| Id: | acc2163 |
| Group: | 2sens |
| Protein: | PAX3-FOXO1 |
| Gene Symbol: | PAX3 |
| Protein Id: | P23760 |
| Protein Name: | PAX3_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser205 |
| Site Sequence: | ASAPQSDEGSDIDSEPDLPLK |
| Disease Category: | Cancer |
| Disease: | Sarcoma |
| Disease Subtype: | alveolar rhabdomyosarcoma |
| Disease Cellline: | RH4 |
| Disease Info: | |
| Drug: | LiCl |
| Drug Info: | "Lithium chloride (LiCl) is investigated for its potential therapeutic applications, including its role in hypertension treatment through blood pressure reduction and endothelial protection, as well as its antitumor effects in experimental studies." |
| Effect: | modulate |
| Effect Info: | Inhibiting the phosphorylation of the oncogenic fusion protein PAX3 - FOXO1 at Ser201 and Ser205 sites can suppress tumors. |
| Note: | fusion protein |
| Score: | 4.0 |
| Pubmed(PMID): | 25821947 |
| Sentence Index: | 25821947_7-8 |
| Sentence: | "We found that inhibiting the phosphorylation of PAX3-FOXO1 at Ser201 significantly reduced migration, invasion and proliferation in two independent ARMS tumor cell lines. Further, we found that inhibition of phosphorylation at Ser205 also decreased proliferation and anchorage-independent growth." |
Sequence & Structure:
MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLEPTTTVSASCSQRLDHMKSLDSLPTSQSYCPPTYSTTGYSMDPVTGYQYGQYGQSKPWTF
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
