| Id: | acc1351 |
| Group: | 2sens |
| Protein: | ATF-2 |
| Gene Symbol: | Atf2 |
| Protein Id: | P16951 |
| Protein Name: | ATF2_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr71 |
| Site Sequence: | EEVGLFNELASPFENEFKKAS |
| Disease Category: | Cancer |
| Disease: | Melanoma |
| Disease Subtype: | |
| Disease Cellline: | B16 |
| Disease Info: | |
| Drug: | Taxol |
| Drug Info: | "Taxol (paclitaxel) is a chemotherapeutic agent that stabilizes microtubules to inhibit cancer cell division, primarily used in the treatment of ovarian, breast, and lung cancers." |
| Effect: | inhibit |
| Effect Info: | Retinoic acid reduces ATF-2 phosphorylation and sensitizes melanoma cells to paclitaxel-mediated growth inhibition. |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 18269766 |
| Sentence Index: | 18269766_4-5 |
| Sentence: | "In addition, the melanoma cells had a much higher amount of phosphorylated (active) ATF-2 than the immortalized melanocytes. In the course of determining how retinoic acid (RA) stimulates activating protein-1 (AP-1) activity in B16 melanoma, we discovered that this retinoid decreased the phosphorylation of ATF-2." |
Sequence & Structure:
MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPPSQAQPSGS
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
