Id: acc1527
Group: 2sens
Protein: USP8
Gene Symbol: USP8
Protein Id: P40818
Protein Name: UBP8_HUMAN
PTM: phosphorylation
Site: Thr907
Site Sequence: NDHLDDFKAAEHAWQKHKQLN
Disease Category: Cancer
Disease: Breast Cancer
Disease Subtype:
Disease Cellline: MCF7
Disease Info:
Drug: NRG1 OV
Drug Info: -
Effect: modulate
Effect Info: "Akt promotes the stability of the deubiquitinase USP8 by phosphorylating the T907 site of USP8, leading to the ubiquitination and degradation of ErbB3. The overexpression of ErbB3 is often associated with increased malignancy, metastasis, and enhanced chemoresistance of tumors."
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 17210635
Sentence Index:
Sentence:

Sequence & Structure:

MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

USP8-Ser153
Cancer Intensity
BRCA -0.258
COAD 0.986
HGSC
ccRCC -0.5
GBM 1.26
HNSC 0.612
LUAD -1.399
LUSC -0.952
non_ccRCC -1.183
PDAC 1.197
UCEC 0.236
USP8-Ser378
Cancer Intensity
BRCA
COAD
HGSC
ccRCC -0.707
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC 0.707
USP8-Ser389
Cancer Intensity
BRCA 0.25
COAD
HGSC
ccRCC
GBM -1.338
HNSC -0.698
LUAD
LUSC
non_ccRCC 1.076
PDAC 0.709
UCEC
USP8-Ser392
Cancer Intensity
BRCA
COAD -0.942
HGSC -0.366
ccRCC 0.044
GBM -0.306
HNSC 1.875
LUAD 0.661
LUSC
non_ccRCC
PDAC
UCEC -0.965
USP8-Ser400
Cancer Intensity
BRCA
COAD -0.707
HGSC
ccRCC 0.707
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
USP8-Ser434
Cancer Intensity
BRCA -1.398
COAD
HGSC 0.978
ccRCC
GBM 0.223
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC 0.198
USP8-Ser452
Cancer Intensity
BRCA 1.452
COAD -0.966
HGSC
ccRCC -1.06
GBM 0.377
HNSC 0.449
LUAD 0.612
LUSC 0.392
non_ccRCC -1.914
PDAC 0.124
UCEC 0.534
USP8-Ser6
Cancer Intensity
BRCA -0.221
COAD -0.234
HGSC 1.816
ccRCC
GBM
HNSC
LUAD -0.336
LUSC -0.121
non_ccRCC 0.93
PDAC -0.235
UCEC -1.597
USP8-Ser641
Cancer Intensity
BRCA -0.307
COAD -0.328
HGSC 2.934
ccRCC -0.624
GBM -0.41
HNSC -0.339
LUAD -0.49
LUSC -0.148
non_ccRCC 0.289
PDAC -0.33
UCEC -0.247
USP8-Ser686
Cancer Intensity
BRCA
COAD
HGSC
ccRCC -0.328
GBM 1.123
HNSC -0.795
LUAD
LUSC
non_ccRCC
PDAC
UCEC
USP8-Ser718
Cancer Intensity
BRCA
COAD -0.412
HGSC -0.299
ccRCC 0.235
GBM -0.106
HNSC 0.473
LUAD 0.934
LUSC
non_ccRCC 1.02
PDAC -2.307
UCEC 0.463
USP8-Ser719
Cancer Intensity
BRCA
COAD -0.542
HGSC 2.232
ccRCC -0.45
GBM -0.618
HNSC -0.273
LUAD -0.215
LUSC
non_ccRCC
PDAC
UCEC -0.135
USP8-Thr379
Cancer Intensity
BRCA 0.104
COAD
HGSC -2.232
ccRCC 0.186
GBM
HNSC
LUAD 0.62
LUSC 0.431
non_ccRCC 0.393
PDAC
UCEC 0.499
USP8-Thr454
Cancer Intensity
BRCA
COAD -0.291
HGSC 1.113
ccRCC
GBM
HNSC -0.823
LUAD
LUSC
non_ccRCC
PDAC
UCEC
USP8-Thr458
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
USP8-Thr577
Cancer Intensity
BRCA -0.583
COAD -0.146
HGSC 2.909
ccRCC -0.318
GBM -0.524
HNSC -0.208
LUAD -0.479
LUSC -0.245
non_ccRCC 0.369
PDAC -0.51
UCEC -0.264
USP8-Thr618
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
USP8-Thr723
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD 0.707
LUSC
non_ccRCC
PDAC
UCEC -0.707
USP8-Tyr717
Cancer Intensity
BRCA
COAD
HGSC
ccRCC 0.615
GBM
HNSC -1.154
LUAD
LUSC
non_ccRCC
PDAC
UCEC 0.539

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: