| Id: | acc1597 |
| Group: | 2sens |
| Protein: | p90RSK2 |
| Gene Symbol: | RPS6KA2 |
| Protein Id: | Q15349 |
| Protein Name: | KS6A2_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser363 |
| Site Sequence: | ARTPTDSPGVPPSANAHHLFR |
| Disease Category: | Cancer |
| Disease: | Lung Cancer |
| Disease Subtype: | LUSC |
| Disease Cellline: | H226B |
| Disease Info: | |
| Drug: | Kazinol-E |
| Drug Info: | - |
| Effect: | modulate |
| Effect Info: | The drug reduces the phosphorylation level of the ERK substrate p90RSK2 and inhibits tumors. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 26774343 |
| Sentence Index: | 26774343_5-6 |
| Sentence: | "Kazinol-E did not decrease EGF-induced ERK phosphorylation in CSLCs, but did block the phosphorylation of an ERK substrate, p90RSK2, at Thr359/Ser363. We further demonstrated that EGF-induced ERK activity was blocked by Kazinol-E in a wild-type K-Ras-expressing non-small cell lung cancer cell line H226B." |
Sequence & Structure:
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL
No data.
| Target | Drug name | MOA | Phase | Status | Disease | Source |
|---|---|---|---|---|---|---|
| RPS6KA2 | TAS0612 | p90RSK inhibitor | 1 | Recruiting | neoplasm | ClinicalTrials |
Note: Only show clinically investigational or approved drugs with protein targets.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| RPS6KA2-Ser214 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | 0.707 |
| UCEC | -0.707 |
| RPS6KA2-Ser385 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.65 |
| HGSC | |
| ccRCC | |
| GBM | -0.116 |
| HNSC | |
| LUAD | 0.488 |
| LUSC | -1.143 |
| non_ccRCC | 1.421 |
| PDAC | |
| UCEC | |
| RPS6KA2-Ser389 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.707 |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| RPS6KA2-Thr230 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.596 |
| HNSC | |
| LUAD | -0.205 |
| LUSC | 0.928 |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.319 |
| RPS6KA2-Thr578 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.881 |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 1.087 |
| LUSC | |
| non_ccRCC | -0.205 |
| PDAC | |
| UCEC | |
| RPS6KA2-Tyr685 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.707 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.707 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
