PMADS

Id:	acc1447
Group:	2sens
Protein:	p53
Gene Symbol:	TP53
Protein Id:	P04637
Protein Name:	P53_HUMAN
PTM:	phosphorylation
Site:	Ser15
Site Sequence:	SDPSVEPPLSQETFSDLWKLL
Disease Category:	Cancer
Disease:	Melanoma
Disease Subtype:
Disease Cellline:	A375
Disease Info:
Drug:	TRAIL
Drug Info:	"TRAIL (TNF-related apoptosis-inducing ligand), a member of the tumor necrosis factor (TNF) superfamily, selectively induces apoptosis in tumor cells while exhibiting minimal toxicity to normal cells, primarily through binding to death receptors DR4 and DR5."
Effect:	inhibit
Effect Info:	The drug induces ROS-dependent apoptosis by upregulating protein phosphorylation.
Note:
Score:	5.0
Pubmed(PMID):	25277183
Sentence Index:	25277183_4-5
Sentence:	"Herein, we reported that 3,3'-diselenodipropionic acid (DSeA), a Selenocysteine derivative, could synergistically enhance the growth inhibitory effect of TRAIL on A375 melanoma cells though induction of ROS-dependent apoptosis with involvement of PTEN-mediated Akt inactivation and DNA damage-mediated p53 phosphorylation, which subsequently activated mitochondrial and death receptor apoptotic pathways. Moreover, silencing of p53 down-regulated the expression levels of p53-inducible genes, and effectively blocked the cell apoptosis."

Sequence & Structure:

MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target	Drug name	MOA	Phase	Status	Disease	Source
TP53	EPRENETAPOPT	Cellular tumor antigen p53 stabiliser	3	Completed	myelodysplastic syndrome	ClinicalTrials
TP53	IDASANUTLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	3	Terminated	acute myeloid leukemia	ClinicalTrials
TP53	CENERSEN SODIUM	p53 mRNA antisense inhibitor	2	Terminated	chronic lymphocytic leukemia	ClinicalTrials
TP53	CENERSEN	p53 mRNA antisense inhibitor	2	Completed	acute myeloid leukemia	ClinicalTrials
TP53	CENERSEN	p53 mRNA antisense inhibitor	2	Withdrawn	acute myeloid leukemia	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	essential thrombocythemia	ClinicalTrials
TP53	SIREMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	neoplasm	ClinicalTrials
TP53	IDASANUTLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	neoplasm	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Terminated	small cell lung carcinoma	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Active, not recruiting	polycythemia vera	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	polycythemia vera	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	primary myelofibrosis	ClinicalTrials
TP53	IDASANUTLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Terminated	polycythemia vera	ClinicalTrials
TP53	CONTUSUGENE LADENOVEC	Cellular tumor antigen p53 exogenous gene	2	Unknown status	non-small cell lung carcinoma	ClinicalTrials
TP53	APG115	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	lymphoid leukemia	ClinicalTrials
TP53	CONTUSUGENE LADENOVEC	Cellular tumor antigen p53 exogenous gene	2	Terminated	head and neck malignant neoplasia	ClinicalTrials
TP53	CONTUSUGENE LADENOVEC	Cellular tumor antigen p53 exogenous gene	2	Unknown status	head and neck malignant neoplasia	ClinicalTrials ClinicalTrials
TP53	EPRENETAPOPT	Cellular tumor antigen p53 stabiliser	2	Withdrawn	Mantle cell lymphoma	ClinicalTrials
TP53	TEPRASIRAN	p53 mRNA RNAi inhibitor	2	Completed	Acute kidney injury	ClinicalTrials
TP53	EPRENETAPOPT	Cellular tumor antigen p53 stabiliser	2	Completed	ovarian cancer	ClinicalTrials
TP53	CONTUSUGENE LADENOVEC	Cellular tumor antigen p53 exogenous gene	2	Completed	breast cancer	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	endometrial cancer	ClinicalTrials
TP53	CENERSEN	p53 mRNA antisense inhibitor	1	Terminated	myelodysplastic syndrome	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	1	Active, not recruiting	acute myeloid leukemia	ClinicalTrials ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	1	Completed	acute myeloid leukemia	ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets

Small molecule

Antibody

PROTAC

Other modalities

Approved Drug

Advanced Clinical

Phase 1 Clinical

Structure with Ligand

High-Quality Ligand

High-Quality Pocket

Med-Quality Pocket

Druggable Family

Approved Drug

Advanced Clinical

Phase 1 Clinical

UniProt loc high conf

GO CC high conf

UniProt loc med conf

UniProt SigP or TMHMM

GO CC med conf

Human Protein Atlas loc

Approved Drug

Advanced Clinical

Phase 1 Clinical

Literature

UniProt Ubiquitination

Database Ubiquitination

Half-life Data

Small Molecule Binder

Approved Drug

Advanced Clinical

Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

TP53-Ser314
Cancer	Intensity
BRCA
COAD	0.707
HGSC
ccRCC
GBM
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53-Ser315
Cancer	Intensity
BRCA
COAD	-1.105
HGSC	0.842
ccRCC	0.263
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53-Thr150
Cancer	Intensity
BRCA
COAD
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser101
Cancer	Intensity
BRCA
COAD	0.422
HGSC	-1.142
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.72

TP53BP1-Ser1024
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.707
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1030
Cancer	Intensity
BRCA
COAD	-1.646
HGSC
ccRCC	0.325
GBM	1.443
HNSC	-0.173
LUAD	0.213
LUSC
non_ccRCC
PDAC
UCEC	-0.162

TP53BP1-Ser1033
Cancer	Intensity
BRCA	1.211
COAD	-0.937
HGSC	2.312
ccRCC	-0.583
GBM	-0.187
HNSC	-0.362
LUAD	-0.923
LUSC	-0.762
non_ccRCC	0.539
PDAC	-0.285
UCEC	-0.023

TP53BP1-Ser1039
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC	0.707
non_ccRCC
PDAC
UCEC	-0.707

TP53BP1-Ser1072
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	1.378
ccRCC	0.381
GBM	0.572
HNSC	-1.199
LUAD	-1.107
LUSC
non_ccRCC
PDAC
UCEC	0.682

TP53BP1-Ser1073
Cancer	Intensity
BRCA	0.669
COAD	-1.359
HGSC	1.711
ccRCC	0.013
GBM	-1.1
HNSC	-0.352
LUAD	-0.325
LUSC	-0.93
non_ccRCC	1.416
PDAC	0.594
UCEC	-0.338

TP53BP1-Ser108
Cancer	Intensity
BRCA
COAD
HGSC	-1.494
ccRCC	0.385
GBM
HNSC	0.592
LUAD	0.518
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1091
Cancer	Intensity
BRCA	-0.162
COAD
HGSC
ccRCC	0.068
GBM
HNSC	-0.502
LUAD	-1.047
LUSC
non_ccRCC	1.887
PDAC
UCEC	-0.245

TP53BP1-Ser1099
Cancer	Intensity
BRCA	-0.026
COAD	-0.791
HGSC	2.796
ccRCC	-0.009
GBM	-0.536
HNSC	-0.528
LUAD	-0.656
LUSC	-0.569
non_ccRCC	0.469
PDAC	-0.136
UCEC	-0.016

TP53BP1-Ser110
Cancer	Intensity
BRCA	1.172
COAD
HGSC	-1.547
ccRCC
GBM
HNSC
LUAD	-0.219
LUSC	0.235
non_ccRCC
PDAC
UCEC	0.359

TP53BP1-Ser1106
Cancer	Intensity
BRCA	-0.4
COAD	-1.116
HGSC	-0.312
ccRCC	0.547
GBM	-0.568
HNSC	-0.441
LUAD	-0.968
LUSC	-0.471
non_ccRCC	2.364
PDAC	0.704
UCEC	0.661

TP53BP1-Ser1109
Cancer	Intensity
BRCA
COAD	0.039
HGSC	-2.593
ccRCC	0.274
GBM	0.059
HNSC	0.319
LUAD
LUSC	0.217
non_ccRCC	0.798
PDAC	0.535
UCEC	0.352

TP53BP1-Ser1118
Cancer	Intensity
BRCA
COAD	-0.141
HGSC	-1.543
ccRCC	-1.102
GBM	0.247
HNSC	1.264
LUAD	-0.614
LUSC	0.464
non_ccRCC	-0.502
PDAC	1.68
UCEC	0.245

TP53BP1-Ser1119
Cancer	Intensity
BRCA
COAD	-0.086
HGSC	-2.266
ccRCC	0.103
GBM	0.966
HNSC	0.693
LUAD	0.411
LUSC
non_ccRCC
PDAC	-0.265
UCEC	0.442

TP53BP1-Ser1221
Cancer	Intensity
BRCA
COAD	0.707
HGSC
ccRCC
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1224
Cancer	Intensity
BRCA
COAD	0.707
HGSC
ccRCC
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser124
Cancer	Intensity
BRCA
COAD	0.494
HGSC	-1.151
ccRCC
GBM
HNSC
LUAD	0.657
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1293
Cancer	Intensity
BRCA
COAD	-1.016
HGSC	1.342
ccRCC
GBM	0.076
HNSC	-0.402
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1295
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1300
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1301
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser132
Cancer	Intensity
BRCA	0.744
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	-1.235
LUSC	0.878
non_ccRCC
PDAC
UCEC	-0.387

TP53BP1-Ser1322
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1325
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1327
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1347
Cancer	Intensity
BRCA
COAD
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.707

TP53BP1-Ser1367
Cancer	Intensity
BRCA
COAD	-0.307
HGSC	1.914
ccRCC	-0.145
GBM
HNSC	-0.147
LUAD	-1.067
LUSC
non_ccRCC
PDAC	-0.247
UCEC

TP53BP1-Ser1431
Cancer	Intensity
BRCA	0.246
COAD	0.043
HGSC	-2.497
ccRCC	0.213
GBM	0.159
HNSC	-0.014
LUAD	-0.134
LUSC	-0.797
non_ccRCC	1.417
PDAC	0.55
UCEC	0.816

TP53BP1-Ser1435
Cancer	Intensity
BRCA	-0.113
COAD	-0.034
HGSC	-2.759
ccRCC	0.293
GBM	0.398
HNSC	-0.001
LUAD	-0.361
LUSC	0.187
non_ccRCC	0.999
PDAC	0.705
UCEC	0.686

TP53BP1-Ser1467
Cancer	Intensity
BRCA
COAD	0.052
HGSC	-1.961
ccRCC	0.335
GBM
HNSC	0.235
LUAD	0.458
LUSC
non_ccRCC
PDAC
UCEC	0.88

TP53BP1-Ser1479
Cancer	Intensity
BRCA	1.04
COAD
HGSC
ccRCC	-0.431
GBM
HNSC	-0.965
LUAD	-0.754
LUSC
non_ccRCC
PDAC
UCEC	1.11

TP53BP1-Ser1485
Cancer	Intensity
BRCA
COAD
HGSC	-1.145
ccRCC
GBM
HNSC	0.704
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.441

TP53BP1-Ser1486
Cancer	Intensity
BRCA
COAD	-0.176
HGSC	-1.675
ccRCC
GBM	0.676
HNSC	0.499
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.676

TP53BP1-Ser1553
Cancer	Intensity
BRCA	-0.399
COAD	-0.09
HGSC	-1.597
ccRCC	-0.186
GBM	2.062
HNSC	-0.731
LUAD	0.544
LUSC
non_ccRCC	-0.011
PDAC
UCEC	0.406

TP53BP1-Ser1570
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC
UCEC	-0.707

TP53BP1-Ser1623
Cancer	Intensity
BRCA	0.109
COAD	0.706
HGSC	-0.313
ccRCC	0.633
GBM	-0.649
HNSC	-0.116
LUAD	-0.594
LUSC	-2.106
non_ccRCC
PDAC	1.333
UCEC	0.996

TP53BP1-Ser1636
Cancer	Intensity
BRCA	2.069
COAD
HGSC
ccRCC
GBM	-0.803
HNSC	0.499
LUAD	-0.343
LUSC	-0.484
non_ccRCC
PDAC	-0.596
UCEC	-0.341

TP53BP1-Ser1639
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.707

TP53BP1-Ser1640
Cancer	Intensity
BRCA
COAD	0.48
HGSC	-2.197
ccRCC
GBM	0.518
HNSC	-0.103
LUAD
LUSC	0.197
non_ccRCC	0.631
PDAC	0.473
UCEC

TP53BP1-Ser1647
Cancer	Intensity
BRCA
COAD	-0.281
HGSC	1.11
ccRCC	-0.829
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1648
Cancer	Intensity
BRCA
COAD
HGSC	1.462
ccRCC	-0.179
GBM	-0.704
HNSC	-0.579
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1649
Cancer	Intensity
BRCA
COAD	-0.509
HGSC	1.152
ccRCC
GBM	-0.643
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1650
Cancer	Intensity
BRCA
COAD	-0.045
HGSC	1.661
ccRCC
GBM	-0.557
HNSC	-0.1
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.959

TP53BP1-Ser1670
Cancer	Intensity
BRCA	-1.256
COAD
HGSC
ccRCC
GBM	1.05
HNSC	0.489
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.283

TP53BP1-Ser1678
Cancer	Intensity
BRCA	-0.443
COAD
HGSC
ccRCC	0.603
GBM
HNSC	0.93
LUAD	-1.54
LUSC	0.45
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1683
Cancer	Intensity
BRCA	-0.772
COAD	0.322
HGSC	1.65
ccRCC	-0.051
GBM	-0.095
HNSC	-0.488
LUAD	-1.952
LUSC	-0.351
non_ccRCC	1.276
PDAC	-0.344
UCEC	0.805

TP53BP1-Ser1691
Cancer	Intensity
BRCA
COAD
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser1706
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1710
Cancer	Intensity
BRCA	-1.394
COAD	0.841
HGSC	-0.038
ccRCC
GBM
HNSC	0.59
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1763
Cancer	Intensity
BRCA
COAD	-0.438
HGSC	-0.706
ccRCC
GBM
HNSC	1.144
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1764
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1976
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser207
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-1.152
GBM
HNSC	0.647
LUAD	0.505
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser213
Cancer	Intensity
BRCA
COAD
HGSC	-1.494
ccRCC
GBM	0.482
HNSC
LUAD
LUSC	0.615
non_ccRCC
PDAC
UCEC	0.398

TP53BP1-Ser227
Cancer	Intensity
BRCA	-0.559
COAD	1.032
HGSC	-2.558
ccRCC	0.347
GBM	0.449
HNSC	-0.102
LUAD	-0.028
LUSC	0.4
non_ccRCC	-0.468
PDAC	1.106
UCEC	0.381

TP53BP1-Ser264
Cancer	Intensity
BRCA
COAD
HGSC	0.99
ccRCC	-0.182
GBM
HNSC	-0.921
LUAD	-0.976
LUSC
non_ccRCC
PDAC
UCEC	1.09

TP53BP1-Ser270
Cancer	Intensity
BRCA	-1.282
COAD	-0.547
HGSC	0.337
ccRCC	0.598
GBM	-1.076
HNSC	-0.407
LUAD	-0.065
LUSC	0.122
non_ccRCC	2.428
PDAC	-0.468
UCEC	0.359

TP53BP1-Ser285
Cancer	Intensity
BRCA	1.685
COAD
HGSC
ccRCC	-0.745
GBM	1.526
HNSC	-0.932
LUAD	-0.956
LUSC	-0.513
non_ccRCC	0.35
PDAC	-0.309
UCEC	-0.105

TP53BP1-Ser292
Cancer	Intensity
BRCA
COAD	-1.068
HGSC
ccRCC	0.155
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC	0.914
UCEC

TP53BP1-Ser299
Cancer	Intensity
BRCA	0.87
COAD	-0.078
HGSC	-2.675
ccRCC	-0.093
GBM	-0.102
HNSC	0.366
LUAD	0.294
LUSC
non_ccRCC	0.809
PDAC	0.331
UCEC	0.278

TP53BP1-Ser306
Cancer	Intensity
BRCA	0.988
COAD
HGSC	-2.119
ccRCC	-0.082
GBM	0.471
HNSC	0.168
LUAD
LUSC
non_ccRCC
PDAC	0.523
UCEC	0.051

TP53BP1-Ser315
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	-0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser320
Cancer	Intensity
BRCA
COAD
HGSC	-1.367
ccRCC
GBM
HNSC
LUAD	0.823
LUSC	-0.12
non_ccRCC
PDAC
UCEC	0.664

TP53BP1-Ser321
Cancer	Intensity
BRCA
COAD	0.049
HGSC	-1.635
ccRCC
GBM
HNSC
LUAD	1.072
LUSC	0.111
non_ccRCC
PDAC
UCEC	0.404

TP53BP1-Ser328
Cancer	Intensity
BRCA
COAD	0.516
HGSC	-1.499
ccRCC
GBM
HNSC
LUAD	0.462
LUSC
non_ccRCC
PDAC
UCEC	0.521

TP53BP1-Ser338
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser354
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC	-0.707
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser364
Cancer	Intensity
BRCA
COAD	0.056
HGSC	-1.97
ccRCC	0.135
GBM
HNSC	0.748
LUAD	0.568
LUSC
non_ccRCC
PDAC
UCEC	0.463

TP53BP1-Ser365
Cancer	Intensity
BRCA
COAD	0.194
HGSC	-2.17
ccRCC	0.331
GBM	0.514
HNSC	0.459
LUAD	-0.134
LUSC
non_ccRCC
PDAC
UCEC	0.807

TP53BP1-Ser371
Cancer	Intensity
BRCA
COAD	0.363
HGSC	-2.39
ccRCC	0.224
GBM	0.432
HNSC	0.282
LUAD	0.45
LUSC	0.787
non_ccRCC	-1.185
PDAC	0.322
UCEC	0.716

TP53BP1-Ser384
Cancer	Intensity
BRCA
COAD	-0.738
HGSC	-1.53
ccRCC	0.308
GBM	0.046
HNSC	1.09
LUAD	-0.451
LUSC
non_ccRCC
PDAC
UCEC	1.275

TP53BP1-Ser385
Cancer	Intensity
BRCA
COAD	-0.386
HGSC	-0.687
ccRCC	-1.022
GBM	0.177
HNSC	1.595
LUAD
LUSC
non_ccRCC	-1.225
PDAC	0.946
UCEC	0.602

TP53BP1-Ser400
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC	0.404
LUAD	-1.139
LUSC
non_ccRCC
PDAC
UCEC	0.735

TP53BP1-Ser403
Cancer	Intensity
BRCA	-0.985
COAD	-0.068
HGSC	1.876
ccRCC	-0.131
GBM	-0.285
HNSC	0.06
LUAD	-1.371
LUSC	-0.905
non_ccRCC	1.623
PDAC	0.257
UCEC	-0.07

TP53BP1-Ser498
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.707
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser505
Cancer	Intensity
BRCA	-0.037
COAD	0.014
HGSC	-2.9
ccRCC	0.331
GBM	0.067
HNSC	0.367
LUAD	0.392
LUSC	0.005
non_ccRCC	0.902
PDAC	0.485
UCEC	0.375

TP53BP1-Ser512
Cancer	Intensity
BRCA	1.485
COAD	0.489
HGSC	-0.63
ccRCC	0.023
GBM	0.487
HNSC	1.573
LUAD	0.259
LUSC	-0.106
non_ccRCC	-1.184
PDAC	-0.978
UCEC	-1.417

TP53BP1-Ser517
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser523
Cancer	Intensity
BRCA
COAD
HGSC	-0.69
ccRCC	0.759
GBM
HNSC	0.019
LUAD	-1.257
LUSC
non_ccRCC
PDAC
UCEC	1.17

TP53BP1-Ser525
Cancer	Intensity
BRCA
COAD	0.506
HGSC	0.654
ccRCC	0.077
GBM	-2.217
HNSC	0.145
LUAD	0.301
LUSC
non_ccRCC
PDAC
UCEC	0.535

TP53BP1-Ser528
Cancer	Intensity
BRCA
COAD	-0.171
HGSC	-1.639
ccRCC	-0.136
GBM	0.779
HNSC	-0.185
LUAD	-0.644
LUSC	2.069
non_ccRCC	0.763
PDAC	-0.411
UCEC	-0.425

TP53BP1-Ser530
Cancer	Intensity
BRCA	-0.036
COAD	0.178
HGSC	-1.733
ccRCC	0.596
GBM	0.017
HNSC	0.345
LUAD	-1.451
LUSC	-0.164
non_ccRCC	2.072
PDAC	0.245
UCEC	-0.069

TP53BP1-Ser535
Cancer	Intensity
BRCA
COAD
HGSC	1.018
ccRCC
GBM	-0.981
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.037

TP53BP1-Ser537
Cancer	Intensity
BRCA
COAD
HGSC	0.707
ccRCC
GBM	-0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser557
Cancer	Intensity
BRCA	0.648
COAD	-0.154
HGSC	-2.781
ccRCC	0.241
GBM	-0.252
HNSC	0.948
LUAD	-0.18
LUSC	0.094
non_ccRCC	0.681
PDAC	0.458
UCEC	0.296

TP53BP1-Ser571
Cancer	Intensity
BRCA	-0.576
COAD	1.754
HGSC	-0.006
ccRCC	-0.236
GBM	-1.184
HNSC	0.071
LUAD	-0.992
LUSC	-0.507
non_ccRCC	0.32
PDAC	1.875
UCEC	-0.519

TP53BP1-Ser585
Cancer	Intensity
BRCA	0.535
COAD	-1.562
HGSC	-1.703
ccRCC	0.742
GBM	-0.353
HNSC	-0.287
LUAD	-0.472
LUSC	0.187
non_ccRCC	1.433
PDAC	1.064
UCEC	0.415

TP53BP1-Ser603
Cancer	Intensity
BRCA
COAD
HGSC	1.323
ccRCC	-0.58
GBM	-0.26
HNSC
LUAD
LUSC	-1.028
non_ccRCC	-0.475
PDAC	1.521
UCEC	-0.501

TP53BP1-Ser635
Cancer	Intensity
BRCA
COAD
HGSC	-1.368
ccRCC	-0.486
GBM	1.411
HNSC	0.686
LUAD
LUSC
non_ccRCC	0.327
PDAC
UCEC	-0.57

TP53BP1-Ser640
Cancer	Intensity
BRCA	-0.305
COAD
HGSC	-1.283
ccRCC
GBM
HNSC
LUAD	0.827
LUSC
non_ccRCC
PDAC
UCEC	0.76

TP53BP1-Ser644
Cancer	Intensity
BRCA	-1.334
COAD	0.02
HGSC	-1.641
ccRCC	-0.056
GBM	0.081
HNSC	0.04
LUAD	0.851
LUSC
non_ccRCC
PDAC	1.617
UCEC	0.421

TP53BP1-Ser645
Cancer	Intensity
BRCA	-1.351
COAD	0.124
HGSC	-1.73
ccRCC	-0.073
GBM	0.456
HNSC	0.134
LUAD	0.53
LUSC
non_ccRCC
PDAC	1.6
UCEC	0.31

TP53BP1-Ser664
Cancer	Intensity
BRCA	-1.928
COAD
HGSC
ccRCC	0.231
GBM	-1.015
HNSC	0.184
LUAD	0.689
LUSC
non_ccRCC	0.698
PDAC	0.045
UCEC	1.095

TP53BP1-Ser665
Cancer	Intensity
BRCA	-1.928
COAD
HGSC
ccRCC	0.231
GBM	-1.015
HNSC	0.184
LUAD	0.689
LUSC
non_ccRCC	0.698
PDAC	0.045
UCEC	1.095

TP53BP1-Ser667
Cancer	Intensity
BRCA	-1.933
COAD
HGSC
ccRCC	0.323
GBM	-1.024
HNSC	0.17
LUAD	0.673
LUSC
non_ccRCC	0.682
PDAC	0.032
UCEC	1.078

TP53BP1-Ser679
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser68
Cancer	Intensity
BRCA	0.987
COAD	-2.012
HGSC	-1.715
ccRCC	0.437
GBM	0.453
HNSC	-0.118
LUAD	-0.346
LUSC	0.676
non_ccRCC	0.387
PDAC	0.38
UCEC	0.871

