| Id: | acc2080 |
| Group: | 2sens |
| Protein: | Src |
| Gene Symbol: | Src |
| Protein Id: | P05480 |
| Protein Name: | SRC_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr |
| Site Sequence: | |
| Disease Category: | Cancer |
| Disease: | Breast Cancer |
| Disease Subtype: | mammary adenocarcinoma |
| Disease Cellline: | TSA-E1 |
| Disease Info: | |
| Drug: | Met-F-AEA |
| Drug Info: | - |
| Effect: | modulate |
| Effect Info: | "Treatment with Met-F-AEA inhibits the invasion and metastasis of tumor cells, and the tyrosine phosphorylation of both FAK and Src decreases." |
| Note: | site unclear |
| Score: | 4.0 |
| Pubmed(PMID): | 16343481 |
| Sentence Index: | 16343481_6-7 |
| Sentence: | "In Met-F-AEA-treated cells, we observed a decreased tyrosine phosphorylation of both FAK and Src, this effect being attenuated by SR141716A. We propose that CB1 receptor agonists inhibit tumor cell invasion and metastasis by modulating FAK phosphorylation, and that CB1 receptor activation might represent a novel therapeutic strategy to slow down the growth of breast carcinoma and to inhibit its metastatic diffusion in vivo." |
Sequence & Structure:
MGSNKSKPKDASQRRRSLEPSENVHGAGGAFPASQTPSKPASADGHRGPSAAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
