Id: acc2021
Group: 2sens
Protein: BIM
Gene Symbol: BCL2L11
Protein Id: P55916
Protein Name: UCP3_HUMAN
PTM: phosphorylation
Site: unclear
Site Sequence:
Disease Category: Cancer
Disease: Leukemia
Disease Subtype: TALL
Disease Cellline: SUPT-1
Disease Info:
Drug: prednisolone
Drug Info: "Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties, used to treat inflammatory and immune-mediated conditions such as rheumatoid arthritis, severe allergies, and autoimmune disorders."
Effect: inhibit
Effect Info: MAPK-ERK signaling causes steroid resistance through BIM phosphorylation. Treatment with a MEK inhibitor eliminates this inactivating phosphorylation of BIM.
Note: site unclear
Score: 5.0
Pubmed(PMID): 34007050
Sentence Index:
Sentence:

Sequence & Structure:

MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALMKVQMLRESPF

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

BCL2L11-Ser104
Cancer Intensity
BRCA
COAD
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC -0.707
BCL2L11-Ser118
Cancer Intensity
BRCA
COAD
HGSC 0.707
ccRCC
GBM
HNSC -0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC
BCL2L11-Ser77
Cancer Intensity
BRCA -1.869
COAD
HGSC 1.655
ccRCC 0.169
GBM
HNSC 0.422
LUAD 0.134
LUSC -0.138
non_ccRCC 0.29
PDAC
UCEC -0.663
BCL2L11-Ser92
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC -0.707
LUAD 0.707
LUSC
non_ccRCC
PDAC
UCEC
BCL2L11-Ser93
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC -0.707
LUAD 0.707
LUSC
non_ccRCC
PDAC
UCEC
BCL2L11-Ser94
Cancer Intensity
BRCA -1.664
COAD
HGSC 1.002
ccRCC -0.246
GBM
HNSC -0.477
LUAD 0.629
LUSC -0.105
non_ccRCC 1.47
PDAC
UCEC -0.61

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: