| Id: | acc1249 |
| Group: | 2sens |
| Protein: | Arix |
| Gene Symbol: | PHOX2A |
| Protein Id: | O14813 |
| Protein Name: | PHX2A_HUMAN |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cancer |
| Disease: | Neuroblastoma |
| Disease Subtype: | |
| Disease Cellline: | SH-SY5Y |
| Disease Info: | |
| Drug: | PD98059 |
| Drug Info: | PD98059 is a selective and cell-permeable inhibitor of MAP kinase kinase (MEK) that blocks the activation of mitogen-activated protein (MAP) kinase by inhibiting MEK1 and MEK2 phosphorylation. |
| Effect: | modulate |
| Effect Info: | MEK1 inhibitors (such as UO126 and PD98059) can reduce the phosphorylation level of Arix/Phox2a. |
| Note: | no tumor effct |
| Score: | 3.0 |
| Pubmed(PMID): | 16156742 |
| Sentence Index: | 16156742_6-7 |
| Sentence: | "Treatment of neuroblastoma cultures with PD98059 increases the interaction of Arix with DBH and NET genes, but not the TH gene. Together, these results suggest that phosphorylation of Arix by ERK1/2 inhibits its ability to interact with target genes, and that both specificity of expression and modulation by external stimuli are monitored through the same transcription factor." |
Sequence & Structure:
MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPGLASPRLSPSPLPVALGSGPGPGPGPQPLKGALWAGVAGGGGGGPGAGAAELLKAWQPAESGPGPFSGVLSSFHRKPGPALKTNLF
No data.
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
