| Id: | acc1051 |
| Group: | 2sens |
| Protein: | cdc25A |
| Gene Symbol: | CDC25A |
| Protein Id: | P30304 |
| Protein Name: | MPIP1_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser17 |
| Site Sequence: | PHRRRLLFACSPPPASQPVVK |
| Disease Category: | Cancer |
| Disease: | Prostate Cancer |
| Disease Subtype: | |
| Disease Cellline: | DU145 |
| Disease Info: | |
| Drug: | gallic acid |
| Drug Info: | "Gallic acid is a natural phenolic compound with antioxidant, anti-inflammatory, and potential anticancer properties, studied for its therapeutic effects in various preclinical models but not yet approved as a standalone drug." |
| Effect: | modulate |
| Effect Info: | "Gallic acid causes the phosphorylation of cdc25A/cdc25C - cdc2 through ATM - Chk2 activation, leading to cell cycle arrest and inducing apoptosis in human prostate cancer DU145 cells." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 17172433 |
| Sentence Index: | 17172433_0-1 |
| Sentence: | "Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells. We recently reported that gallic acid is a major active agent responsible for grape seed extract activity in DU145 human prostate carcinoma cells." |
Sequence & Structure:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
