | |||||
GBM | 0.909 | ||||
HNSC | -1.347 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KC1-Ser270 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.354 | ||||
COAD | -0.017 | ||||
HGSC | -1.24 | ||||
ccRCC | |||||
GBM | |||||
HNSC | 0.509 | ||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -0.608 |
RPS6KC1-Ser411 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 2.387 | ||||
COAD | 0.436 | ||||
HGSC | 0.167 | ||||
ccRCC | -0.77 | ||||
GBM | -1.192 | ||||
HNSC | -0.814 | ||||
LUAD | -0.221 | ||||
LUSC | -0.385 | ||||
non_ccRCC | 0.888 | ||||
PDAC | 0.138 | ||||
UCEC | -0.634 |
RPS6KC1-Ser415 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.663 | ||||
COAD | 0.316 | ||||
HGSC | -2.558 | ||||
ccRCC | 0.214 | ||||
GBM | -0.255 | ||||
HNSC | -0.484 | ||||
LUAD | 0.596 | ||||
LUSC | 1.244 | ||||
non_ccRCC | 0.509 | ||||
PDAC | 0.314 | ||||
UCEC | -0.56 |
RPS6KC1-Ser436 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.116 | ||||
GBM | -1.661 | ||||
HNSC | 0.534 | ||||
LUAD | 0.041 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | 0.97 |
RPS6KC1-Ser437 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.598 | ||||
COAD | 0.098 | ||||
HGSC | -1.55 | ||||
ccRCC | |||||
GBM | -0.185 | ||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | -0.01 | ||||
PDAC | |||||
UCEC | 0.048 |
RPS6KC1-Ser449 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | -0.636 | ||||
ccRCC | 0.306 | ||||
GBM | -1.295 | ||||
HNSC | |||||
LUAD | -0.856 | ||||
LUSC | 1.652 | ||||
non_ccRCC | 0.316 | ||||
PDAC | |||||
UCEC | 0.513 |
RPS6KC1-Ser516 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.127 | ||||
COAD | -2.454 | ||||
HGSC | 0.155 | ||||
ccRCC | -0.193 | ||||
GBM | -0.351 | ||||
HNSC | 0.288 | ||||
LUAD | 0.06 | ||||
LUSC | 0.76 | ||||
non_ccRCC | 0.053 | ||||
PDAC | 1.201 | ||||
UCEC | -0.646 |
RPS6KC1-Ser546 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | 0.38 | ||||
GBM | 1.215 | ||||
HNSC | -0.565 | ||||
LUAD | -1.03 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KC1-Ser548 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | 0.746 | ||||
ccRCC | |||||
GBM | 0.39 | ||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | -1.136 | ||||
UCEC |
RPS6KC1-Ser570 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -1.454 | ||||
HGSC | 0.138 | ||||
ccRCC | |||||
GBM | 0.639 | ||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | 0.677 |
RPS6KC1-Ser571 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | -0.88 | ||||
HGSC | 1.435 | ||||
ccRCC | |||||
GBM | -0.357 | ||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -0.198 |
RPS6KC1-Ser584 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.121 | ||||
COAD | -0.189 | ||||
HGSC | 2.94 | ||||
ccRCC | -0.34 | ||||
GBM | -0.228 | ||||
HNSC | -0.123 | ||||
LUAD | -0.757 | ||||
LUSC | -0.42 | ||||
non_ccRCC | -0.449 | ||||
PDAC | -0.372 | ||||
UCEC | -0.184 |
RPS6KC1-Ser593 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.729 | ||||
COAD | 0.654 | ||||
HGSC | |||||
ccRCC | -0.146 | ||||
GBM | -0.406 | ||||
HNSC | -0.14 | ||||
LUAD | 0.416 | ||||
LUSC | 1.15 | ||||
non_ccRCC | 0.897 | ||||
PDAC | 0.583 | ||||
UCEC | -2.28 |
RPS6KC1-Ser596 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -0.352 | ||||
COAD | 0.789 | ||||
HGSC | |||||
ccRCC | -0.09 | ||||
GBM | -0.845 | ||||
HNSC | -0.714 | ||||
LUAD | 0.184 | ||||
LUSC | 0.578 | ||||
non_ccRCC | 1.859 | ||||
PDAC | 0.345 | ||||
UCEC | -1.755 |
RPS6KC1-Ser598 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | 0.707 | ||||
HGSC | |||||
ccRCC | -0.707 | ||||
GBM | |||||
HNSC | |||||
LUAD | |||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KC1-Ser628 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.707 | ||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | |||||
HNSC | |||||
LUAD | -0.707 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | |||||
UCEC |
RPS6KC1-Ser632 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -1.983 | ||||
COAD | 0.095 | ||||
HGSC | -0.579 | ||||
ccRCC | 0.025 | ||||
GBM | 0.599 | ||||
HNSC | -0.658 | ||||
LUAD | 0.178 | ||||
LUSC | 0.157 | ||||
non_ccRCC | 2.186 | ||||
PDAC | 0.212 | ||||
UCEC | -0.232 |
RPS6KC1-Ser649 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.779 | ||||
COAD | 0.743 | ||||
HGSC | |||||
ccRCC | -0.775 | ||||
GBM | -0.53 | ||||
HNSC | |||||
LUAD | -0.558 | ||||
LUSC | 0.331 | ||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -0.99 |
RPS6KC1-Ser652 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | 0.369 | ||||
HGSC | -2.416 | ||||
ccRCC | 0.254 | ||||
GBM | 0.043 | ||||
HNSC | 0.52 | ||||
LUAD | 0.137 | ||||
LUSC | |||||
non_ccRCC | |||||
PDAC | 0.74 | ||||
UCEC | 0.352 |
RPS6KC1-Ser655 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 0.283 | ||||
COAD | -0.475 | ||||
HGSC | 2.861 | ||||
ccRCC | -0.544 | ||||
GBM | -0.389 | ||||
HNSC | 0.282 | ||||
LUAD | -0.378 | ||||
LUSC | -0.631 | ||||
non_ccRCC | -0.563 | ||||
PDAC | -0.115 | ||||
UCEC | -0.329 |
RPS6KC1-Ser750 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | |||||
COAD | |||||
HGSC | |||||
ccRCC | |||||
GBM | 0.554 | ||||
HNSC | 0.803 | ||||
LUAD | -0.186 | ||||
LUSC | -1.665 | ||||
non_ccRCC | 0.493 | ||||
PDAC | |||||
UCEC |
RPS6KC1-Ser860 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | -1.779 | ||||
COAD | |||||
HGSC | |||||
ccRCC | 0.895 | ||||
GBM | 0.318 | ||||
HNSC | -1.037 | ||||
LUAD | -0.903 | ||||
LUSC | 0.988 | ||||
non_ccRCC | 0.45 | ||||
PDAC | 0.918 | ||||
UCEC | 0.15 |
RPS6KC1-Thr647 | |||||
---|---|---|---|---|---|
Cancer | Intensity | ||||
BRCA | 1.814 | ||||
COAD | |||||
HGSC | |||||
ccRCC | -0.458 | ||||
GBM | -0.758 | ||||
HNSC | |||||
LUAD | -0.475 | ||||
LUSC | 0.526 | ||||
non_ccRCC | |||||
PDAC | |||||
UCEC | -0.65 |
RPS6KC1-Thr847 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | -0.772 |
GBM | |
HNSC | |
LUAD | 1.13 |
LUSC | -0.357 |
non_ccRCC | |
PDAC | |
UCEC |
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
- | - | A | Focal segmental glomerulosclerosis | Phosphorylation | 35483522 |
S | 235 | D | Systemic lupus erythematosus | Phosphorylation | 34522717 |
S | 235 | D | Status epilepticus | Phosphorylation | 32833881 |
S | 236 | D | Status epilepticus | Phosphorylation | 32833881 |
S | 236 | D | Systemic lupus erythematosus | Phosphorylation | 34522717 |
S | 244 | U | Liver cancer | Phosphorylation | 23537100 |
S | 240 | U | Liver cancer | Phosphorylation | 23537100 |
- | - | U | Ehrlich ascites tumor | Phosphorylation | 208946 |
- | - | U | Renal cancer/carcinoma | Phosphorylation | 16247451 |
- | - | U | Esophageal squamous cell carcinoma | Phosphorylation | 22996377 |
- | - | U | Bladder cancer | Phosphorylation | 23273076 |
S | 244 | U | Tuberous sclerosis complex | Phosphorylation | 17671177 |
S | 240 | U | Tuberous sclerosis complex | Phosphorylation | 17671177 |
S | 236 | U | Non-small cell lung cancer | Phosphorylation | 35596155 |
S | 236 | U | Kaposi's sarcoma | Phosphorylation | 21819957 |
S | 235 | U | Non-small cell lung cancer | Phosphorylation | 35596155 |
S | 235 | U | Kaposi's sarcoma | Phosphorylation | 21819957 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.