| Id: | acc2393 |
| Group: | 2sens |
| Protein: | STAT6 |
| Gene Symbol: | Stat6 |
| Protein Id: | P52633 |
| Protein Name: | STAT6_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr641 |
| Site Sequence: | EQMGKDGRGYVSTTIKMTVER |
| Disease Category: | Cancer |
| Disease: | Breast Cancer |
| Disease Subtype: | TNBC |
| Disease Cellline: | 4T1 |
| Disease Info: | |
| Drug: | emodin |
| Drug Info: | "Emodin is an anthraquinone derivative that acts as an anti-SARS-CoV agent by blocking the interaction between the SARS-CoV spike protein and angiotensin-converting enzyme 2 (ACE2), inhibits casein kinase 2 (CK2), exhibits anti-inflammatory and anticancer activities, serves as a selective 11beta-HSD1 inhibitor with IC50 values of 186 nM (human) and 86 nM (mouse), and improves metabolic disorders in diet-induced obese mice. " |
| Effect: | modulate |
| Effect Info: | Emodin significantly inhibits the lung metastasis of breast cancer by suppressing the phosphorylation of STAT6. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 25311112 |
| Sentence Index: | 25311112_9-10 |
| Sentence: | "In vitro experiments demonstrated that Emodin decreased the migration of macrophages toward tumor cell-conditioned medium (TCM) and inhibited macrophage M2 polarization induced by TCM. Mechanistically, Emodin suppressed STAT6 phosphorylation and C/EBPbeta expression, two crucial signaling events in macrophage M2 polarization, in macrophages treated with IL-4 or TCM." |
Sequence & Structure:
MSLWGLISKMSPEKLQRLYVDFPQRLRHLLADWLESQPWEFLVGSDAFCYNMASALLSATVQRLQATAGEQGKGNSILPHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFRHLPGPFHRKQEELKFTTALGRLQHRVRETRLLRESLQQGAKTGQVSLQNLIDPPVNGPGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPMVRADMVTEKQARELSLAQGPGTGVESTGEIMNNTVPLENSIPSNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFTLGPNKLLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSVEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVPPYDLGMAPDASMQLSSDMGYPPQSIHSFQSLEESMSVLPSFQEPHLQMPPNMSQITMPFDQPHPQGLLQCQSQEHAVSSPEPMLCSDVTMVEDSCLTQPVGGFPQGTWVSEDMYPPLMPPTEQDLTKLLLENQGEAGGSLGSQPLLQPSPYGQSGISLSHLDLRTNPSW
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
