Id: | acc1559 |
Group: | 2sens |
Protein: | 70S6K |
Gene Symbol: | RPS6KB1 |
Protein Id: | P23443 |
Protein Name: | KS6B1_HUMAN |
PTM: | phosphorylation |
Site: | Thr389 |
Site Sequence: | SQFDSKFTRQTPVDSPDDSTL |
Disease Category: | Cancer |
Disease: | Esophageal Cancer |
Disease Subtype: | |
Disease Cellline: | ESO26-PAC-r (paclitaxel-resistant) |
Disease Info: | |
Drug: | paclitaxel |
Drug Info: | "Paclitaxel is a plant-derived alkaloid and potent antineoplastic agent that stabilizes microtubules to inhibit cancer cell division, primarily used in the treatment of ovarian, breast, and lung cancers. " |
Effect: | inhibit |
Effect Info: | The anti-helminthic drug niclosamide can effectively overcome the resistance of esophageal cancer cells to paclitaxel by inhibiting the phosphorylation of STAT3 and S6K. |
Note: | |
Score: | 5.0 |
Pubmed(PMID): | 32579788 |
Sentence Index: | 32579788_8-9 |
Sentence: | "Stabilization of beta-catenin level by Wnt activator lithium chloride (LiCl) significantly abolishes the inhibitory effects of niclosamide in inhibiting proliferation and survival but not suppressing phosphorylation of STAT3 and 70S6K in paclitaxel-resistant esophageal cancer cells, suggesting that niclosamide sensitizes esophageal cancer cell to paclitaxel mainly through inhibiting Wnt/beta-catenin. Our work demonstrates the efficacy of niclosamide and its underlying mechanism in paclitaxel-resistant esophageal cancer." |
Sequence & Structure:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
Select PDB:
Target | Drug name | MOA | Phase | Status | Disease | Source |
---|---|---|---|---|---|---|
RPS6KB1 | TAS0612 | Ribosomal protein S6 kinase (P70S6K) inhibitor | 1 | Recruiting | neoplasm | ClinicalTrials |
RPS6KB1 | MSC-2363318A | Ribosomal protein S6 kinase (P70S6K) inhibitor | 1 | Completed | neoplasm | ClinicalTrials |
RPS6KB1 | LY-2780301 | Ribosomal protein S6 kinase (P70S6K) inhibitor | 1 | Completed | lymphoma | ClinicalTrials |
RPS6KB1 | XL-418 | Ribosomal protein S6 kinase (P70S6K) inhibitor | 1 | Suspended | neoplasm | ClinicalTrials |
RPS6KB1 | LY-2584702 | Ribosomal protein S6 kinase 1 inhibitor | 1 | Terminated | renal cell carcinoma | ClinicalTrials |
RPS6KB1 | LY-2584702 | Ribosomal protein S6 kinase 1 inhibitor | 1 | Terminated | non-small cell lung carcinoma | ClinicalTrials |
RPS6KB1 | LY-2584702 | Ribosomal protein S6 kinase 1 inhibitor | 1 | Terminated | metastasis | ClinicalTrials |
RPS6KB1 | LY-2780301 | Ribosomal protein S6 kinase (P70S6K) inhibitor | 1 | Completed | metastasis | ClinicalTrials |
RPS6KB1 | LY-2584702 | Ribosomal protein S6 kinase 1 inhibitor | 1 | Terminated | neuroendocrine neoplasm | ClinicalTrials |
RPS6KB1 | LY-2584702 | Ribosomal protein S6 kinase 1 inhibitor | 1 | Completed | cancer | ClinicalTrials |
RPS6KB1 | LY-2584702 | Ribosomal protein S6 kinase 1 inhibitor | 1 | Terminated | cancer | ClinicalTrials |
RPS6KB1 | XL-418 | Ribosomal protein S6 kinase (P70S6K) inhibitor | 1 | Suspended | cancer | ClinicalTrials |
Note: Only show clinically investigational or approved drugs with protein targets.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACRPS6KB1-Thr389 | |
---|---|
Cancer | Intensity |
BRCA | |
COAD | |
HGSC | |
ccRCC | 0.707 |
GBM | -0.707 |
HNSC | |
LUAD | |
LUSC | |
non_ccRCC | |
PDAC | |
UCEC |
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
T | 389 | P | Liver cancer | Phosphorylation | 23537100 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.