| Id: | acc2318 |
| Group: | 2sens |
| Protein: | CtIP |
| Gene Symbol: | RBBP8 |
| Protein Id: | Q99708 |
| Protein Name: | CTIP_HUMAN |
| PTM: | phosphorylation |
| Site: | Thr847 |
| Site Sequence: | HRFRYIPPNTPENFWEVGFPS |
| Disease Category: | Cancer |
| Disease: | Ovarian Cancer |
| Disease Subtype: | |
| Disease Cellline: | IGROV1 |
| Disease Info: | |
| Drug: | olaparib |
| Drug Info: | "Olaparib is a PARP (poly ADP-ribose polymerase) inhibitor used to treat BRCA-mutated cancers, including ovarian, breast, pancreatic, and prostate cancers, by blocking DNA repair mechanisms in tumor cells, leading to synthetic lethality. " |
| Effect: | promote |
| Effect Info: | A decrease in protein phosphorylation renders drug-resistant cells sensitive to drugs. |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 37333340 |
| Sentence Index: | 37333340_5-6 |
| Sentence: | "Once at the break site, Syk phosphorylates CtIP, a key mediator of resection and HR, at Thr-847 to promote repair activity, specifically in Syk expressing cancer cells. Syk inhibition or genetic deletion abolished CtIP Thr-847 phosphorylation and overcame the resistant phenotype." |
Sequence & Structure:
MNISGSSCGSPNSADTSSDFKDLWTKLKECHDREVQGLQVKVTKLKQERILDAQRLEEFFTKNQQLREQQKVLHETIKVLEDRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCPRPKRRQPYNAIFSPKGKEQKT
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| RBBP8-Ser163 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.129 |
| COAD | 0.416 |
| HGSC | -1.296 |
| ccRCC | 0.145 |
| GBM | |
| HNSC | -0.352 |
| LUAD | -0.128 |
| LUSC | -0.469 |
| non_ccRCC | 0.384 |
| PDAC | 1.717 |
| UCEC | -1.547 |
| RBBP8-Ser327 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.681 |
| COAD | 0.482 |
| HGSC | -1.39 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | 1.028 |
| UCEC | 0.561 |
| RBBP8-Ser347 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | -0.548 |
| ccRCC | |
| GBM | |
| HNSC | -0.606 |
| LUAD | |
| LUSC | |
| non_ccRCC | 1.154 |
| PDAC | |
| UCEC | |
| RBBP8-Ser539 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.25 |
| COAD | |
| HGSC | 2.246 |
| ccRCC | 0.249 |
| GBM | |
| HNSC | -0.822 |
| LUAD | -0.616 |
| LUSC | -0.389 |
| non_ccRCC | 0.224 |
| PDAC | 0.101 |
| UCEC | 0.255 |
| RBBP8-Ser568 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.456 |
| COAD | |
| HGSC | 2.031 |
| ccRCC | 0.491 |
| GBM | -0.064 |
| HNSC | 0.041 |
| LUAD | -1.132 |
| LUSC | -1.418 |
| non_ccRCC | |
| PDAC | 0.259 |
| UCEC | 0.248 |
| RBBP8-Ser593 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.565 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -0.171 |
| LUAD | 1.124 |
| LUSC | 0.493 |
| non_ccRCC | |
| PDAC | 0.119 |
| UCEC | |
| RBBP8-Ser723 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.737 |
| COAD | |
| HGSC | |
| ccRCC | 0.822 |
| GBM | |
| HNSC | 0.326 |
| LUAD | |
| LUSC | 0.411 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.178 |
| RBBP8-Thr245 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.779 |
| COAD | |
| HGSC | 1.128 |
| ccRCC | |
| GBM | -0.349 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| RBBP8-Thr315 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -2.209 |
| HGSC | -0.431 |
| ccRCC | |
| GBM | |
| HNSC | 0.127 |
| LUAD | 0.754 |
| LUSC | -0.212 |
| non_ccRCC | 0.639 |
| PDAC | 0.738 |
| UCEC | 0.594 |
| RBBP8-Thr323 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| RBBP8-Thr596 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| RBBP8-Tyr244 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -0.707 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.707 |
| RBBP8NL-Ser145 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.272 |
| HGSC | -1.633 |
| ccRCC | 1.108 |
| GBM | |
| HNSC | |
| LUAD | 0.137 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.116 |
| RBBP8NL-Ser151 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.409 |
| COAD | -0.481 |
| HGSC | |
| ccRCC | 1.482 |
| GBM | |
| HNSC | 1.087 |
| LUAD | -1.021 |
| LUSC | -0.523 |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.953 |
| RBBP8NL-Ser190 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| RBBP8NL-Ser196 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.731 |
| COAD | -0.589 |
| HGSC | -2.227 |
| ccRCC | 0.644 |
| GBM | |
| HNSC | 1.251 |
| LUAD | -0.311 |
| LUSC | -0.625 |
| non_ccRCC | -0.035 |
| PDAC | 0.664 |
| UCEC | 0.499 |
| RBBP8NL-Ser210 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.033 |
| COAD | 0.153 |
| HGSC | -1.836 |
| ccRCC | |
| GBM | |
| HNSC | 0.409 |
| LUAD | |
| LUSC | -0.294 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.535 |
| RBBP8NL-Ser250 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 1.147 |
| LUAD | -0.461 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.686 |
| RBBP8NL-Ser251 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.684 |
| COAD | -0.625 |
| HGSC | -1.465 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.641 |
| LUSC | 0.765 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| RBBP8NL-Ser254 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.117 |
| COAD | |
| HGSC | -1.713 |
| ccRCC | |
| GBM | |
| HNSC | 1.421 |
| LUAD | -0.033 |
| LUSC | 0.181 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.026 |
| RBBP8NL-Ser262 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.893 |
| COAD | 0.412 |
| HGSC | -1.188 |
| ccRCC | |
| GBM | |
| HNSC | -1.034 |
| LUAD | -0.461 |
| LUSC | |
| non_ccRCC | -0.144 |
| PDAC | |
| UCEC | 1.522 |
| RBBP8NL-Ser265 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| RBBP8NL-Ser283 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | 0.707 |
| UCEC | -0.707 |
| RBBP8NL-Ser372 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.707 |
| RBBP8NL-Ser392 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.123 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -0.089 |
| LUAD | |
| LUSC | -1.29 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.255 |
| RBBP8NL-Ser487 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.607 |
| COAD | -0.912 |
| HGSC | 1.359 |
| ccRCC | 0.655 |
| GBM | |
| HNSC | 0.443 |
| LUAD | -0.479 |
| LUSC | -0.455 |
| non_ccRCC | -0.876 |
| PDAC | 0.655 |
| UCEC | 1.217 |
| RBBP8NL-Ser645 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.935 |
| HGSC | -1.261 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | -0.258 |
| LUSC | |
| non_ccRCC | 0.304 |
| PDAC | 1.262 |
| UCEC | 0.887 |
| RBBP8NL-Thr242 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.013 |
| HGSC | 1.006 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.994 |
| RBBP8NL-Thr276 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | 0.707 |
| UCEC | |
| RBBP8NL-Thr638 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 1.154 |
| GBM | |
| HNSC | -0.535 |
| LUAD | -0.619 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| RBBP8NL-Thr640 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 1.248 |
| GBM | |
| HNSC | 0.29 |
| LUAD | -0.474 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.064 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
