| Id: | acc1539 |
| Group: | 2sens |
| Protein: | cdc25c |
| Gene Symbol: | CDC25C |
| Protein Id: | P30305 |
| Protein Name: | MPIP2_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser216 |
| Site Sequence: | HPSSTHALAEWASRREAFAQR |
| Disease Category: | Cancer |
| Disease: | Lung Cancer |
| Disease Subtype: | NSCLC |
| Disease Cellline: | A549 |
| Disease Info: | |
| Drug: | LBH589 |
| Drug Info: | LBH589 (Panobinostat) is a histone deacetylase inhibitor approved for the treatment of relapsed or refractory multiple myeloma in combination with other therapies. |
| Effect: | modulate |
| Effect Info: | "Drugs inhibit tumors, which is manifested as the inhibition of protein phosphorylation." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 21179472 |
| Sentence Index: | 21179472_2-3 |
| Sentence: | "METHODS AND FINDINGS: Here, we show that protein levels of checkpoint kinase 1 (Chk1), which has a major role in G(2) cell cycle checkpoint regulation, was markedly reduced at the protein and transcriptional levels in lung cancer cells treated with pan-and selective HDACis LBH589, scriptaid, valproic acid, apicidin, and MS-275. In HDACi treated cells Chk1 function was impaired as determined by decreased inhibitory phosphorylation of cdc25c and its downstream target cdc2 and increased expression of cdc25A and phosphorylated histone H3, a marker of mitotic entry." |
Sequence & Structure:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTAC| CDC25C-Ser216 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.236 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.481 |
| HNSC | 0.035 |
| LUAD | -0.999 |
| LUSC | -1.233 |
| non_ccRCC | |
| PDAC | |
| UCEC | 1.48 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
