| Id: | acc2117 |
| Group: | 2sens |
| Protein: | p21WAF1/CIP2 |
| Gene Symbol: | CDKN1A |
| Protein Id: | P38936 |
| Protein Name: | CDN1A_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser146 |
| Site Sequence: | SQGRKRRQTSMTDFYHSKRRL |
| Disease Category: | Cancer |
| Disease: | Hepatocellular Carcinoma |
| Disease Subtype: | |
| Disease Cellline: | HepG2 |
| Disease Info: | |
| Drug: | asiatic acid |
| Drug Info: | "Asiatic acid is a pentacyclic triterpenoid derived from *Centella asiatica*, exhibiting anticancer activity by inducing apoptosis in melanoma cells and possessing anti-inflammatory properties through inhibition of TNF-alpha-induced endothelial barrier dysfunction and modulation of the NLRP3 inflammasome and NF-κB pathway." |
| Effect: | modulate |
| Effect Info: | Asian acid reduces p21 phosphorylation and inhibits the proliferation of HepG2 cells. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 24568526 |
| Sentence Index: | 24568526_4-5 |
| Sentence: | "Here we report that asiatic acid up-regulates p21WAF1/CIP1 protein expression but not the level of p21WAF1/CIP1 mRNA in HepG2 human hepatoma cells. Furthermore, we found that the asiatic acid induced increase of p21WAF1/CIP1 protein was associated with decreased phosphorylation (ser-146) of p21WAF1/CIP1." |
Sequence & Structure:
MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTAC| CDKN1A-Ser130 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.129 |
| COAD | |
| HGSC | |
| ccRCC | 0.266 |
| GBM | 1.728 |
| HNSC | -0.567 |
| LUAD | -0.85 |
| LUSC | -0.21 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.763 |
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| - | - | A | Pancreatic cancer/carcinoma/adenocarcinoma | Acetylation | 24301926 |
| - | - | U | Medulloblastoma | Neddylation | 29984917 |
| T | 145 | U | Prostate cancer | Phosphorylation | 34069970 |
| - | - | U | Breast cancer/tumor/carcinoma | Ubiquitination | 24027428 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
