PMADS

Id:	acc2093
Group:	2sens
Protein:	MMP-9
Gene Symbol:	MMP9
Protein Id:	P14780
Protein Name:	MMP9_HUMAN
PTM:	phosphorylation
Site:	unclear
Site Sequence:
Disease Category:	Cancer
Disease:	Breast Cancer
Disease Subtype:
Disease Cellline:	MCF7
Disease Info:
Drug:	SFN
Drug Info:	-
Effect:	modulate
Effect Info:	"The SFN treatment inhibits breast cancer cells, and the phosphorylation of MMP - 9 protein is suppressed."
Note:	site unclear
Score:	4.0
Pubmed(PMID):	35988280
Sentence Index:	35988280_9-10
Sentence:	"Results showed that Breast cancer cells treated with SFN showed reduced cell proliferation, decreased cell activity, increased apoptosis ratio, and inhibited gene expression and protein phosphorylation of MMP-9 as well as gene expression of NF-kappaB (P < 0.05). The same effect occurred with transfection of Si-RNA- MMP-9 and Si-RNA-NF-kappaB in breast cancer cells, while transfection of pcDNA3.1-MMP-9 plasmid significantly redeemed the inhibitory effect of SFN on breast cancer cells (P < 0.05)."

Sequence & Structure:

MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target	Drug name	MOA	Phase	Status	Disease	Source
MMP9	ANDECALIXIMAB	Matrix metalloproteinase 9 inhibitor	3	Completed	gastric adenocarcinoma	ClinicalTrials
MMP9	MARIMASTAT	Matrix metalloproteinase 9 inhibitor	3	Completed	breast cancer	ClinicalTrials
MMP9	MARIMASTAT	Matrix metalloproteinase 9 inhibitor	3	Completed	lung cancer	ClinicalTrials ClinicalTrials
MMP9	AZD-1236	Matrix metalloproteinase 9 inhibitor	2	Completed	chronic obstructive pulmonary disease	ClinicalTrials ClinicalTrials
MMP9	ANDECALIXIMAB	Matrix metalloproteinase 9 inhibitor	2	Terminated	Crohn's disease	ClinicalTrials
MMP9	REBIMASTAT	Matrix metalloproteinase 9 inhibitor	2	Completed	prostate adenocarcinoma	ClinicalTrials
MMP9	ANDECALIXIMAB	Matrix metalloproteinase 9 inhibitor	2	Terminated	rheumatoid arthritis	ClinicalTrials
MMP9	ANDECALIXIMAB	Matrix metalloproteinase 9 inhibitor	2	Terminated	ulcerative colitis	ClinicalTrials
MMP9	CTS-1027	Matrix metalloproteinase 9 inhibitor	2	Completed	hepatitis C virus infection	ClinicalTrials ClinicalTrials
MMP9	CTS-1027	Matrix metalloproteinase 9 inhibitor	2	Terminated	hepatitis C virus infection	ClinicalTrials
MMP9	CTS-1027	Matrix metalloproteinase 9 inhibitor	2	Completed	chronic hepatitis C virus infection	ClinicalTrials
MMP9	REBIMASTAT	Matrix metalloproteinase 9 inhibitor	2	Terminated	breast cancer	ClinicalTrials
MMP9	REBIMASTAT	Matrix metalloproteinase 9 inhibitor	2	Completed	lung cancer	ClinicalTrials
MMP9	ANDECALIXIMAB	Matrix metalloproteinase 9 inhibitor	2	Terminated	cystic fibrosis	ClinicalTrials
MMP9	AZD-1236	Matrix metalloproteinase 9 inhibitor	2	Withdrawn	cystic fibrosis	ClinicalTrials
MMP9	ANDECALIXIMAB	Matrix metalloproteinase 9 inhibitor	1	Completed	chronic obstructive pulmonary disease	ClinicalTrials
MMP9	ANDECALIXIMAB	Matrix metalloproteinase 9 inhibitor	1	Terminated	gastric adenocarcinoma	ClinicalTrials
MMP9	ANDECALIXIMAB	Matrix metalloproteinase 9 inhibitor	1	Completed	rheumatoid arthritis	ClinicalTrials
MMP9	REBIMASTAT	Matrix metalloproteinase 9 inhibitor	1	Completed	sarcoma	ClinicalTrials
MMP9	ANDECALIXIMAB	Matrix metalloproteinase 9 inhibitor	1	Completed	ulcerative colitis	ClinicalTrials ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets

Small molecule

Antibody

PROTAC

Other modalities

Approved Drug

Advanced Clinical

Phase 1 Clinical

Structure with Ligand

High-Quality Ligand

High-Quality Pocket

Med-Quality Pocket

Druggable Family

Approved Drug

Advanced Clinical

Phase 1 Clinical

UniProt loc high conf

GO CC high conf

UniProt loc med conf

UniProt SigP or TMHMM

GO CC med conf

Human Protein Atlas loc

Approved Drug

Advanced Clinical

Phase 1 Clinical

Literature

UniProt Ubiquitination

Database Ubiquitination

Half-life Data

Small Molecule Binder

Approved Drug

Advanced Clinical

Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb