Id: acc2099
Group: 2sens
Protein: KNL1
Gene Symbol: KNL1
Protein Id: Q8NG31
Protein Name: KNL1_HUMAN
PTM: phosphorylation
Site: Thr875
Site Sequence: KEKQNVKIWGRKSVGGPKIDK
Disease Category: Cancer
Disease: Breast Cancer
Disease Subtype: TNBC
Disease Cellline: MDA-MB-231
Disease Info:
Drug: BOS172722
Drug Info: "BOS-172722: A small molecule inhibitor with potential research applications, currently referenced in scientific product listings but lacking detailed publicly available pharmacological or clinical data. "
Effect: modulate
Effect Info: "BOS172722 can effectively inhibit the spindle assembly checkpoint induced by paclitaxel in the TNBC human tumor xenograft model, specifically manifested as inhibiting the phosphorylation of histone H3 and the phosphorylation of the MPS1 substrate KNL1."
Note:
Score: 4.0
Pubmed(PMID): 31575759
Sentence Index:
Sentence:

Sequence & Structure:

MDGVSSEANEENDNIERPVRRRHSSILKPPRSPLQDLRGGNERVQESNALRNKKNSRRVSFADTIKVFQTESHMKIVRKSEMEGCSAMVPSQLQLLPPGFKRFSCLSLPETETGENLLLIQNKKLEDNYCEITGMNTLLSAPIHTQMQQKEFSIIEHTRERKHANDQTVIFSDENQMDLTSSHTVMITKGLLDNPISEKSTKIDTTSFLANLKLHTEDSRMKKEVNFSVDQNTSSENKIDFNDFIKRLKTGKCSAFPDVPDKENFEIPIYSKEPNSASSTHQMHVSLKEDENNSNITRLFREKDDGMNFTQCHTANIQTLIPTSSETNSRESKGNDITIYGNDFMDLTFNHTLQILPATGNFSEIENQTQNAMDVTTGYGTKASGNKTVFKSKQNTAFQDLSINSADKIHITRSHIMGAETHIVSQTCNQDARILAMTPESIYSNPSIQGCKTVFYSSCNDAMEMTKCLSNMREEKNLLKHDSNYAKMYCNPDAMSSLTEKTIYSGEENMDITKSHTVAIDNQIFKQDQSNVQIAAAPTPEKEMMLQNLMTTSEDGKMNVNCNSVPHVSKERIQQSLSNPLSISLTDRKTELLSGENMDLTESHTSNLGSQVPLAAYNLAPESTSESHSQSKSSSDECEEITKSRNEPFQRSDIIAKNSLTDTWNKDKDWVLKILPYLDKDSPQSADCNQEIATSHNIVYCGGVLDKQITNRNTVSWEQSLFSTTKPLFSSGQFSMKNHDTAISSHTVKSVLGQNSKLAEPLRKSLSNPTPDYCHDKMIICSEEEQNMDLTKSHTVVIGFGPSELQELGKTNLEHTTGQLTTMNRQIAVKVEKCGKSPIEKSGVLKSNCIMDVLEDESVQKPKFPKEKQNVKIWGRKSVGGPKIDKTIVFSEDDKNDMDITKSYTIEINHRPLLEKRDCHLVPLAGTSETILYTCRQDDMEITRSHTTALECKTVSPDEITTRPMDKTVVFVDNHVELEMTESHTVFIDYQEKERTDRPNFELSQRKSLGTPTVICTPTEESVFFPGNGESDRLVANDSQLTPLEEWSNNRGPVEVADNMELSKSATCKNIKDVQSPGFLNEPLSSKSQRRKSLKLKNDKTIVFSENHKNDMDITQSCMVEIDNESALEDKEDFHLAGASKTILYSCGQDDMEITRSHTTALECKTLLPNEIAIRPMDKTVLFTDNYSDLEVTDSHTVFIDCQATEKILEENPKFGIGKGKNLGVSFPKDNSCVQEIAEKQALAVGNKIVLHTEQKQQLFAATNRTTNEIIKFHSAAMDEKVIGKVVDQACTLEKAQVESCQLNNRDRRNVDFTSSHATAVCGSSDNYSCLPNVISCTDNLEGSAMLLCDKDEEKANYCPVQNDLAYANDFASEYYLESEGQPLSAPCPLLEKEEVIQTSTKGQLDCVITLHKDQDLIKDPRNLLANQTLVYSQDLGEMTKLNSKRVSFKLPKDQMKVYVDDIYVIPQPHFSTDQPPLPKKGQSSINKEEVILSKAGNKSLNIIENSSAPICENKPKILNSEEWFAAACKKELKENIQTTNYNTALDFHSNSDVTKQVIQTHVNAGEAPDPVITSNVPCFHSIKPNLNNLNGKTGEFLAFQTVHLPPLPEQLLELGNKAHNDMHIVQATEIHNINIISSNAKDSRDEENKKSHNGAETTSLPPKTVFKDKVRRCSLGIFLPRLPNKRNCSVTGIDDLEQIPADTTDINHLETQPVSSKDSGIGSVAGKLNLSPSQYINEENLPVYPDEINSSDSINIETEEKALIETYQKEISPYENKMGKTCNSQKRTWVQEEEDIHKEKKIRKNEIKFSDTTQDREIFDHHTEEDIDKSANSVLIKNLSRTPSSCSSSLDSIKADGTSLDFSTYRSSQMESQFLRDTICEESLREKLQDGRITIREFFILLQVHILIQKPRQSNLPGNFTVNTPPTPEDLMLSQYVYRPKIQIYREDCEARRQKIEELKLSASNQDKLLVDINKNLWEKMRHCSDKELKAFGIYLNKIKSCFTKMTKVFTHQGKVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQLSLSEWDVVEWSDDQAVFTFVYDTIQLTITFEESVVGFPFLDKRYRKIVDVNFQSLLDEDQAPPSSLLVHKLIFQYVEEKESWKKTCTTQHQLPKMLEEFSLVVHHCRLLGEEIEYLKRWGPNYNLMNIDINNNELRLLFSSSAAFAKFEITLFLSAYYPSVPLPSTIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQDCHFYH

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

KNL1-Ser1050
Cancer Intensity
BRCA 0.271
COAD
HGSC -2.417
ccRCC 0.486
GBM 0.393
HNSC 0.471
LUAD -0.037
LUSC 0.167
non_ccRCC
PDAC
UCEC 0.666
KNL1-Ser1649
Cancer Intensity
BRCA -0.874
COAD
HGSC 1.638
ccRCC
GBM 0.477
HNSC -0.348
LUAD 0.372
LUSC -1.429
non_ccRCC
PDAC
UCEC 0.163
KNL1-Ser1747
Cancer Intensity
BRCA -1.883
COAD
HGSC
ccRCC 0.183
GBM
HNSC -0.132
LUAD
LUSC 0.196
non_ccRCC
PDAC 0.705
UCEC 0.931
KNL1-Ser1819
Cancer Intensity
BRCA 0.707
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC -0.707
non_ccRCC
PDAC
UCEC
KNL1-Ser60
Cancer Intensity
BRCA -0.977
COAD
HGSC 1.444
ccRCC 0.167
GBM 1.255
HNSC -0.016
LUAD -1.185
LUSC -1.152
non_ccRCC
PDAC -0.276
UCEC 0.74
KNL1-Ser739
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC -0.707
LUAD
LUSC 0.707
non_ccRCC
PDAC
UCEC
KNL1-Ser930
Cancer Intensity
BRCA
COAD
HGSC 1.314
ccRCC 0.46
GBM
HNSC 0.447
LUAD -1.502
LUSC -0.751
non_ccRCC
PDAC 0.738
UCEC -0.705
KNL1-Thr1016
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM 0.146
HNSC
LUAD
LUSC -1.065
non_ccRCC
PDAC
UCEC 0.919
KNL1-Thr513
Cancer Intensity
BRCA
COAD
HGSC
ccRCC -0.882
GBM
HNSC
LUAD
LUSC -0.205
non_ccRCC
PDAC
UCEC 1.087
KNL1-Thr991
Cancer Intensity
BRCA
COAD
HGSC -1.138
ccRCC 0.74
GBM 0.397
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: