| Id: | acc1591 |
| Group: | 2sens |
| Protein: | CIC |
| Gene Symbol: | CIC |
| Protein Id: | Q96RK0 |
| Protein Name: | CIC_HUMAN |
| PTM: | phosphorylation |
| Site: | Tyr1455 |
| Site Sequence: | SSPASSSASAATSFSLGSGTF |
| Disease Category: | Cancer |
| Disease: | Glioma |
| Disease Subtype: | |
| Disease Cellline: | GSC-7-2? |
| Disease Info: | |
| Drug: | dasatinib |
| Drug Info: | "Dasatinib is a tyrosine kinase inhibitor that targets BCR-ABL and SRC family kinases, used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), particularly in patients resistant or intolerant to prior therapy including imatinib." |
| Effect: | modulate |
| Effect Info: | "The Src inhibitor dasatinib can prevent EGF-mediated tyrosine phosphorylation of CIC, thereby reducing the survival rate of GBM cells and glioma stem cells (GSC)." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32029440 |
| Sentence Index: | 32029440_6-7 |
| Sentence: | "On the other hand, CIC-mutant allele (CIC-Y1455F), that escapes c-Src-mediated tyrosine phosphorylation, remains localized to the nucleus and retains strong repressor function against CIC targets, the oncogenic transcription factors ETV1 and ETV5. Furthermore, we show that the orally available Src family kinase inhibitor, dasatinib, which prevents EGF-mediated tyrosine phosphorylation of CIC and attenuates elevated ETV1 and ETV5 levels, reduces viability of GBM cells and glioma stem cells (GSC), but not of their control cells with undetectable c-Src activity." |
Sequence & Structure:
MKPMKKACTGLSGPGSGSKSPPATRAKALRRRGAGEGDKPEEEDDEAQQPQPQSGPEEAEEGEEEEAERGPGAEGPPLELHPGDPAPGPAEDPKGDGEAGRWEPSLSRKTATFKSRAPKKKYVEEHGAGSSGVAGAPEERVRTPEEASGLGVPPRPPTSTRSSSTDTASEHSADLEDEPAEACGPGPWPPGSTSGSYDLRQLRSQRVLARRGDGLFLPAVVRQVRRSQDLGVQFPGDRALTFYEGVPGAGVDVVLDATPPPGALVVGTAVCTCVEPGVAAYREGVVVEVATKPAAYKVRLSPGPSSQPGLPGSLPQPPQPLHREPEEAVWVARSSLRLLRPPWEPETMLRKPPTGPEEEQAEPGATLPPCPAALDPKQPEDAEVSKISFGGNLGTHCEEGEEKHPPALGTPALLPLPPPQLLSPPPKSPAFVGPGRPGEQPSPCQEGSQGGSRSSSVASLEKGTAPAARARTPLTAAQQKYKKGDVVCTPSGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSRHLSMRTKEMEGLADSGPGGAGRPAAVAAREGSTEFDWGDETSRDSEASSVAARGDSRPRLVAPADLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPLFGFRPANFSPINASPVIQRTAVRSRHLSASTPKAGVLTPPDLGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTELLPHPGALGAPGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEVRAGGPGRGCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPAFGLASSPFQPVAFHPSPAALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPTSLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSDTKAPGSSSCGAERLHTVGGPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSTQYGAPGPFAAPGEGGALAATGRPPLLPTRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDGFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPGPSVIAAPPSGGGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASPNDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDSVDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPPLPPPPESGPGQPGWEGAPQPSPPPPGPSTAATGR
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| CIC-Ser1082 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.268 | ||||
| COAD | -0.144 | ||||
| HGSC | 0.597 | ||||
| ccRCC | 0.104 | ||||
| GBM | 0.002 | ||||
| HNSC | -1.032 | ||||
| LUAD | 0.484 | ||||
| LUSC | 0.722 | ||||
| non_ccRCC | 0.474 | ||||
| PDAC | -0.034 | ||||
| UCEC | -2.441 | ||||
| CIC-Ser1084 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.707 | ||||
| HGSC | -0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser1186 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.573 | ||||
| HGSC | 0.582 | ||||
| ccRCC | -1.155 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser1188 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.707 | ||||
| HGSC | -0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser12 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.911 | ||||
| GBM | -0.641 | ||||
| HNSC | 1.852 | ||||
| LUAD | 0.043 | ||||
| LUSC | |||||
| non_ccRCC | 0.196 | ||||
| PDAC | -0.539 | ||||
| UCEC | |||||
| CIC-Ser1208 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.196 | ||||
| GBM | |||||
| HNSC | 0.712 | ||||
| LUAD | 0.556 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -1.465 | ||||
| CIC-Ser1210 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.354 | ||||
| HGSC | -1.421 | ||||
| ccRCC | -0.139 | ||||
| GBM | |||||
| HNSC | 1.003 | ||||
| LUAD | 0.911 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser1226 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.204 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -1.018 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.591 | ||||
| LUSC | 0.406 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser1258 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.289 | ||||
| COAD | 1.855 | ||||
| HGSC | -1.398 | ||||
| ccRCC | -0.416 | ||||
| GBM | -0.084 | ||||
| HNSC | 1.591 | ||||
| LUAD | -0.251 | ||||
| LUSC | -0.321 | ||||
| non_ccRCC | 0.505 | ||||
| PDAC | -0.013 | ||||
| UCEC | -1.179 | ||||
| CIC-Ser1340 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.14 | ||||
| COAD | 0.013 | ||||
| HGSC | -2.948 | ||||
| ccRCC | 0.335 | ||||
| GBM | 0.277 | ||||
| HNSC | 0.287 | ||||
| LUAD | 0.403 | ||||
| LUSC | 0.485 | ||||
| non_ccRCC | 0.557 | ||||
| PDAC | 0.515 | ||||
| UCEC | 0.216 | ||||
| CIC-Ser1345 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.818 | ||||
| HGSC | -1.115 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.297 | ||||
| CIC-Ser1405 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.071 | ||||
| HGSC | 2.368 | ||||
| ccRCC | 0.397 | ||||
| GBM | 0.082 | ||||
| HNSC | -0.285 | ||||
| LUAD | -0.137 | ||||
| LUSC | 0.377 | ||||
| non_ccRCC | -1.218 | ||||
| PDAC | -0.337 | ||||
| UCEC | -1.175 | ||||
| CIC-Ser1475 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | 0.707 | ||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser1514 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.947 | ||||
| COAD | -0.551 | ||||
| HGSC | |||||
| ccRCC | -1.182 | ||||
| GBM | -0.038 | ||||
| HNSC | 0.708 | ||||
| LUAD | -0.305 | ||||
| LUSC | 0.941 | ||||
| non_ccRCC | -1.079 | ||||
| PDAC | 0.399 | ||||
| UCEC | -0.84 | ||||
| CIC-Ser1524 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -1.015 | ||||
| GBM | -0.205 | ||||
| HNSC | 1.679 | ||||
| LUAD | -0.188 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.271 | ||||
| CIC-Ser1531 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.707 | ||||
| GBM | |||||
| HNSC | 0.707 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser16 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.798 | ||||
| HGSC | |||||
| ccRCC | -0.896 | ||||
| GBM | 1.575 | ||||
| HNSC | 0.215 | ||||
| LUAD | -0.503 | ||||
| LUSC | |||||
| non_ccRCC | 1.124 | ||||
| PDAC | |||||
| UCEC | -0.718 | ||||
| CIC-Ser1609 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.155 | ||||
| COAD | -0.142 | ||||
| HGSC | -2.235 | ||||
| ccRCC | -0.091 | ||||
| GBM | 0.476 | ||||
| HNSC | -0.089 | ||||
| LUAD | 0.122 | ||||
| LUSC | -0.657 | ||||
| non_ccRCC | |||||
| PDAC | 1.58 | ||||
| UCEC | 0.882 | ||||
| CIC-Ser1630 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.09 | ||||
| COAD | 0.219 | ||||
| HGSC | -2.641 | ||||
| ccRCC | 0.202 | ||||
| GBM | 0.405 | ||||
| HNSC | 0.977 | ||||
| LUAD | |||||
| LUSC | 0.219 | ||||
| non_ccRCC | 0.533 | ||||
| PDAC | 0.57 | ||||
| UCEC | -0.394 | ||||
| CIC-Ser18 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.819 | ||||
| GBM | 0.943 | ||||
| HNSC | 0.704 | ||||
| LUAD | -1.444 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | -0.922 | ||||
| UCEC | -0.099 | ||||
| CIC-Ser1811 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.545 | ||||
| GBM | 1.347 | ||||
| HNSC | |||||
| LUAD | 0.787 | ||||
| LUSC | |||||
| non_ccRCC | -0.858 | ||||
| PDAC | |||||
| UCEC | -0.731 | ||||
| CIC-Ser1813 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.219 | ||||
| HGSC | -2.181 | ||||
| ccRCC | 0.215 | ||||
| GBM | 0.831 | ||||
| HNSC | |||||
| LUAD | 0.648 | ||||
| LUSC | |||||
| non_ccRCC | 0.113 | ||||
| PDAC | |||||
| UCEC | 0.155 | ||||
| CIC-Ser1855 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.816 | ||||
| HGSC | 1.736 | ||||
| ccRCC | -0.443 | ||||
| GBM | -1.005 | ||||
| HNSC | 0.102 | ||||
| LUAD | -0.459 | ||||
| LUSC | -0.605 | ||||
| non_ccRCC | 1.341 | ||||
| PDAC | -0.18 | ||||
| UCEC | -1.303 | ||||
| CIC-Ser1891 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | 0.707 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser20 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.676 | ||||
| COAD | -0.234 | ||||
| HGSC | 1.538 | ||||
| ccRCC | |||||
| GBM | 0.005 | ||||
| HNSC | -0.014 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | -1.992 | ||||
| PDAC | -0.267 | ||||
| UCEC | 0.287 | ||||
| CIC-Ser2059 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.707 | ||||
| CIC-Ser2100 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.707 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser2155 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.88 | ||||
| COAD | 0.208 | ||||
| HGSC | -1.088 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser2203 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.733 | ||||
| COAD | 0.403 | ||||
| HGSC | -2.939 | ||||
| ccRCC | 0.03 | ||||
| GBM | 0.475 | ||||
| HNSC | 0.043 | ||||
| LUAD | 0.243 | ||||
| LUSC | 0.346 | ||||
| non_ccRCC | -0.041 | ||||
| PDAC | 0.303 | ||||
| UCEC | 0.403 | ||||
| CIC-Ser2253 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.395 | ||||
| COAD | |||||
| HGSC | 1.586 | ||||
| ccRCC | 0.213 | ||||
| GBM | 0.822 | ||||
| HNSC | 0.662 | ||||
| LUAD | -0.774 | ||||
| LUSC | 0.085 | ||||
| non_ccRCC | -2.134 | ||||
| PDAC | 0.015 | ||||
| UCEC | -0.08 | ||||
| CIC-Ser2260 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -1.209 | ||||
| ccRCC | -0.868 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | 0.256 | ||||
| LUSC | 1.087 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.733 | ||||
| CIC-Ser227 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.824 | ||||
| COAD | 0.662 | ||||
| HGSC | -2.211 | ||||
| ccRCC | -0.003 | ||||
| GBM | 0.377 | ||||
| HNSC | 0.364 | ||||
| LUAD | 0.539 | ||||
| LUSC | 0.625 | ||||
| non_ccRCC | -1.598 | ||||
| PDAC | 0.654 | ||||
| UCEC | -0.233 | ||||
| CIC-Ser2282 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.993 | ||||
| COAD | 0.027 | ||||
| HGSC | -0.725 | ||||
| ccRCC | 0.909 | ||||
| GBM | 2.02 | ||||
| HNSC | -0.342 | ||||
| LUAD | -0.313 | ||||
| LUSC | 0.881 | ||||
| non_ccRCC | -0.494 | ||||
| PDAC | 0.483 | ||||
| UCEC | -1.453 | ||||
| CIC-Ser2287 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.707 | ||||
| CIC-Ser2291 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.173 | ||||
| COAD | -0.182 | ||||
| HGSC | 1.427 | ||||
| ccRCC | 0.486 | ||||
| GBM | 1.27 | ||||
| HNSC | -0.1 | ||||
| LUAD | -0.865 | ||||
| LUSC | 0.86 | ||||
| non_ccRCC | -1.362 | ||||
| PDAC | -0.066 | ||||
| UCEC | -1.641 | ||||
| CIC-Ser2298 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.546 | ||||
| HGSC | 1.154 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | -0.608 | ||||
| UCEC | |||||
| CIC-Ser2306 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.352 | ||||
| HGSC | -1.772 | ||||
| ccRCC | 0.396 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | 0.343 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.681 | ||||
| CIC-Ser2311 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.225 | ||||
| HGSC | -1.751 | ||||
| ccRCC | 0.469 | ||||
| GBM | |||||
| HNSC | 0.757 | ||||
| LUAD | 0.3 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser2318 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.132 | ||||
| COAD | 0.012 | ||||
| HGSC | -2.597 | ||||
| ccRCC | |||||
| GBM | -0.143 | ||||
| HNSC | 0.772 | ||||
| LUAD | 0.017 | ||||
| LUSC | -0.044 | ||||
| non_ccRCC | 0.133 | ||||
| PDAC | 0.559 | ||||
| UCEC | 0.16 | ||||
| CIC-Ser2327 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.217 | ||||
| COAD | -1.226 | ||||
| HGSC | |||||
| ccRCC | 0.368 | ||||
| GBM | 0.288 | ||||
| HNSC | 0.61 | ||||
| LUAD | -0.047 | ||||
| LUSC | 0.729 | ||||
| non_ccRCC | -2.148 | ||||
| PDAC | 0.465 | ||||
| UCEC | -0.256 | ||||
| CIC-Ser2328 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.783 | ||||
| COAD | 0.867 | ||||
| HGSC | 0.325 | ||||
| ccRCC | 0.431 | ||||
| GBM | -1.244 | ||||
| HNSC | -0.138 | ||||
| LUAD | -0.407 | ||||
| LUSC | -0.187 | ||||
| non_ccRCC | -1.888 | ||||
| PDAC | 0.645 | ||||
| UCEC | -0.188 | ||||
| CIC-Ser2330 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser2331 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.707 | ||||
| CIC-Ser301 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.196 | ||||
| COAD | -1.544 | ||||
| HGSC | -0.89 | ||||
| ccRCC | -0.749 | ||||
| GBM | 1.08 | ||||
| HNSC | 0.43 | ||||
| LUAD | -1.147 | ||||
| LUSC | 1.127 | ||||
| non_ccRCC | 0.249 | ||||
| PDAC | 1.475 | ||||
| UCEC | -0.227 | ||||
| CIC-Ser305 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -1.695 | ||||
| ccRCC | 0.212 | ||||
| GBM | 1.394 | ||||
| HNSC | 0.33 | ||||
| LUAD | -0.143 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.098 | ||||
| CIC-Ser306 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 1.214 | ||||
| HGSC | |||||
| ccRCC | -0.174 | ||||
| GBM | |||||
| HNSC | 0.172 | ||||
| LUAD | -1.211 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser423 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.077 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.003 | ||||
| GBM | -2.21 | ||||
| HNSC | 0.705 | ||||
| LUAD | -0.358 | ||||
| LUSC | 1.026 | ||||
| non_ccRCC | -0.262 | ||||
| PDAC | 1.167 | ||||
| UCEC | 0.006 | ||||
| CIC-Ser428 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.349 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.058 | ||||
| GBM | -1.139 | ||||
| HNSC | 0.449 | ||||
| LUAD | -1.046 | ||||
| LUSC | -1.296 | ||||
| non_ccRCC | -0.076 | ||||
| PDAC | 0.373 | ||||
| UCEC | 1.327 | ||||
| CIC-Ser442 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.025 | ||||
| COAD | 0.281 | ||||
| HGSC | 1.886 | ||||
| ccRCC | -0.175 | ||||
| GBM | -0.225 | ||||
| HNSC | -0.344 | ||||
| LUAD | -1.041 | ||||
| LUSC | -1.474 | ||||
| non_ccRCC | 0.159 | ||||
| PDAC | -0.657 | ||||
| UCEC | 1.566 | ||||
| CIC-Ser448 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.89 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | -1.082 | ||||
| UCEC | 0.192 | ||||
| CIC-Ser452 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.982 | ||||
| HGSC | -1.017 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | 0.035 | ||||
| UCEC | |||||
| CIC-Ser454 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.298 | ||||
| GBM | |||||
| HNSC | 0.481 | ||||
| LUAD | 1.063 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -1.245 | ||||
| CIC-Ser455 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.865 | ||||
| GBM | |||||
| HNSC | 1.095 | ||||
| LUAD | -0.23 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser456 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.188 | ||||
| COAD | |||||
| HGSC | -2.317 | ||||
| ccRCC | 0.516 | ||||
| GBM | 0.719 | ||||
| HNSC | 0.611 | ||||
| LUAD | -0.051 | ||||
| LUSC | |||||
| non_ccRCC | -0.731 | ||||
| PDAC | 0.942 | ||||
| UCEC | 0.122 | ||||
| CIC-Ser459 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -2.427 | ||||
| ccRCC | 0.372 | ||||
| GBM | |||||
| HNSC | 0.511 | ||||
| LUAD | 0.393 | ||||
| LUSC | 0.468 | ||||
| non_ccRCC | -0.086 | ||||
| PDAC | 0.516 | ||||
| UCEC | 0.253 | ||||
| CIC-Ser54 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.48 | ||||
| COAD | |||||
| HGSC | -1.767 | ||||
| ccRCC | |||||
| GBM | 0.32 | ||||
| HNSC | |||||
| LUAD | 0.679 | ||||
| LUSC | 0.288 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser555 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -1.458 | ||||
| ccRCC | 0.161 | ||||
| GBM | |||||
| HNSC | 0.583 | ||||
| LUAD | |||||
| LUSC | 0.714 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser565 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -1.024 | ||||
| HGSC | -0.943 | ||||
| ccRCC | 1.211 | ||||
| GBM | |||||
| HNSC | 1.141 | ||||
| LUAD | 0.141 | ||||
| LUSC | |||||
| non_ccRCC | -0.525 | ||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser664 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.61 | ||||
| COAD | -0.193 | ||||
| HGSC | 2.881 | ||||
| ccRCC | -0.508 | ||||
| GBM | -0.24 | ||||
| HNSC | -0.375 | ||||
| LUAD | -0.754 | ||||
| LUSC | 0.237 | ||||
| non_ccRCC | -0.458 | ||||
| PDAC | 0.026 | ||||
| UCEC | -0.007 | ||||
| CIC-Ser693 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | 0.707 | ||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser710 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.618 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 1.077 | ||||
| HNSC | -0.95 | ||||
| LUAD | -0.745 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser753 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.802 | ||||
| GBM | |||||
| HNSC | -1.12 | ||||
| LUAD | 0.318 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Ser768 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.309 | ||||
| COAD | -0.108 | ||||
| HGSC | 2.808 | ||||
| ccRCC | 0.122 | ||||
| GBM | -0.292 | ||||
| HNSC | -0.442 | ||||
| LUAD | -0.244 | ||||
| LUSC | -0.08 | ||||
| non_ccRCC | -0.503 | ||||
| PDAC | -1.067 | ||||
| UCEC | -0.504 | ||||
| CIC-Ser776 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.75 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.089 | ||||
| GBM | |||||
| HNSC | 0.392 | ||||
| LUAD | -0.127 | ||||
| LUSC | -0.266 | ||||
| non_ccRCC | -1.497 | ||||
| PDAC | 0.181 | ||||
| UCEC | 1.978 | ||||
| CIC-Ser780 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.036 | ||||
| COAD | -0.018 | ||||
| HGSC | -1.574 | ||||
| ccRCC | 0.029 | ||||
| GBM | 2.248 | ||||
| HNSC | 0.278 | ||||
| LUAD | 0.027 | ||||
| LUSC | 0.319 | ||||
| non_ccRCC | -0.896 | ||||
| PDAC | -0.018 | ||||
| UCEC | 0.64 | ||||
| CIC-Ser809 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.678 | ||||
| COAD | -0.509 | ||||
| HGSC | 2.647 | ||||
| ccRCC | -0.274 | ||||
| GBM | -0.747 | ||||
| HNSC | -0.069 | ||||
| LUAD | -0.178 | ||||
| LUSC | 1.044 | ||||
| non_ccRCC | -0.362 | ||||
| PDAC | -0.385 | ||||
| UCEC | -0.487 | ||||
| CIC-Thr1080 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.543 | ||||
| GBM | |||||
| HNSC | 1.154 | ||||
| LUAD | -0.611 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr1212 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.148 | ||||
| HGSC | |||||
| ccRCC | -1.038 | ||||
| GBM | |||||
| HNSC | 1.367 | ||||
| LUAD | -0.181 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr1214 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -1.154 | ||||
| GBM | |||||
| HNSC | 0.601 | ||||
| LUAD | 0.553 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr1344 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.566 | ||||
| HGSC | -1.73 | ||||
| ccRCC | 0.53 | ||||
| GBM | |||||
| HNSC | 0.639 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.005 | ||||
| CIC-Thr143 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.066 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.342 | ||||
| GBM | |||||
| HNSC | 1.779 | ||||
| LUAD | 0.23 | ||||
| LUSC | -0.365 | ||||
| non_ccRCC | -1.236 | ||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr1476 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.707 | ||||
| GBM | |||||
| HNSC | -0.707 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr1492 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.593 | ||||
| COAD | 0.077 | ||||
| HGSC | 2.787 | ||||
| ccRCC | -0.281 | ||||
| GBM | -0.559 | ||||
| HNSC | 0.082 | ||||
| LUAD | -0.816 | ||||
| LUSC | -0.722 | ||||
| non_ccRCC | -0.425 | ||||
| PDAC | 0.27 | ||||
| UCEC | 0.181 | ||||
| CIC-Thr1613 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.707 | ||||
| HGSC | -0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr2126 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | -0.707 | ||||
| PDAC | |||||
| UCEC | 0.707 | ||||
| CIC-Thr2137 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.083 | ||||
| HGSC | -1.296 | ||||
| ccRCC | |||||
| GBM | 1.115 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.264 | ||||
| CIC-Thr2149 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | 0.707 | ||||
| UCEC | |||||
| CIC-Thr2200 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.384 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -1.556 | ||||
| GBM | 0.329 | ||||
| HNSC | -1.142 | ||||
| LUAD | -0.524 | ||||
| LUSC | -0.074 | ||||
| non_ccRCC | 0.173 | ||||
| PDAC | 0.016 | ||||
| UCEC | 1.393 | ||||
| CIC-Thr2227 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -1.044 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.316 | ||||
| LUSC | 1.345 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.015 | ||||
| CIC-Thr2250 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr2290 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.238 | ||||
| HGSC | 0.184 | ||||
| ccRCC | -0.119 | ||||
| GBM | 1.236 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -1.539 | ||||
| CIC-Thr2307 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.27 | ||||
| HGSC | -1.973 | ||||
| ccRCC | 0.589 | ||||
| GBM | |||||
| HNSC | 0.754 | ||||
| LUAD | 0.346 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.014 | ||||
| CIC-Thr2317 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.037 | ||||
| HGSC | -1.933 | ||||
| ccRCC | 0.055 | ||||
| GBM | 1.478 | ||||
| HNSC | 0.06 | ||||
| LUAD | 0.206 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.172 | ||||
| CIC-Thr24 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr410 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | 0.707 | ||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr472 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.116 | ||||
| COAD | -0.059 | ||||
| HGSC | 2.968 | ||||
| ccRCC | -0.241 | ||||
| GBM | -0.465 | ||||
| HNSC | -0.219 | ||||
| LUAD | -0.47 | ||||
| LUSC | -0.193 | ||||
| non_ccRCC | -0.664 | ||||
| PDAC | -0.203 | ||||
| UCEC | -0.338 | ||||
| CIC-Thr556 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -1.153 | ||||
| ccRCC | 0.515 | ||||
| GBM | |||||
| HNSC | 0.637 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr564 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.803 | ||||
| HGSC | -1.043 | ||||
| ccRCC | 1.263 | ||||
| GBM | |||||
| HNSC | 1.123 | ||||
| LUAD | 0.094 | ||||
| LUSC | |||||
| non_ccRCC | -0.634 | ||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr674 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.082 | ||||
| COAD | 0.406 | ||||
| HGSC | 0.684 | ||||
| ccRCC | -0.622 | ||||
| GBM | 2.098 | ||||
| HNSC | 0.142 | ||||
| LUAD | -0.684 | ||||
| LUSC | -0.259 | ||||
| non_ccRCC | -1.768 | ||||
| PDAC | 0.709 | ||||
| UCEC | -0.624 | ||||
| CIC-Thr698 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.394 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 1.036 | ||||
| GBM | |||||
| HNSC | -1.521 | ||||
| LUAD | 0.631 | ||||
| LUSC | 0.247 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr701 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | 0.707 | ||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Thr755 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| CIC-Tyr2299 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| Y | 1455 | U | Glioblastoma | Phosphorylation | 32029440 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
