| Id: | acc1589 |
| Group: | 2sens |
| Protein: | CIC |
| Gene Symbol: | Cic |
| Protein Id: | Q924A2 |
| Protein Name: | CIC_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr1455 |
| Site Sequence: | ASTSVSVSTSFSLGSGTFKTQ |
| Disease Category: | Cancer |
| Disease: | Glioma |
| Disease Subtype: | |
| Disease Cellline: | GL261 |
| Disease Info: | |
| Drug: | dasatinib |
| Drug Info: | "Dasatinib is a tyrosine kinase inhibitor that targets BCR-ABL and SRC family kinases, used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), particularly in patients resistant or intolerant to prior therapy including imatinib." |
| Effect: | modulate |
| Effect Info: | "The Src inhibitor dasatinib can prevent EGF-mediated tyrosine phosphorylation of CIC, thereby reducing the survival rate of glioblastoma (GBM) cells and glioma stem cells (GSCs)." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32029440 |
| Sentence Index: | 32029440_6-7 |
| Sentence: | "On the other hand, CIC-mutant allele (CIC-Y1455F), that escapes c-Src-mediated tyrosine phosphorylation, remains localized to the nucleus and retains strong repressor function against CIC targets, the oncogenic transcription factors ETV1 and ETV5. Furthermore, we show that the orally available Src family kinase inhibitor, dasatinib, which prevents EGF-mediated tyrosine phosphorylation of CIC and attenuates elevated ETV1 and ETV5 levels, reduces viability of GBM cells and glioma stem cells (GSC), but not of their control cells with undetectable c-Src activity." |
Sequence & Structure:
MKPMKKACPGLAGSASGSKSPPATRAKALRRRGAGEGDKPEEEEEAQPQEQAGPEEAEEGEEEEAERDPGAEGTHPELQPNDPTPGLTEDPKGDGEAGRWEPSLSRKTATFKSRAPKKKYVEEHGTGNVGVVGAPEERERTPEDASALGVPPRPPTSTRSSSTDTASEHSADLEDEPPEACGPGPWPSTGTSEGYDLRQLRSQRVLARRGDGLFLPAVVRQVRRSQDLGVQFPGDRALTFYEGVPGGGVDVVLDVTPPPGALMVGTAVCTCVEPGVAAYREGVVVEVATKPAAYKVRLSPGPSSHAGPPGTLPQAQQTLHREPEEAVWVTRSSLRLLRPPWEPGALLRKHPAGPEEEQAEPGPALPPCPSSVEPKQPEDAEVSNISFGSNLGTRCEEGEEKHPPSLGTPVLLPLPPPQLLSPPPKSPAFGGPGRPSEQPSPCQEGSQGGSRSSSVASLEKGAAPAARARTPLTAAQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSRHLSMRTKEMEGLADSGPGGTGRPAGVAAREGSTEFDWGDETSRDSEASSVAARGDSRPRLVAPADLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPLFGFRPANFSPINASPVIQRTAVRSRHLSASTPKAGVLTPPDLGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTELLPHPGTLGASGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEARAGGPGRSCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPTLGLASSPFQPVAFHPSPAALLPVLVPSSYPSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHEQPPGGTGGADPGRPPGAVCPESPGPGPPLTLGGVDPGKSLPPTTEEEAPGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPASLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSDTKVPGSGPCGAERLHAVGAPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSPQYGAPGSFAAPGEGGTLATSGRPPLLPSRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDSFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPTLDPEPPGPPDPPAAFSKGYGPTPSSSSSPASTSVSVSTSFSLGSGTFKTQESGQGSTAVPLRPPPPGAGGPATPSKATRFPPTDSATFRRKRPESVGSLEAPGPSVIAAPPSGGGNLLQTLVLPPSKEDREGTRVPSAPAPPLAYGAPAAPLCRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASSNDIAGARTEMGTGSRVPGGSPMGVSLVYSDKKSAAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPASPAVQFIAQGAPGSATPAGSGASTGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTAGIPILQSVPSAPPPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQSAGGHTLPLGTSSACSQTGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSGQAPLLAPGQVGVSPVPSPQLPPACTASGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAATILPKGPPASATATPAPTSPFPSATGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFESGTTGRPGSTPRQSSDSGVAREPAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSSDWRVPGLGLESRGEPPTPPSPAPATGPSGSSSGSSEGSSGRAAGDTPERKEVTSSGKKMKVRPPPLKKTFDSVDKVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTETEDVLGELEYEKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEAPLPGPPPTGMAATPVPTPSPAGGPDPTSPGSDSGTAQVAPPLPPPPEPGPGQPGWEGAPQPSPPPSGPSTAATGR
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