TP53BP1-Ser697
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC	-0.055
LUAD	-1.182
LUSC	1.264
non_ccRCC	-0.027
PDAC
UCEC

TP53BP1-Ser718
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.707
GBM
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser726
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.447
GBM	1.442
HNSC	0.504
LUAD	-0.336
LUSC
non_ccRCC
PDAC
UCEC	-1.163

TP53BP1-Ser729
Cancer	Intensity
BRCA
COAD	-0.13
HGSC	-2.257
ccRCC	0.179
GBM	-0.219
HNSC	0.587
LUAD	0.141
LUSC	0.884
non_ccRCC
PDAC
UCEC	0.814

TP53BP1-Ser732
Cancer	Intensity
BRCA	-0.208
COAD	0.142
HGSC	-2.711
ccRCC	0.191
GBM	-0.037
HNSC	0.05
LUAD	0.206
LUSC	0.05
non_ccRCC	0.327
PDAC	1.45
UCEC	0.541

TP53BP1-Ser770
Cancer	Intensity
BRCA	0.423
COAD
HGSC
ccRCC	-0.747
GBM
HNSC
LUAD	-0.37
LUSC
non_ccRCC	-0.983
PDAC	1.775
UCEC	-0.098

TP53BP1-Ser776
Cancer	Intensity
BRCA	0.271
COAD	0.765
HGSC	-2.79
ccRCC	0.158
GBM	-0.191
HNSC	-0.218
LUAD	0.138
LUSC	-0.044
non_ccRCC	0.472
PDAC	1.01
UCEC	0.428

TP53BP1-Ser787
Cancer	Intensity
BRCA
COAD	-0.707
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser789
Cancer	Intensity
BRCA
COAD	-0.416
HGSC	-0.725
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	1.141

TP53BP1-Ser791
Cancer	Intensity
BRCA
COAD	-0.396
HGSC	-0.758
ccRCC	-0.504
GBM	-0.548
HNSC
LUAD	-0.418
LUSC
non_ccRCC	0.571
PDAC
UCEC	2.053

TP53BP1-Ser814
Cancer	Intensity
BRCA	1.193
COAD	0.263
HGSC	-1.342
ccRCC	0.174
GBM	0.512
HNSC	-0.612
LUAD	0.029
LUSC	-1.749
non_ccRCC	1.038
PDAC	1.19
UCEC	-0.696

TP53BP1-Ser83
Cancer	Intensity
BRCA	-1.09
COAD
HGSC	0.998
ccRCC
GBM	0.683
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.591

TP53BP1-Ser835
Cancer	Intensity
BRCA
COAD	0.165
HGSC	-2.217
ccRCC	0.396
GBM	0.155
HNSC	0.71
LUAD	0.221
LUSC
non_ccRCC
PDAC
UCEC	0.57

TP53BP1-Ser836
Cancer	Intensity
BRCA	-0.736
COAD	0.068
HGSC	-2.686
ccRCC	0.772
GBM	0.974
HNSC	0.564
LUAD	0.065
LUSC	0.48
non_ccRCC	0.333
PDAC	-0.008
UCEC	0.173

TP53BP1-Ser839
Cancer	Intensity
BRCA	-0.583
COAD	-0.188
HGSC	-2.68
ccRCC	1.035
GBM	0.581
HNSC	0.651
LUAD	0.173
LUSC	0.34
non_ccRCC	0.331
PDAC	-0.215
UCEC	0.556

TP53BP1-Ser865
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.191
GBM	0.78
HNSC	0.126
LUAD	-1.599
LUSC
non_ccRCC
PDAC
UCEC	0.885

TP53BP1-Ser867
Cancer	Intensity
BRCA	-0.274
COAD	-0.662
HGSC	-2.153
ccRCC	0.879
GBM	1.09
HNSC	0.043
LUAD	-0.521
LUSC	-0.128
non_ccRCC
PDAC	0.631
UCEC	1.096

TP53BP1-Ser872
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser980
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.791
HNSC	-1.124
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.333

TP53BP1-Thr1060
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	1.029
HNSC	-0.968
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.062

TP53BP1-Thr1061
Cancer	Intensity
BRCA
COAD	-0.269
HGSC	-0.937
ccRCC
GBM	1.254
HNSC	-0.884
LUAD	0.836
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1127
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1297
Cancer	Intensity
BRCA
COAD	-0.984
HGSC
ccRCC
GBM	1.016
HNSC	-0.032
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1324
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1377
Cancer	Intensity
BRCA
COAD
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Thr1547
Cancer	Intensity
BRCA
COAD
HGSC	-0.366
ccRCC	1.421
GBM
HNSC	-0.908
LUAD	-0.148
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1550
Cancer	Intensity
BRCA
COAD	0.132
HGSC
ccRCC	0.349
GBM	1.279
HNSC	-1.462
LUAD	-0.298
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1614
Cancer	Intensity
BRCA	-1.431
COAD	0.67
HGSC	-0.485
ccRCC	-0.788
GBM	2.021
HNSC	0.49
LUAD	0.36
LUSC	-1.166
non_ccRCC	-0.522
PDAC	0.109
UCEC	0.741

TP53BP1-Thr1643
Cancer	Intensity
BRCA	0.854
COAD	0.392
HGSC	-2.863
ccRCC	-0.177
GBM	0.33
HNSC	-0.216
LUAD	0.109
LUSC	0.262
non_ccRCC	0.662
PDAC	0.352
UCEC	0.295

TP53BP1-Thr1645
Cancer	Intensity
BRCA
COAD
HGSC	1.376
ccRCC	-0.165
GBM
HNSC	-0.191
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-1.021

TP53BP1-Thr1677
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.498
GBM
HNSC	0.653
LUAD	-1.151
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr210
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.953
GBM	-0.14
HNSC	1.405
LUAD	-0.312
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr307
Cancer	Intensity
BRCA	1.201
COAD
HGSC	-1.731
ccRCC	-0.4
GBM	0.405
HNSC
LUAD
LUSC
non_ccRCC
PDAC	0.485
UCEC	0.041

TP53BP1-Thr326
Cancer	Intensity
BRCA
COAD	0.178
HGSC	-1.077
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.899

TP53BP1-Thr339
Cancer	Intensity
BRCA
COAD
HGSC	-1.059
ccRCC
GBM
HNSC
LUAD	0.928
LUSC
non_ccRCC
PDAC
UCEC	0.131

TP53BP1-Thr362
Cancer	Intensity
BRCA
COAD	-0.707
HGSC
ccRCC	-1.347
GBM	0.87
HNSC	0.983
LUAD	-0.585
LUSC
non_ccRCC
PDAC
UCEC	0.787

TP53BP1-Thr387
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr514
Cancer	Intensity
BRCA
COAD	-1.013
HGSC
ccRCC
GBM
HNSC
LUAD	0.987
LUSC
non_ccRCC
PDAC
UCEC	0.026

TP53BP1-Thr524
Cancer	Intensity
BRCA
COAD
HGSC	-1.647
ccRCC	1.11
GBM	0.732
HNSC	0.067
LUAD	-0.62
LUSC
non_ccRCC
PDAC
UCEC	0.358

TP53BP1-Thr548
Cancer	Intensity
BRCA
COAD	-0.553
HGSC
ccRCC	-0.852
GBM	-1.152
HNSC	1.36
LUAD	-0.873
LUSC
non_ccRCC	1.18
PDAC	0.793
UCEC	0.098

TP53BP1-Thr553
Cancer	Intensity
BRCA	-0.948
COAD	-0.216
HGSC	2.491
ccRCC	-0.337
GBM	-0.276
HNSC	-0.039
LUAD	-0.644
LUSC
non_ccRCC
PDAC	0.332
UCEC	-0.364

TP53BP1-Thr596
Cancer	Intensity
BRCA	-1.264
COAD
HGSC	0.457
ccRCC	1.146
GBM	0.685
HNSC
LUAD	-1.219
LUSC	-0.575
non_ccRCC
PDAC
UCEC	0.77

TP53BP1-Thr598
Cancer	Intensity
BRCA
COAD	0.967
HGSC	0.99
ccRCC	0.746
GBM
HNSC
LUAD	-0.811
LUSC	-0.748
non_ccRCC
PDAC
UCEC	-1.145

TP53BP1-Thr625
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.906
GBM
HNSC	1.073
LUAD	-0.167
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr675
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.98
GBM	0.038
HNSC	-1.019
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr725
Cancer	Intensity
BRCA
COAD
HGSC	-1.498
ccRCC	0.475
GBM
HNSC	0.571
LUAD	0.452
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr860
Cancer	Intensity
BRCA
COAD
HGSC	1.149
ccRCC	-0.674
GBM
HNSC
LUAD
LUSC	-0.475
non_ccRCC
PDAC
UCEC

TP53BP1-Thr924
Cancer	Intensity
BRCA
COAD	0.049
HGSC	0.024
ccRCC	-1.129
GBM	1.767
HNSC	-0.772
LUAD	0.06
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr927
Cancer	Intensity
BRCA	0.42
COAD	-0.541
HGSC	1.114
ccRCC	-0.931
GBM	-1.874
HNSC	-1.072
LUAD	0.146
LUSC	0.75
non_ccRCC	1.404
PDAC	0.431
UCEC	0.152

TP53BP1-Tyr1610
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	1.408
GBM
HNSC	-0.86
LUAD	-0.528
LUSC
non_ccRCC
PDAC
UCEC	-0.02

TP53BP1-Tyr209
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.81
GBM	-0.249
HNSC	1.457
LUAD	-0.399
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Tyr527
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.475
GBM	0.028
HNSC	-0.762
LUAD	-1.128
LUSC
non_ccRCC
PDAC
UCEC	1.386

TP53BP1-Tyr817
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser302
Cancer	Intensity
BRCA	-1.124
COAD
HGSC
ccRCC	-0.566
GBM	-0.494
HNSC
LUAD	0.091
LUSC	0.149
non_ccRCC	0.005
PDAC	2.247
UCEC	-0.308

TP53BP2-Ser464
Cancer	Intensity
BRCA	0.527
COAD
HGSC	-2.253
ccRCC	-0.128
GBM
HNSC	0.072
LUAD	-0.304
LUSC	0.592
non_ccRCC	0.56
PDAC	0.933
UCEC

TP53BP2-Ser486
Cancer	Intensity
BRCA	1.276
COAD	0.133
HGSC	-0.092
ccRCC	0.2
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-1.518

TP53BP2-Ser487
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser562
Cancer	Intensity
BRCA
COAD	0.933
HGSC	-1.471
ccRCC
GBM
HNSC	0.591
LUAD	0.528
LUSC
non_ccRCC	-0.582
PDAC
UCEC

TP53BP2-Ser564
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser567
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC	0.707
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser575
Cancer	Intensity
BRCA
COAD
HGSC	-2.416
ccRCC
GBM	0.138
HNSC	0.568
LUAD	0.429
LUSC	0.408
non_ccRCC	-0.08
PDAC	0.404
UCEC	0.549

TP53BP2-Ser578
Cancer	Intensity
BRCA	1.05
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	-0.11
LUSC	-0.941
non_ccRCC
PDAC
UCEC

TP53BP2-Ser582
Cancer	Intensity
BRCA	-0.722
COAD
HGSC	2.745
ccRCC	-0.233
GBM	-0.056
HNSC	-0.16
LUAD	-0.307
LUSC	-0.097
non_ccRCC	-0.8
PDAC	-0.03
UCEC	-0.34

TP53BP2-Ser704
Cancer	Intensity
BRCA
COAD	0.146
HGSC	2.094
ccRCC	-0.259
GBM	-0.32
HNSC	0.017
LUAD
LUSC
non_ccRCC
PDAC	-0.921
UCEC	-0.758

TP53BP2-Ser720
Cancer	Intensity
BRCA	-1.018
COAD
HGSC	-1.714
ccRCC	0.383
GBM	-0.221
HNSC	0.064
LUAD	0.02
LUSC	0.356
non_ccRCC	2.135
PDAC	0.262
UCEC	-0.267

TP53BP2-Ser742
Cancer	Intensity
BRCA
COAD	-0.707
HGSC
ccRCC
GBM	0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser743
Cancer	Intensity
BRCA
COAD	-0.207
HGSC	0.596
ccRCC	-0.287
GBM	0.08
HNSC	-1.59
LUAD
LUSC	1.409
non_ccRCC
PDAC
UCEC

TP53BP2-Ser789
Cancer	Intensity
BRCA
COAD
HGSC	-1.164
ccRCC
GBM	0.336
HNSC	0.998
LUAD
LUSC	-0.714
non_ccRCC
PDAC	-0.697
UCEC	1.241

TP53BP2-Thr573
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-1.078
GBM
HNSC	1.195
LUAD	-0.506
LUSC
non_ccRCC
PDAC
UCEC	0.389

TP53BP2-Thr592
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.237
GBM
HNSC
LUAD	-0.622
LUSC
non_ccRCC	1.718
PDAC	-0.773
UCEC	-0.085

TP53BP2-Thr745
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.707
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC	0.707
UCEC

TP53I11-Ser14
Cancer	Intensity
BRCA	-1.268
COAD	0.477
HGSC	1.815
ccRCC	0.355
GBM	-0.192
HNSC	0.761
LUAD	-0.233
LUSC	0.795
non_ccRCC	-1.777
PDAC	-0.274
UCEC	-0.459

TP53I11-Ser20
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53I11-Ser45
Cancer	Intensity
BRCA	-0.707
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53I11-Thr16
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53INP2-Ser14
Cancer	Intensity
BRCA
COAD	1.043
HGSC
ccRCC
GBM
HNSC	0.065
LUAD
LUSC	0.25
non_ccRCC
PDAC
UCEC	-1.358

PTM-Disease Association:

source: PTMD

Residue	Position	State	Disease	Class	PMID
S	15	A	Breast cancer/tumor/carcinoma	Phosphorylation	23798621
S	15	D	Ataxia-telangiectasia	Phosphorylation	9733515
S	15	D	Brain cancer	Phosphorylation	23268709
S	15	D	Breast cancer/tumor/carcinoma	Phosphorylation	15958581
S	15	P	Prostate cancer/carcinoma/adenocarcinoma	Phosphorylation	23359208
S	15	U	Down syndrome	Phosphorylation	20696760
S	15	U	Hepatocellular carcinoma	Phosphorylation	22030623
S	15	U	Neuroblastoma	Phosphorylation	23824039
S	15	U	Colorectal cancer	Phosphorylation	25860929

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb