| Id: | acc1195 |
| Group: | 2sens |
| Protein: | CREB |
| Gene Symbol: | Creb1 |
| Protein Id: | Q01147 |
| Protein Name: | CREB1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser133 |
| Site Sequence: | LNDLSSDAPGVPRIEEEKSEE |
| Disease Category: | Cancer |
| Disease: | Hepatocellular Carcinoma |
| Disease Subtype: | |
| Disease Cellline: | Hca-F |
| Disease Info: | |
| Drug: | Cav-1 |
| Drug Info: | - |
| Effect: | modulate |
| Effect Info: | "Cav-1 activates the MAPK signaling pathway and promotes the phosphorylation of transcription factors CREB, Sp1, HNF4A, and c-Myc, thereby inducing the transcription of Pofut1. The expression of Pofut1 promotes the invasion and metastasis of tumor cells." |
| Note: | retraction |
| Score: | 3.0 |
| Pubmed(PMID): | 31209283 |
| Sentence Index: | 31209283_5-6 |
| Sentence: | "Cav-1 activated MAPK signaling and promoted phosphorylation of the transcription factors CREB, Sp1, HNF4A and c-Myc, which bound to the Pofut1 promoter region to induce its transcription. As Notch signaling receptors can be modified with O-fucose by Pofut1, we further showed that Cav-1-induced upregulation of Pofut1 expression activated the Notch pathway and thus enhanced invasion and metastasis by mouse HCC cells in vitro and in vivo." |
Sequence & Structure:
MTMESGADNQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 133 | D | Type 2 diabetes | Phosphorylation | 34193609 |
| S | 133 | N | Heart failure | Phosphorylation | 17616745 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
