| Id: | acc1153 |
| Group: | 2sens |
| Protein: | FOXO3a |
| Gene Symbol: | Foxo3 |
| Protein Id: | Q9WVH4 |
| Protein Name: | FOXO3_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser253 |
| Site Sequence: | KAPRRRAVSMDNSNKYTKSRG |
| Disease Category: | Cancer |
| Disease: | Ovarian Cancer |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | melatonin + cisplatin |
| Drug Info: | Melatonin is a hormone that regulates sleep-wake cycles and is used to improve sleep quality or alleviate jet lag. Cisplatin is a platinum-based chemotherapeutic agent used to treat various cancers by interfering with DNA replication and inducing apoptosis in cancer cells. |
| Effect: | modulate |
| Effect Info: | "Melatonin inhibits the phosphorylation of members of the PTEN/AKT/FOXO3a pathway induced by cisplatin, thereby preventing cisplatin-induced primordial follicle loss during chemotherapy." |
| Note: | drug comb |
| Score: | 4.0 |
| Pubmed(PMID): | 26882203 |
| Sentence Index: | 26882203_8-9 |
| Sentence: | "Additionally, we show that melatonin inhibited the cisplatin-induced inhibitory phosphorylation and nuclear export of FOXO3a, which is required in the nucleus to maintain dormancy of the primordial follicles. These findings demonstrate that melatonin attenuates cisplatin-induced follicle loss by preventing the phosphorylation of PTEN/AKT/FOXO3a pathway members; thus, melatonin is a potential therapeutic agent for ovarian protection and fertility preservation during chemotherapy in female cancer patients." |
Sequence & Structure:
MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEDDDEDDEDGGGRASSAMVIGGGVSSTLGSGLLLEDSAMLLAPGGQDLGSGPASAAGALSGGTPTQLQPQQPLPQPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQAAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPILASTELDDVQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDLLDNIALPPSQPSPPGGLMQRGSSFPYTAKSSGLGSPTGSFNSTVFGPSSLNSLRQSPMQTIQENRPATFSSVSHYGNQTLQDLLASDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNVMLRNDPMMSFAAQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSDSSSLGSAKHQQQSPASQSMQTLSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
