Id: acc2339
Group: 2sens
Protein: STAT3
Gene Symbol: STAT3
Protein Id: P40763
Protein Name: STAT3_HUMAN
PTM: phosphorylation
Site: Tyr705
Site Sequence: EADPGSAAPYLKTKFICVTPT
Disease Category: Cancer
Disease: Myeloma
Disease Subtype: multiple myeloma
Disease Cellline: MM1.S
Disease Info:
Drug: lenalidomide
Drug Info: "Lenalidomide is an oral immunomodulatory agent used in the treatment of multiple myeloma and myelodysplastic syndromes, which exerts its therapeutic effects by inhibiting abnormal cell proliferation and modulating immune system activity."
Effect: inhibit
Effect Info: "LLL12 can specifically inhibit the phosphorylation of STAT3, and LLL12 enhances the activity of lenalidomide in U266 human multiple myeloma (MM) cells."
Note:
Score: 5.0
Pubmed(PMID): 21520044
Sentence Index:
Sentence:

Sequence & Structure:

MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 2 Recruiting head and neck squamous cell carcinoma ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 2 Active, not recruiting non-small cell lung carcinoma ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 2 Completed non-small cell lung carcinoma ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 1 Completed hepatocellular carcinoma ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 1 Active, not recruiting head and neck squamous cell carcinoma ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 1 Completed diffuse large B-cell lymphoma ClinicalTrials
ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 1 Active, not recruiting neoplasm ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 1 Active, not recruiting non-small cell lung carcinoma ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 1 Completed non-Hodgkins lymphoma ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 1 Active, not recruiting urinary bladder cancer ClinicalTrials
STAT3 DANVATIRSEN STAT-3 mRNA 3'UTR antisense inhibitor 1 Completed cancer ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
STAT3-Tyr705
Cancer Intensity
BRCA 0.868
COAD
HGSC
ccRCC
GBM 0.383
HNSC
LUAD -0.032
LUSC
non_ccRCC -1.398
PDAC 1.121
UCEC -0.942

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
Y 705 D Triple-negative breast cancer Phosphorylation 36017196
Y 705 D Inflammatory disease Phosphorylation 24063605
Y 705 N Bladder cancer Phosphorylation 18939995
Y 705 P Breast cancer/tumor/carcinoma Phosphorylation 23350355 ;  22374428 ;  23446809
Y 705 P Colon cancer/carcinoma Phosphorylation 22754353 ;  21840932
Y 705 U Experimental autoimmune encephalomyelitis Phosphorylation 32094172
Y 705 U Laryngeal cancer Phosphorylation 27181202
Y 705 U Lung cancer Phosphorylation 34543857
Y 705 U Malignant gliomas Phosphorylation 23740516
Y 705 U Multiple sclerosis Phosphorylation 32094172
Y 705 U Myeloma Phosphorylation 22210382
Y 705 U Neurofibromatosis Phosphorylation 23318430
Y 705 U Non-Hodgkin's lymphoma Phosphorylation 30054295
Y 705 U Prostate cancer Phosphorylation 19147545 ;  19147545
Y 705 U T-cell lymphoma Phosphorylation 35882439
Y 705 U Fibrosarcoma Phosphorylation 21575192
Y 705 U Head and neck squamous cell carcinoma Phosphorylation 21281788
Y 705 U Esophageal carcinoma Phosphorylation 33986510
Y 705 U Clear cell kidney cancer Phosphorylation 24615012
Y 705 U Acute myelogenous leukemia Phosphorylation 34525179
Y 705 U B-cell lymphoma Phosphorylation 22116549
Y 705 U Breast cancer Phosphorylation 17967179 ;  17967179 ;  18353781 ;  35927628
Y 705 U Esophageal squamous cell carcinoma Phosphorylation 23676499
Y 705 U Triple-negative breast cancer Phosphorylation 34066153 ;  35091679
Y 705 U Pancreatic cancer Phosphorylation 37548811 ;  36374556
Y 705 U Colorectal cancer Phosphorylation 36266267
Y 705 U Glioblastoma Phosphorylation 34411567 ;  20455003
Y 705 U Melanoma Phosphorylation 35184394 ;  22899991
Y 705 U Multiple myeloma Phosphorylation 34782371
Y 705 U Breast cancer/tumor/carcinoma Phosphorylation 24707243
Y 705 U Cancer Phosphorylation 23145121
Y 705 U Colon adenocarcinoma Phosphorylation 34270850
Y 705 U Hepatocellular carcinoma/hepatocarcinoma/hepatoma Phosphorylation 21311975
Y 705 U Pancreatic cancer/carcinoma/adenocarcinoma Phosphorylation 18519681
Y 705 U Prostate cancer/carcinoma/adenocarcinoma Phosphorylation 22307624 ;  19147545
Y 705 U Renal cancer/carcinoma Phosphorylation 22982675
Y 705 U Renal cell carcinoma Phosphorylation 22899991
Y 705 U Bladder cancer Phosphorylation 34326684
Y 705 U Glioblastoma multiforme Phosphorylation 35670018
Y 705 U Nasopharyngeal carcinoma Phosphorylation 33824475
Y 705 U Hepatocellular carcinoma Phosphorylation 22153071

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: