PMADS

Id:	acc1682
Group:	2sens
Protein:	ERG
Gene Symbol:	ERG
Protein Id:	P11308
Protein Name:	ERG_HUMAN
PTM:	phosphorylation
Site:	Ser96
Site Sequence:	VAKGGKMVGSPDTVGMNYGSY
Disease Category:	Cancer
Disease:	Prostate Cancer
Disease Subtype:
Disease Cellline:	HEK293T
Disease Info:
Drug:	TAK-242
Drug Info:	"TAK-242 (Resatorvid) is a selective Toll-like receptor 4 (TLR4) inhibitor that suppresses the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) with IC50 values of 1.8 nM, 1.9 nM, and 1.3 nM, respectively."
Effect:	modulate
Effect Info:	Drugs inhibit protein phosphorylation and suppress tumors.
Note:
Score:	4.0
Pubmed(PMID):	33554122
Sentence Index:	33554122_4-5
Sentence:	"Our data confirm previous reports that ERG can transcriptionally activate TLR4 gene expression; however, using a constitutively active ERG mutant, we demonstrate that the critical function of TLR4 signaling is upstream, promoting ERG phosphorylation at serine 96 and ERG transcriptional activation. The TLR4 inhibitor, TAK-242, attenuated ERG-mediated migration, clonogenic survival, target gene activation and tumor growth."

Sequence & Structure:

MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

Small molecule

Antibody

PROTAC

Other modalities

Approved Drug

Advanced Clinical

Phase 1 Clinical

Structure with Ligand

High-Quality Ligand

High-Quality Pocket

Med-Quality Pocket

Druggable Family

Approved Drug

Advanced Clinical

Phase 1 Clinical

UniProt loc high conf

GO CC high conf

UniProt loc med conf

UniProt SigP or TMHMM

GO CC med conf

Human Protein Atlas loc

Approved Drug

Advanced Clinical

Phase 1 Clinical

Literature

UniProt Ubiquitination

Database Ubiquitination

Half-life Data

Small Molecule Binder

Approved Drug

Advanced Clinical

Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

ERG-Ser103
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

ERG-Ser222
Cancer	Intensity
BRCA
COAD	0.113
HGSC	1.493
ccRCC	-2.236
GBM	0.424
HNSC	0.39
LUAD	-0.417
LUSC	0.089
non_ccRCC	0.65
PDAC	0.337
UCEC	-0.843

ERG-Ser283
Cancer	Intensity
BRCA	0.836
COAD
HGSC
ccRCC	-0.92
GBM	1.898
HNSC	-0.628
LUAD	0.416
LUSC	-0.196
non_ccRCC	-1.299
PDAC	0.473
UCEC	-0.579

ERG-Ser373
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC	-0.707
UCEC

ERG-Ser80
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.707
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC

ERG-Ser85
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.584
GBM	0.392
HNSC	0.931
LUAD	-0.314
LUSC
non_ccRCC
PDAC
UCEC	-1.594

ERG-Ser88
Cancer	Intensity
BRCA	1.463
COAD	0.332
HGSC	-2.082
ccRCC	0.56
GBM	0.383
HNSC	0.753
LUAD	0.273
LUSC	-0.052
non_ccRCC	-0.568
PDAC	0.312
UCEC	-1.375

ERG-Thr106
Cancer	Intensity
BRCA	0.707
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC	-0.707
UCEC

ERG-Tyr369
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC	-0.707
UCEC

ERGIC3-Ser116
Cancer	Intensity
BRCA
COAD
HGSC	1.908
ccRCC	-0.024
GBM	-0.155
HNSC	-0.897
LUAD
LUSC
non_ccRCC
PDAC	-0.719
UCEC	-0.112

ERGIC3-Ser117
Cancer	Intensity
BRCA
COAD
HGSC	0.707
ccRCC	-0.707
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

RERG-Ser162
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC	-0.707
non_ccRCC
PDAC	0.707
UCEC

RERG-Ser163
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC	-0.707
non_ccRCC
PDAC	0.707
UCEC

TCERG1-Thr570
Cancer	Intensity
BRCA	-0.525
COAD
HGSC
ccRCC	-0.973
GBM
HNSC	1.234
LUAD	-0.648
LUSC
non_ccRCC
PDAC	0.913
UCEC

PTM-Disease Association:

source: PTMD

Residue	Position	State	Disease	Class	PMID
S	96	U	Prostate cancer	Phosphorylation	33554122

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb