| Id: | acc0858 |
| Group: | 2sens |
| Protein: | Chk1 |
| Gene Symbol: | Chek1 |
| Protein Id: | O35280 |
| Protein Name: | CHK1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser345 |
| Site Sequence: | DKLVQGISFSQPTCPEHMLVN |
| Disease Category: | Cancer |
| Disease: | Skin Cancer |
| Disease Subtype: | |
| Disease Cellline: | SKH-1 mice |
| Disease Info: | |
| Drug: | caffeine |
| Drug Info: | "A purine alkaloid acting as a central nervous system stimulant by antagonizing adenosine receptors, clinically applied for treating respiratory depression, enhancing analgesia in headache medications, and managing neonatal apnea. " |
| Effect: | modulate |
| Effect Info: | Taking caffeine can inhibit ATR-mediated Chk1 phosphorylation to enhance the removal of DNA-damaged cells. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 18381462 |
| Sentence Index: | 18381462_10-11 |
| Sentence: | The ability of caffeine to promote the deletion of p53(-/-) keratinocytes may be relevant to its inhibitory effect on UVB-induced skin cancer. Our studies indicate that administration of caffeine enhances the removal of DNA-damaged cells by inhibiting the ATR-mediated phosphorylation of Chk1 and prematurely increasing the number of cyclin B1-containing cells that undergo lethal mitosis. |
Sequence & Structure:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCPENIKKEICINKMLSHENVVKFYGHRREGHIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVETPSARITIPDIKKDRWYNKPLNRGAKRPRATSGGMSESSSGFSKHIHSNLDFSPVNNGSSEETVKFSSSQPEPRTGLSLWDTGPSNVDKLVQGISFSQPTCPEHMLVNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETFEKLGYQWKKSCMNQVTVSTTDRRNNKLIFKINLVEMDEKILVDFRLSKGDGLEFKRHFLKIKGKLSDVVSSQKVWFPVT
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
