| Id: | acc2164 |
| Group: | 2sens |
| Protein: | PAX3-FOXO1 |
| Gene Symbol: | PAX3 |
| Protein Id: | P23760 |
| Protein Name: | PAX3_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser201 |
| Site Sequence: | LSERASAPQSDEGSDIDSEPD |
| Disease Category: | Cancer |
| Disease: | Sarcoma |
| Disease Subtype: | alveolar rhabdomyosarcoma |
| Disease Cellline: | Rh30 |
| Disease Info: | |
| Drug: | AR-A014418 |
| Drug Info: | "AR-A014418 is a selective glycogen synthase kinase-3beta (GSK-3beta) inhibitor with an IC50 value of 104 nM, primarily used in laboratory research to study apoptotic signaling pathways." |
| Effect: | modulate |
| Effect Info: | Inhibiting the phosphorylation of the oncogenic fusion protein PAX3 - FOXO1 at Ser201 and Ser205 can suppress tumors. |
| Note: | fusion protein |
| Score: | 4.0 |
| Pubmed(PMID): | 25821947 |
| Sentence Index: | 25821947_7-8 |
| Sentence: | "We found that inhibiting the phosphorylation of PAX3-FOXO1 at Ser201 significantly reduced migration, invasion and proliferation in two independent ARMS tumor cell lines. Further, we found that inhibition of phosphorylation at Ser205 also decreased proliferation and anchorage-independent growth." |
Sequence & Structure:
MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLEPTTTVSASCSQRLDHMKSLDSLPTSQSYCPPTYSTTGYSMDPVTGYQYGQYGQSKPWTF
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
