| Id: | acc2097 |
| Group: | 2sens |
| Protein: | KNL1 |
| Gene Symbol: | KNL1 |
| Protein Id: | Q8NG31 |
| Protein Name: | KNL1_HUMAN |
| PTM: | phosphorylation |
| Site: | Thr875 |
| Site Sequence: | KEKQNVKIWGRKSVGGPKIDK |
| Disease Category: | Cancer |
| Disease: | Breast Cancer |
| Disease Subtype: | TNBC |
| Disease Cellline: | MDA-MB-231 |
| Disease Info: | |
| Drug: | paclitaxel |
| Drug Info: | "Paclitaxel is a plant-derived alkaloid and potent antineoplastic agent that stabilizes microtubules to inhibit cancer cell division, primarily used in the treatment of ovarian, breast, and lung cancers. " |
| Effect: | inhibit |
| Effect Info: | "BOS172722 reduces the phosphorylation of KNL1 by inhibiting the activity of MPS1, thereby enhancing the antitumor effect of paclitaxel." |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 31575759 |
| Sentence Index: | 31575759_3-4 |
| Sentence: | "BOS172722 synergizes with paclitaxel to induce gross chromosomal segregation defects caused by MPS1 inhibitor-mediated abrogation of the mitotic delay induced by paclitaxel treatment. In in vivo pharmacodynamic experiments, BOS172722 potently inhibits the spindle assembly checkpoint induced by paclitaxel in human tumor xenograft models of TNBC, as measured by inhibition of the phosphorylation of histone H3 and the phosphorylation of the MPS1 substrate, KNL1." |
Sequence & Structure:
MDGVSSEANEENDNIERPVRRRHSSILKPPRSPLQDLRGGNERVQESNALRNKKNSRRVSFADTIKVFQTESHMKIVRKSEMEGCSAMVPSQLQLLPPGFKRFSCLSLPETETGENLLLIQNKKLEDNYCEITGMNTLLSAPIHTQMQQKEFSIIEHTRERKHANDQTVIFSDENQMDLTSSHTVMITKGLLDNPISEKSTKIDTTSFLANLKLHTEDSRMKKEVNFSVDQNTSSENKIDFNDFIKRLKTGKCSAFPDVPDKENFEIPIYSKEPNSASSTHQMHVSLKEDENNSNITRLFREKDDGMNFTQCHTANIQTLIPTSSETNSRESKGNDITIYGNDFMDLTFNHTLQILPATGNFSEIENQTQNAMDVTTGYGTKASGNKTVFKSKQNTAFQDLSINSADKIHITRSHIMGAETHIVSQTCNQDARILAMTPESIYSNPSIQGCKTVFYSSCNDAMEMTKCLSNMREEKNLLKHDSNYAKMYCNPDAMSSLTEKTIYSGEENMDITKSHTVAIDNQIFKQDQSNVQIAAAPTPEKEMMLQNLMTTSEDGKMNVNCNSVPHVSKERIQQSLSNPLSISLTDRKTELLSGENMDLTESHTSNLGSQVPLAAYNLAPESTSESHSQSKSSSDECEEITKSRNEPFQRSDIIAKNSLTDTWNKDKDWVLKILPYLDKDSPQSADCNQEIATSHNIVYCGGVLDKQITNRNTVSWEQSLFSTTKPLFSSGQFSMKNHDTAISSHTVKSVLGQNSKLAEPLRKSLSNPTPDYCHDKMIICSEEEQNMDLTKSHTVVIGFGPSELQELGKTNLEHTTGQLTTMNRQIAVKVEKCGKSPIEKSGVLKSNCIMDVLEDESVQKPKFPKEKQNVKIWGRKSVGGPKIDKTIVFSEDDKNDMDITKSYTIEINHRPLLEKRDCHLVPLAGTSETILYTCRQDDMEITRSHTTALECKTVSPDEITTRPMDKTVVFVDNHVELEMTESHTVFIDYQEKERTDRPNFELSQRKSLGTPTVICTPTEESVFFPGNGESDRLVANDSQLTPLEEWSNNRGPVEVADNMELSKSATCKNIKDVQSPGFLNEPLSSKSQRRKSLKLKNDKTIVFSENHKNDMDITQSCMVEIDNESALEDKEDFHLAGASKTILYSCGQDDMEITRSHTTALECKTLLPNEIAIRPMDKTVLFTDNYSDLEVTDSHTVFIDCQATEKILEENPKFGIGKGKNLGVSFPKDNSCVQEIAEKQALAVGNKIVLHTEQKQQLFAATNRTTNEIIKFHSAAMDEKVIGKVVDQACTLEKAQVESCQLNNRDRRNVDFTSSHATAVCGSSDNYSCLPNVISCTDNLEGSAMLLCDKDEEKANYCPVQNDLAYANDFASEYYLESEGQPLSAPCPLLEKEEVIQTSTKGQLDCVITLHKDQDLIKDPRNLLANQTLVYSQDLGEMTKLNSKRVSFKLPKDQMKVYVDDIYVIPQPHFSTDQPPLPKKGQSSINKEEVILSKAGNKSLNIIENSSAPICENKPKILNSEEWFAAACKKELKENIQTTNYNTALDFHSNSDVTKQVIQTHVNAGEAPDPVITSNVPCFHSIKPNLNNLNGKTGEFLAFQTVHLPPLPEQLLELGNKAHNDMHIVQATEIHNINIISSNAKDSRDEENKKSHNGAETTSLPPKTVFKDKVRRCSLGIFLPRLPNKRNCSVTGIDDLEQIPADTTDINHLETQPVSSKDSGIGSVAGKLNLSPSQYINEENLPVYPDEINSSDSINIETEEKALIETYQKEISPYENKMGKTCNSQKRTWVQEEEDIHKEKKIRKNEIKFSDTTQDREIFDHHTEEDIDKSANSVLIKNLSRTPSSCSSSLDSIKADGTSLDFSTYRSSQMESQFLRDTICEESLREKLQDGRITIREFFILLQVHILIQKPRQSNLPGNFTVNTPPTPEDLMLSQYVYRPKIQIYREDCEARRQKIEELKLSASNQDKLLVDINKNLWEKMRHCSDKELKAFGIYLNKIKSCFTKMTKVFTHQGKVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQLSLSEWDVVEWSDDQAVFTFVYDTIQLTITFEESVVGFPFLDKRYRKIVDVNFQSLLDEDQAPPSSLLVHKLIFQYVEEKESWKKTCTTQHQLPKMLEEFSLVVHHCRLLGEEIEYLKRWGPNYNLMNIDINNNELRLLFSSSAAFAKFEITLFLSAYYPSVPLPSTIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQDCHFYH
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| KNL1-Ser1050 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.271 |
| COAD | |
| HGSC | -2.417 |
| ccRCC | 0.486 |
| GBM | 0.393 |
| HNSC | 0.471 |
| LUAD | -0.037 |
| LUSC | 0.167 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.666 |
| KNL1-Ser1649 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.874 |
| COAD | |
| HGSC | 1.638 |
| ccRCC | |
| GBM | 0.477 |
| HNSC | -0.348 |
| LUAD | 0.372 |
| LUSC | -1.429 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.163 |
| KNL1-Ser1747 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.883 |
| COAD | |
| HGSC | |
| ccRCC | 0.183 |
| GBM | |
| HNSC | -0.132 |
| LUAD | |
| LUSC | 0.196 |
| non_ccRCC | |
| PDAC | 0.705 |
| UCEC | 0.931 |
| KNL1-Ser1819 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.707 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | -0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| KNL1-Ser60 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.977 |
| COAD | |
| HGSC | 1.444 |
| ccRCC | 0.167 |
| GBM | 1.255 |
| HNSC | -0.016 |
| LUAD | -1.185 |
| LUSC | -1.152 |
| non_ccRCC | |
| PDAC | -0.276 |
| UCEC | 0.74 |
| KNL1-Ser739 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -0.707 |
| LUAD | |
| LUSC | 0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| KNL1-Ser930 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 1.314 |
| ccRCC | 0.46 |
| GBM | |
| HNSC | 0.447 |
| LUAD | -1.502 |
| LUSC | -0.751 |
| non_ccRCC | |
| PDAC | 0.738 |
| UCEC | -0.705 |
| KNL1-Thr1016 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.146 |
| HNSC | |
| LUAD | |
| LUSC | -1.065 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.919 |
| KNL1-Thr513 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.882 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | -0.205 |
| non_ccRCC | |
| PDAC | |
| UCEC | 1.087 |
| KNL1-Thr991 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | -1.138 |
| ccRCC | 0.74 |
| GBM | 0.397 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
