Id: acc1860
Group: 2sens
Protein: MST1
Gene Symbol: STK4
Protein Id: Q13043
Protein Name: STK4_HUMAN
PTM: methylation
Site: Lys59
Site Sequence: KETGQIVAIKQVPVESDLQEI
Disease Category: Cancer
Disease: Breast Cancer
Disease Subtype:
Disease Cellline: MDA-MB-231
Disease Info:
Drug: neuregulin
Drug Info: -
Effect: modulate
Effect Info: "ROR1 phosphorylates the Tyr1307 site of HER3 upon neuregulin stimulation, which in turn recruits the LLGL2 - MAYA - NSUN6 complex to methylate Hippo/MST1, resulting in the inactivation of MST1 and the activation of YAP target genes, and inducing osteoclast differentiation and bone metastasis."
Note:
Score: 4.0
Pubmed(PMID): 28114269
Sentence Index:
Sentence:

Sequence & Structure:

METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
Y 433 D HER2-positive breast cancer Phosphorylation 30903103
- - D Hepatocellular carcinoma Ubiquitination 34029571
T 120 U Prostate cancer Phosphorylation 22619175
T 183 U Prostate cancer Phosphorylation 22619175
- - U Pancreatic cancer Ubiquitination 30673917
- - U Prostate cancer Ubiquitination 35637955
- - U Breast cancer Ubiquitination 34970341

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: