PMADS

Id:	acc1773
Group:	2sens
Protein:	FOXO1
Gene Symbol:	FOXO1
Protein Id:	Q12778
Protein Name:	FOXO1_HUMAN
PTM:	phosphorylation
Site:	Thr24
Site Sequence:	EPLPRPRSCTWPLPRPEFSQS
Disease Category:	Cancer
Disease:	Colorectal Cancer
Disease Subtype:
Disease Cellline:	HT29
Disease Info:
Drug:	rapamycin
Drug Info:	"Rapamycin is a macrolide immunosuppressant and antiproliferative drug used primarily to prevent organ transplant rejection and in cancer therapy, requiring regular monitoring of blood drug concentrations due to its narrow therapeutic index."
Effect:	inhibit
Effect Info:	"Rapamycin-induced inactivation of FOXO1 reduces the antitumor effect of rapamycin. Rapamycin causes phosphorylation of FOXO1 and its transfer from the nucleus to the cytoplasm, thereby inactivating FOXO1."
Note:
Score:	5.0
Pubmed(PMID):	20392999
Sentence Index:	20392999_3-4
Sentence:	MATERIALS AND METHODS: Colon cancer cells were treated with rapamycin and FOXO1 phosphorylation was determined by Western blot. Colon cancer cells transfected with a constitutively active mutant of FOXO1 or a control plasmid were treated with rapamycin and the antiproliferative efficacy of rapamycin was monitored.

Sequence & Structure:

MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGRPLPHTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNGYGRMGLLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

Small molecule

Antibody

PROTAC

Other modalities

Approved Drug

Advanced Clinical

Phase 1 Clinical

Structure with Ligand

High-Quality Ligand

High-Quality Pocket

Med-Quality Pocket

Druggable Family

Approved Drug

Advanced Clinical

Phase 1 Clinical

UniProt loc high conf

GO CC high conf

UniProt loc med conf

UniProt SigP or TMHMM

GO CC med conf

Human Protein Atlas loc

Approved Drug

Advanced Clinical

Phase 1 Clinical

Literature

UniProt Ubiquitination

Database Ubiquitination

Half-life Data

Small Molecule Binder

Approved Drug

Advanced Clinical

Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

FOXO1-Ser218
Cancer	Intensity
BRCA	1.611
COAD
HGSC
ccRCC
GBM	-0.033
HNSC
LUAD
LUSC	-0.786
non_ccRCC
PDAC	-0.882
UCEC	0.089

FOXO1-Ser256
Cancer	Intensity
BRCA	-0.041
COAD
HGSC	1.442
ccRCC
GBM	-0.737
HNSC	0.067
LUAD	-0.248
LUSC	-0.693
non_ccRCC	1.745
PDAC	-0.217
UCEC	-1.318

FOXO1-Ser276
Cancer	Intensity
BRCA	1.669
COAD
HGSC
ccRCC
GBM	0.177
HNSC	0.233
LUAD	0.118
LUSC	-0.216
non_ccRCC
PDAC	-0.248
UCEC	-1.734

FOXO1-Ser279
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.926
GBM
HNSC	-0.135
LUAD	1.061
LUSC
non_ccRCC
PDAC
UCEC

FOXO1-Ser287
Cancer	Intensity
BRCA	0.191
COAD	0.213
HGSC	-2.766
ccRCC	0.482
GBM	0.205
HNSC	0.041
LUAD	0.127
LUSC	0.229
non_ccRCC	1.379
PDAC	0.042
UCEC	-0.142

FOXO1-Ser290
Cancer	Intensity
BRCA
COAD	0.707
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.707

FOXO1-Ser298
Cancer	Intensity
BRCA	0.714
COAD	-0.074
HGSC
ccRCC	-0.663
GBM	-0.928
HNSC	-0.11
LUAD	0.011
LUSC	0.835
non_ccRCC	1.974
PDAC	-0.162
UCEC	-1.597

FOXO1-Ser301
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.966
HNSC	-1.031
LUAD	0.065
LUSC
non_ccRCC
PDAC
UCEC

FOXO1-Ser303
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	-0.653
HNSC	1.461
LUAD
LUSC
non_ccRCC
PDAC	-0.642
UCEC	-0.166

FOXO1-Ser319
Cancer	Intensity
BRCA
COAD	0.846
HGSC	-1.441
ccRCC
GBM	0.423
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.172

FOXO1-Ser322
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

FOXO1-Ser329
Cancer	Intensity
BRCA
COAD	0.095
HGSC	-0.665
ccRCC
GBM	1.377
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.808

FOXO1-Ser470
Cancer	Intensity
BRCA
COAD	-0.366
HGSC	1.256
ccRCC
GBM
HNSC	0.224
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-1.113

FOXO1-Thr478
Cancer	Intensity
BRCA
COAD
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

PTM-Disease Association:

source: PTMD

Residue	Position	State	Disease	Class	PMID
T	24	D	Head and neck squamous cell carcinoma	Phosphorylation	21281788
T	24	U	Breast cancer	Phosphorylation	36797347
T	24	U	Prostate cancer	Phosphorylation	36720852

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb