Id: acc1570
Group: 2sens
Protein: Jak2
Gene Symbol: JAK2
Protein Id: O60674
Protein Name: JAK2_HUMAN
PTM: phosphorylation
Site: Tyr1007
Site Sequence: TKVLPQDKEYYKVKEPGESPI
Disease Category: Cancer
Disease: Breast Cancer
Disease Subtype: basal
Disease Cellline: MDA-MB-231
Disease Info:
Drug: paclitaxel
Drug Info: "Paclitaxel is a plant-derived alkaloid and potent antineoplastic agent that stabilizes microtubules to inhibit cancer cell division, primarily used in the treatment of ovarian, breast, and lung cancers. "
Effect: decrease
Effect Info: Silencing B7-H3 enhances the sensitivity of multiple human breast cancer cell lines to paclitaxel and induces drug-related apoptosis by reducing Jak2/Stat3 phosphorylation.
Note:
Score: 5.0
Pubmed(PMID): 21518725
Sentence Index:
Sentence:

Sequence & Structure:

MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
JAK2 BARICITINIB Tyrosine-protein kinase JAK2 inhibitor 4 - immune system disease ATC
JAK2 FILGOTINIB Tyrosine-protein kinase JAK2 inhibitor 4 - immune system disease ATC
JAK2 RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor 4 - neoplasm ATC
JAK2 PACRITINIB Tyrosine-protein kinase JAK2 inhibitor 4 - neoplasm ATC
JAK2 FEDRATINIB Tyrosine-protein kinase JAK2 inhibitor 4 - neoplasm ATC
JAK2 TOFACITINIB CITRATE Janus Kinase (JAK) inhibitor 4 - rheumatoid arthritis DailyMed
DailyMed
JAK2 BARICITINIB Tyrosine-protein kinase JAK2 inhibitor 4 - rheumatoid arthritis FDA
DailyMed
EMA
JAK2 TOFACITINIB CITRATE Janus Kinase (JAK) inhibitor 4 Recruiting rheumatoid arthritis ClinicalTrials
JAK2 BARICITINIB Tyrosine-protein kinase JAK2 inhibitor 4 Recruiting rheumatoid arthritis ClinicalTrials
ClinicalTrials
ClinicalTrials
JAK2 BARICITINIB Tyrosine-protein kinase JAK2 inhibitor 4 Terminated rheumatoid arthritis ClinicalTrials
JAK2 BARICITINIB Tyrosine-protein kinase JAK2 inhibitor 4 Active, not recruiting rheumatoid arthritis ClinicalTrials
JAK2 BARICITINIB Tyrosine-protein kinase JAK2 inhibitor 4 Completed rheumatoid arthritis ClinicalTrials
JAK2 FILGOTINIB MALEATE Tyrosine-protein kinase JAK2 inhibitor 4 - rheumatoid arthritis EMA
JAK2 UPADACITINIB HEMIHYDRATE Tyrosine-protein kinase JAK2 inhibitor 4 - rheumatoid arthritis FDA
DailyMed
JAK2 PACRITINIB CITRATE Tyrosine-protein kinase JAK2 inhibitor 4 - primary myelofibrosis FDA
JAK2 RUXOLITINIB PHOSPHATE Tyrosine-protein kinase JAK2 inhibitor 4 - polycythemia vera EMA
DailyMed
JAK2 PACRITINIB CITRATE Tyrosine-protein kinase JAK2 inhibitor 4 - polycythemia vera FDA
JAK2 RUXOLITINIB PHOSPHATE Tyrosine-protein kinase JAK2 inhibitor 4 - primary myelofibrosis DailyMed
JAK2 FEDRATINIB HYDROCHLORIDE Tyrosine-protein kinase JAK2 inhibitor 4 - primary myelofibrosis FDA
EMA
JAK2 TOFACITINIB CITRATE Janus Kinase (JAK) inhibitor 4 - psoriatic arthritis DailyMed
JAK2 RUXOLITINIB PHOSPHATE Tyrosine-protein kinase JAK2 inhibitor 4 - myeloproliferative disorder EMA
JAK2 FEDRATINIB HYDROCHLORIDE Tyrosine-protein kinase JAK2 inhibitor 4 - myeloproliferative disorder EMA
JAK2 RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor 4 - Eczematoid dermatitis ATC
JAK2 FEDRATINIB HYDROCHLORIDE Tyrosine-protein kinase JAK2 inhibitor 4 - Myelofibrosis DailyMed
JAK2 RUXOLITINIB PHOSPHATE Tyrosine-protein kinase JAK2 inhibitor 4 - Myelofibrosis DailyMed

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
JAK2-Tyr570
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM -0.417
HNSC -0.724
LUAD
LUSC 1.141
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
Y 1007 U Prostate cancer/carcinoma/adenocarcinoma Phosphorylation 22307624

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: