Id: acc1428
Group: 2sens
Protein: IRS1
Gene Symbol: IRS1
Protein Id: P35568
Protein Name: IRS1_HUMAN
PTM: phosphorylation
Site: Ser1101
Site Sequence: PQGCRRRHSSETFSSTPSATR
Disease Category: Cancer
Disease: Lung Cancer
Disease Subtype: NSCLC
Disease Cellline: A549
Disease Info:
Drug: ZNF323A OV
Drug Info: -
Effect: modulate
Effect Info: The drug causes protein phosphorylation and promotes tumor autophagy.
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 32576196
Sentence Index:
Sentence:

Sequence & Structure:

MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
IRS1-Ser1101
Cancer Intensity
BRCA -1.279
COAD 0.625
HGSC 1.291
ccRCC
GBM
HNSC 0.786
LUAD 0.106
LUSC 0.608
non_ccRCC
PDAC -1.182
UCEC -0.955

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 1101 U Diabetes mellitus Phosphorylation 17709744

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM
Protein Gene PTM Position Modified sequence Cell Drug pEC50 Regulation Experiment
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR HeLa Curcumin 4.3872 down
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR K562 Paclitaxel 6.7803 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 Refametinib 9.9339 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 Staursporin 8.5271 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 Tideglusib 7.0267 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR BT-474 Lapatinib 6.7559 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR BT-474 Trastuzumab -1.3664 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR HeLa A485 11.1331 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR HeLa A485 6.3985 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR HeLa CUDC101 5.7343 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR HeLa Romidepsin 12.6447 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR HeLa SAHA 6.5242 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR K562 Cytarabine 8.2629 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR A549 Pictilisib 8.7629 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR MDA-MB-175 Lapatinib 6.6835 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR MDA-MB-175 Pertuzumab -3.2528 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR MDA-MB-175 Trastuzumab -4.7413 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR PC-9 AZD4547 5.2544 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR PC-9 Gefitinib 1.5229 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR PC-9 GeftinibAZD4547-1to80 8.0131 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR PC-9 GeftinibAZD4547-1to80 7.7653 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR PC-9 Lapatinib 5.2545 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR PC-9 LapatinibAZD4547 5.2605 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR PC-9 LapatinibAZD4547 5.1432 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR Ramos Rituximab 2.0339 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR Ramos Rituximab -2.2156 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A459 SelumetinibMK2206-3to1 4.9357 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A431 Afatinib 7.7621 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A431 Dasatinib 6.5822 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A431 Dasatinib 12.7548 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A431 Imatinib 12.5659 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A459 MK2206 6.2632 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A459 MK2206 5.7767 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR A459 MK2206 4.7556 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR A459 Selumetinib 8.2421 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A459 Selumetinib 8.0195 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR A459 Selumetinib 7.0015 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A459 Selumetinib 1.5229 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A459 SelumetinibMK2206-1to2 6.3989 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A431 Afatinib 9.2553 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 AZD8055 7.7619 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 Dactolisib 15 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 Dasatinib 7.2286 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR A549 Dasatinib 7.0182 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 Dasatinib 6.2616 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 MK2206 6.2973 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 Nintedanib 10.9095 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR A549 Nintedanib 6.7567 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 PD325901 9.0184 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 PD325901 5.7949 -
P35568 IRS1 P Ser1101 RHSS(ph)ETFSSTPSATR A549 PD325901 5.0924 -
P35568 IRS1 P Ser1101 HSS(ph)ETFSSTPSATR A549 Pictilisib 10.9818 -

pEC50 Note: pEC50 is the negative logarithm of EC50 (half-maximal effective concentration, dosage unit Mol), calculated as pEC50 = -log10(EC50), which quantifies the potency of a drug or compound.

Function score:

source: funscoR

No data.

Cross Links: