| Id: | acc1674 |
| Group: | 2sens |
| Protein: | Rb |
| Gene Symbol: | RB1 |
| Protein Id: | P06400 |
| Protein Name: | RB_HUMAN |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cancer |
| Disease: | Breast Cancer |
| Disease Subtype: | |
| Disease Cellline: | MCF7 |
| Disease Info: | |
| Drug: | apigenin |
| Drug Info: | "Apigenin is a naturally occurring flavonoid compound with demonstrated potential as an antifungal agent in the preparation of drugs against human fungal infections, and it is also being researched in drug delivery systems such as solid lipid nanoparticles (APG-SLNP) to enhance stability and bioavailability. " |
| Effect: | modulate |
| Effect Info: | "Apigenin also significantly reduced the phosphorylation of Rb in MCF - 7 cells and inhibited the phosphorylation and activation of ERK MAP kinase in MDA - MB - 468 cells in a dose - and time - dependent manner, thereby inhibiting the growth of MCF - 7 and MDA - MB - 468 breast cancer cells." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 11299771 |
| Sentence Index: | 11299771_1-2 |
| Sentence: | "We have previously reported that apigenin inhibits the growth of thyroid cancer cells by attenuating epidermal growth factor receptor (EGF-R) tyrosine phosphorylation and phosphorylation of ERK mitogen-activated protein (MAP) kinase. In this study, we assessed the growth inhibitory effect of apigenin on MCF-7 breast carcinoma cells that express two key cell cycle regulators, wild-type p53 and the retinoblastoma tumor suppressor protein (Rb), and MDA-MB-468 breast carcinoma cells that are mutant for p53 and Rb negative." |
Sequence & Structure:
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| ADARB1-Ser26 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.758 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.249 | ||||
| GBM | |||||
| HNSC | -1.731 | ||||
| LUAD | 1.131 | ||||
| LUSC | -0.166 | ||||
| non_ccRCC | |||||
| PDAC | -0.242 | ||||
| UCEC | |||||
| ARRB1-Ser412 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -2.747 | ||||
| COAD | 0.416 | ||||
| HGSC | 0.725 | ||||
| ccRCC | 0.271 | ||||
| GBM | 0.058 | ||||
| HNSC | 0.463 | ||||
| LUAD | -0.02 | ||||
| LUSC | 0.615 | ||||
| non_ccRCC | |||||
| PDAC | -0.068 | ||||
| UCEC | 0.288 | ||||
| ARRB1-Thr374 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | 0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| ARRB1-Thr381 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.355 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.153 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.796 | ||||
| LUSC | -0.712 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| ARRB1-Thr410 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.893 | ||||
| HGSC | |||||
| ccRCC | 0.327 | ||||
| GBM | -0.792 | ||||
| HNSC | 0.709 | ||||
| LUAD | 0.859 | ||||
| LUSC | -1.784 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.212 | ||||
| GRB10-Ser104 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.858 | ||||
| COAD | 1.193 | ||||
| HGSC | |||||
| ccRCC | 0.679 | ||||
| GBM | -2.113 | ||||
| HNSC | 0.121 | ||||
| LUAD | -0.87 | ||||
| LUSC | 0.821 | ||||
| non_ccRCC | 0.345 | ||||
| PDAC | 0.101 | ||||
| UCEC | 0.581 | ||||
| GRB10-Ser150 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 1.426 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -1.401 | ||||
| HNSC | -1.073 | ||||
| LUAD | |||||
| LUSC | 0.411 | ||||
| non_ccRCC | -0.162 | ||||
| PDAC | -0.012 | ||||
| UCEC | 0.811 | ||||
| GRB10-Ser372 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.274 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.625 | ||||
| HNSC | |||||
| LUAD | 0.743 | ||||
| LUSC | |||||
| non_ccRCC | 1.197 | ||||
| PDAC | |||||
| UCEC | -0.041 | ||||
| GRB10-Ser382 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 1.153 | ||||
| HNSC | -0.635 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.518 | ||||
| GRB10-Ser385 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.112 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 0.825 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.287 | ||||
| GRB14-Ser271 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.707 | ||||
| GRB14-Ser274 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.707 | ||||
| GRB14-Ser285 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.188 | ||||
| HGSC | |||||
| ccRCC | -0.056 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.311 | ||||
| LUSC | |||||
| non_ccRCC | 1.963 | ||||
| PDAC | -0.808 | ||||
| UCEC | -0.6 | ||||
| GRB14-Ser288 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.705 | ||||
| LUSC | |||||
| non_ccRCC | 1.144 | ||||
| PDAC | |||||
| UCEC | -0.439 | ||||
| GRB14-Thr9 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.214 | ||||
| COAD | 0.689 | ||||
| HGSC | 0.334 | ||||
| ccRCC | 0.048 | ||||
| GBM | |||||
| HNSC | -1.989 | ||||
| LUAD | -0.156 | ||||
| LUSC | 0.796 | ||||
| non_ccRCC | 1.394 | ||||
| PDAC | -1.344 | ||||
| UCEC | 0.015 | ||||
| LILRB1-Ser523 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| LILRB1-Ser578 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -1.146 | ||||
| GBM | 0.696 | ||||
| HNSC | |||||
| LUAD | 0.45 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| LILRB1-Ser581 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.573 | ||||
| COAD | 1.02 | ||||
| HGSC | 0.143 | ||||
| ccRCC | -1.924 | ||||
| GBM | 0.631 | ||||
| HNSC | |||||
| LUAD | 0.321 | ||||
| LUSC | 0.457 | ||||
| non_ccRCC | |||||
| PDAC | -1.463 | ||||
| UCEC | 0.241 | ||||
| LILRB1-Thr496 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1-Ser249 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.68 | ||||
| COAD | -0.657 | ||||
| HGSC | 2.327 | ||||
| ccRCC | 0.04 | ||||
| GBM | 0 | ||||
| HNSC | -0.544 | ||||
| LUAD | -0.158 | ||||
| LUSC | -1.828 | ||||
| non_ccRCC | 0.079 | ||||
| PDAC | -0.068 | ||||
| UCEC | 0.13 | ||||
| RB1-Ser350 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -0.512 | ||||
| ccRCC | 1.226 | ||||
| GBM | 0.425 | ||||
| HNSC | |||||
| LUAD | -1.408 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.268 | ||||
| RB1-Ser360 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.52 | ||||
| GBM | |||||
| HNSC | -0.909 | ||||
| LUAD | 0.049 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 1.379 | ||||
| RB1-Ser37 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.127 | ||||
| COAD | -0.722 | ||||
| HGSC | -2.548 | ||||
| ccRCC | 0.026 | ||||
| GBM | 0.866 | ||||
| HNSC | 0.522 | ||||
| LUAD | 0.082 | ||||
| LUSC | 0.313 | ||||
| non_ccRCC | -0.192 | ||||
| PDAC | 0.194 | ||||
| UCEC | 1.33 | ||||
| RB1-Ser773 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.392 | ||||
| HGSC | 1.137 | ||||
| ccRCC | -0.745 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1-Ser780 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.203 | ||||
| HGSC | 0.883 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | -1.086 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1-Ser788 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.245 | ||||
| HGSC | 1.955 | ||||
| ccRCC | -0.485 | ||||
| GBM | -0.194 | ||||
| HNSC | -0.912 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.118 | ||||
| RB1-Ser794 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | 1.077 | ||||
| ccRCC | -0.178 | ||||
| GBM | |||||
| HNSC | -0.899 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1-Ser795 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1 | ||||
| COAD | |||||
| HGSC | 1.314 | ||||
| ccRCC | 0.252 | ||||
| GBM | |||||
| HNSC | -0.957 | ||||
| LUAD | -0.782 | ||||
| LUSC | -0.826 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1-Ser807 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.643 | ||||
| HGSC | -0.466 | ||||
| ccRCC | |||||
| GBM | -0.785 | ||||
| HNSC | -0.414 | ||||
| LUAD | 1.544 | ||||
| LUSC | -0.86 | ||||
| non_ccRCC | |||||
| PDAC | 1.566 | ||||
| UCEC | 0.058 | ||||
| RB1-Ser811 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.326 | ||||
| COAD | -0.737 | ||||
| HGSC | 1.982 | ||||
| ccRCC | |||||
| GBM | -0.759 | ||||
| HNSC | 0.242 | ||||
| LUAD | |||||
| LUSC | -1.24 | ||||
| non_ccRCC | |||||
| PDAC | 0.434 | ||||
| UCEC | -0.248 | ||||
| RB1-Ser816 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.619 | ||||
| GBM | |||||
| HNSC | -1.154 | ||||
| LUAD | 0.535 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1-Ser919 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -1.116 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | 0.303 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.814 | ||||
| RB1-Thr252 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.392 | ||||
| HGSC | 0.883 | ||||
| ccRCC | |||||
| GBM | 0.465 | ||||
| HNSC | 0.788 | ||||
| LUAD | -1.849 | ||||
| LUSC | 1.098 | ||||
| non_ccRCC | |||||
| PDAC | -0.735 | ||||
| UCEC | -0.259 | ||||
| RB1-Thr353 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | -0.927 | ||||
| LUAD | -0.133 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 1.06 | ||||
| RB1-Thr356 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.816 | ||||
| HGSC | 0.881 | ||||
| ccRCC | |||||
| GBM | -0.914 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.85 | ||||
| RB1-Thr373 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 2.526 | ||||
| COAD | -0.21 | ||||
| HGSC | 0.331 | ||||
| ccRCC | -0.437 | ||||
| GBM | -0.531 | ||||
| HNSC | 0.068 | ||||
| LUAD | -1.274 | ||||
| LUSC | 0.565 | ||||
| non_ccRCC | -0.98 | ||||
| PDAC | -0.234 | ||||
| UCEC | 0.175 | ||||
| RB1-Thr625 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1-Thr821 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.976 | ||||
| COAD | -0.972 | ||||
| HGSC | 1.995 | ||||
| ccRCC | 0.136 | ||||
| GBM | -1.166 | ||||
| HNSC | -0.796 | ||||
| LUAD | -1.285 | ||||
| LUSC | 0.502 | ||||
| non_ccRCC | 0.11 | ||||
| PDAC | 0.058 | ||||
| UCEC | 0.442 | ||||
| RB1-Thr823 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.397 | ||||
| HGSC | 1.637 | ||||
| ccRCC | 0.402 | ||||
| GBM | -0.756 | ||||
| HNSC | -0.739 | ||||
| LUAD | -0.94 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1-Thr826 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.304 | ||||
| HGSC | 1.634 | ||||
| ccRCC | -0.211 | ||||
| GBM | -0.249 | ||||
| HNSC | 0.091 | ||||
| LUAD | |||||
| LUSC | -1.913 | ||||
| non_ccRCC | |||||
| PDAC | 0.397 | ||||
| UCEC | 0.553 | ||||
| RB1-Tyr805 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.754 | ||||
| GBM | 0.358 | ||||
| HNSC | -1.474 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.362 | ||||
| RB1-Tyr813 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.06 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | 0.969 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -1.029 | ||||
| RB1CC1-Ser1221 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.86 | ||||
| GBM | |||||
| HNSC | 0.238 | ||||
| LUAD | -1.097 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1CC1-Ser1222 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.837 | ||||
| COAD | |||||
| HGSC | 0.381 | ||||
| ccRCC | -0.417 | ||||
| GBM | |||||
| HNSC | -0.488 | ||||
| LUAD | -1.199 | ||||
| LUSC | 0.92 | ||||
| non_ccRCC | -0.872 | ||||
| PDAC | -0.161 | ||||
| UCEC | |||||
| RB1CC1-Ser1370 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | -0.707 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1CC1-Ser212 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | -0.707 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1CC1-Ser222 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.315 | ||||
| COAD | -0.826 | ||||
| HGSC | 2.492 | ||||
| ccRCC | 0.06 | ||||
| GBM | 0.03 | ||||
| HNSC | -0.676 | ||||
| LUAD | -0.198 | ||||
| LUSC | -0.199 | ||||
| non_ccRCC | 0.872 | ||||
| PDAC | 0.031 | ||||
| UCEC | -0.272 | ||||
| RB1CC1-Ser229 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -1.151 | ||||
| HGSC | 1.565 | ||||
| ccRCC | -1.026 | ||||
| GBM | 0.236 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | 0.345 | ||||
| PDAC | |||||
| UCEC | 0.031 | ||||
| RB1CC1-Ser237 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.759 | ||||
| COAD | -0.82 | ||||
| HGSC | -1.608 | ||||
| ccRCC | |||||
| GBM | -0.344 | ||||
| HNSC | 1.701 | ||||
| LUAD | -0.154 | ||||
| LUSC | 0.98 | ||||
| non_ccRCC | 0.638 | ||||
| PDAC | 0.773 | ||||
| UCEC | -0.405 | ||||
| RB1CC1-Ser243 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -0.877 | ||||
| ccRCC | |||||
| GBM | -1.087 | ||||
| HNSC | -0.047 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | 1.123 | ||||
| PDAC | |||||
| UCEC | 0.887 | ||||
| RB1CC1-Ser257 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.178 | ||||
| HGSC | 1.433 | ||||
| ccRCC | |||||
| GBM | -0.375 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.88 | ||||
| RB1CC1-Ser261 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | -0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1CC1-Ser266 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.395 | ||||
| HGSC | 1.137 | ||||
| ccRCC | |||||
| GBM | -0.742 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1CC1-Ser624 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.431 | ||||
| HGSC | 1.036 | ||||
| ccRCC | -1.189 | ||||
| GBM | -0.506 | ||||
| HNSC | 1.178 | ||||
| LUAD | -0.79 | ||||
| LUSC | -1.571 | ||||
| non_ccRCC | -0.239 | ||||
| PDAC | 0.532 | ||||
| UCEC | 1.119 | ||||
| RB1CC1-Ser629 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.223 | ||||
| GBM | |||||
| HNSC | 0.87 | ||||
| LUAD | -1.093 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1CC1-Ser642 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.638 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.026 | ||||
| GBM | |||||
| HNSC | 0.459 | ||||
| LUAD | 1.038 | ||||
| LUSC | 0.168 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1CC1-Ser644 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.13 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.189 | ||||
| GBM | 0.924 | ||||
| HNSC | 0.834 | ||||
| LUAD | |||||
| LUSC | -1.359 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.541 | ||||
| RB1CC1-Ser647 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.197 | ||||
| COAD | 0.454 | ||||
| HGSC | 0.022 | ||||
| ccRCC | |||||
| GBM | 1.053 | ||||
| HNSC | 0.523 | ||||
| LUAD | -0.291 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | 1.084 | ||||
| UCEC | -1.649 | ||||
| RB1CC1-Ser650 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -0.858 | ||||
| ccRCC | |||||
| GBM | 0.061 | ||||
| HNSC | |||||
| LUAD | 1.384 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.587 | ||||
| RB1CC1-Ser653 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.574 | ||||
| HGSC | -1.47 | ||||
| ccRCC | |||||
| GBM | 0.433 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | 0.694 | ||||
| PDAC | |||||
| UCEC | 0.917 | ||||
| RB1CC1-Ser982 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | -0.707 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1CC1-Thr238 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.249 | ||||
| HNSC | 1.101 | ||||
| LUAD | -0.852 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RB1CC1-Thr631 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.043 | ||||
| GBM | |||||
| HNSC | 1.021 | ||||
| LUAD | -0.978 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SCARB1-Ser493 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | -0.707 | ||||
| PDAC | |||||
| UCEC | |||||
| SCARB1-Ser502 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | -0.707 | ||||
| PDAC | |||||
| UCEC | |||||
| URB1-Ser9 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.354 | ||||
| COAD | |||||
| HGSC | 1.473 | ||||
| ccRCC | |||||
| GBM | -0.757 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | -0.362 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| ZCRB1-Ser155 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.425 | ||||
| COAD | 0.015 | ||||
| HGSC | -2.564 | ||||
| ccRCC | 0.322 | ||||
| GBM | |||||
| HNSC | 0.426 | ||||
| LUAD | 0.131 | ||||
| LUSC | 0.151 | ||||
| non_ccRCC | |||||
| PDAC | 0.146 | ||||
| UCEC | 0.947 | ||||
| ZCRB1-Ser216 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| - | - | D | Colon cancer/carcinoma | Phosphorylation | 11032757 |
| - | - | P | Head and neck squamous cell carcinoma | Phosphorylation | 23414419 |
| - | - | P | Lung cancer/carcinoma | Phosphorylation | 9393586 |
| - | - | U | Hepatocellular carcinoma | Phosphorylation | 36031658 |
| - | - | U | Ulcerative colitis | Phosphorylation | 23967107 |
| - | - | U | Crohn's disease | Phosphorylation | 23967107 |
| - | - | U | Breast cancer/tumor/carcinoma | Phosphorylation | 23686806 |
| - | - | U | Pancreatic cancer/carcinoma/adenocarcinoma | Phosphorylation | 24107447 |
| - | - | U | Pancreatic cancer/carcinoma/adenocarcinoma | Phosphorylation | 24334458 |
| - | - | U | Neuroblastoma | Phosphorylation | 10644979 |
| - | - | U | Breast cancer/tumor/carcinoma | Phosphorylation | 10860819 |
| - | - | U | Neuroblastoma | Phosphorylation | 16824683 |
| - | - | U | Nasopharyngeal carcinoma | Phosphorylation | 18697201 |
| - | - | U | Retinoblastoma | Phosphorylation | 11900540 |
| - | - | U | Acute lymphoblastic leukemia | Phosphorylation | 11380466 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
