| Id: | acc1085 |
| Group: | 2sens |
| Protein: | beta-catenin |
| Gene Symbol: | Ctnnb1 |
| Protein Id: | Q02248 |
| Protein Name: | CTNB1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser33 |
| Site Sequence: | HWQQQSYLDSGIHSGATTTAP |
| Disease Category: | Cancer |
| Disease: | Melanoma |
| Disease Subtype: | |
| Disease Cellline: | B16 |
| Disease Info: | |
| Drug: | imidazole |
| Drug Info: | - |
| Effect: | modulate |
| Effect Info: | "Imidazole increases the phosphorylation of beta-catenin and subsequent degradation of beta-catenin, thereby inhibiting the migration of melanoma cells." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 20604839 |
| Sentence Index: | 20604839_8-9 |
| Sentence: | "Western blot analysis demonstrated that imidazole increases phosphorylation of beta-catenin and subsequent degradation of beta-catenin. Moreover, inhibition of melanoma cell migration by imidazole was restored by MG132, a proteasome inhibitor, via inhibition of beta-catenin degradation." |
Sequence & Structure:
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEALGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 45 | D | Esophageal carcinoma | Phosphorylation | 31934197 |
| S | 37 | P | Acute myeloid leukemia/acute myelogenous leukemia | Phosphorylation | 21156284 |
| T | 41 | P | Acute myeloid leukemia/acute myelogenous leukemia | Phosphorylation | 21156284 |
| S | 45 | U | Esophageal carcinoma | Phosphorylation | 31934197 |
| S | 552 | U | Cowden syndrome | Phosphorylation | 17237784 |
| Y | 654 | U | Idiopathic pulmonary fibrosis | Phosphorylation | 19104148 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
